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| 1 | Omentum facilitates liver regeneration显示文摘AIM:To investigate the mechanism of liver regeneration induced by fusing the omentum to a small traumatic injury created in the liver. We studied three groups of rats. In one group the rats were omentectomized; in another group the omentum was left in situ and was not activated,and in the third group the omentum was activated by polydextran particles. METHODS:We pre-activated the omentum by injecting polydextran particles and then made a small wedge wound in the rat liver to allow the omentum to fuse to the wound. We monitored the regeneration of the liver by determining the ratio of liver weight/body weight,by histological evaluation (including immune staining for cytokeratin-19,an oval cell marker),and by testing for developmental gene activation using reverse transcription polymerase chain reaction (RT-PCR). RESULTS:There was no liver regeneration in the omentectomized rats,nor was there significant regeneration when the omentum was not activated,even though in this instance the omentum had fusedwith the liver. In contrast,the liver in the rats with the activated omentum expanded to a size 50% greater than the original,and there was histologically an interlying tissue between the wounded liver and the activated omentum in which bile ducts,containing cytokeratin-19 positive oval cells,extended from the wound edge. In this interlying tissue,oval cells were abundant and appeared to proliferate to form new liver tissue. In rats pre-treated with drugs that inhibited hepatocyte growth,liver proliferation was ongoing,indicating that regeneration of the liver was the result of oval cell expansion. CONCLUSION:Activated omentum facilitates liver regeneration following injury by a mechanism that depends largely on oval cell proliferation. | Ashok K Singh Nishit Pancholi Jilpa Patel Natalia O Litbarg Krishnamurthy P Gudehithlu Perianna Sethupathi Mark Kraus George Dunea Jose AL Arruda | 2009 | World Journal of Gastroenterology2009，15，9： | 2 |
| 2 | DNA prime/canarypox boost-based immunotherapy of chronic hepatitis B virus infection in a chimpanzee显示文摘 | Pancholi P Lee DH Liu Q | 2001 | Hepatology2001，33，2： | 1 |
| 3 | DNA prime/canarypox boost- based immunotherapy of chronic hepatitis B virus infection in a chimpanzee显示文摘 | Pancholi P Lee D H Liu Q | 2001 | Hepatology2001，33，： | 1 |
| 4 | Genetic relatedness and molecular characterization of resistance determinants in multi-drug resistant Acinetobacter bau- mannii isolated in central Ohio,USA 显示文摘 | Srinivasan VB Rajamohan G Pancholi P | 2009 | Ann Clin Microbiol Antimicrob2009，8，6： | 1 |
| 5 | DNA prime/canarypox boost-based mmunotherapy of chronic hepatitis B virus infection in a chimpanzee 显示文摘 | Pancholi P Lee DH Liu Q | 2001 | Hepatology2001，33，2： | 1 |
| 6 | Rapid detection of cytomegalovirus infection in transplant patients 显示文摘 | Pancholi P Wu F Della - Latta P | 2004 | Expert Rev Mol Diagn2004，4，2： | 1 |
| 7 | Rapid detection of cytomegalovirus infection in transplant patients显示文摘 | Pancholi P Wu F Della Latta P | 2004 | Expert Rev Mol Diagn2004，4，2： | 1 |
| 8 | Genetic related- ness and molecular characterization o{ multidrug resistant Acine- tohacter baumannii isolated in central Ohio, USA 显示文摘 | Srinivasan VB Rajamohan G Pancholi P | 2009 | Ann Clin microb Anti2009，8，1： | 1 |
| 9 | Antibodies to streptococcal surface enolase react with humanα-enolase:implications in poststreptococcal sequelae显示文摘 | Fontán P A Pancholi V Nociari M M | 2000 | Journal of Infectious Diseases2000，182，6： | 1 |
| 10 | Strain-specific regulato- ry role of eukaryote-like serine / threonine phosphatase in pneumococ- cal adherence显示文摘 | Agarwal S Agarwal S Pancholi P | 2012 | Infeet Immun2012，80，4： | 1 |
| 11 | DNA prime/canarypox boost-based immuotherpapy of chronic hepatitis B virus infection in a chimpanzee显示文摘 | PANCHOLI P LEE DH LIU Q | 2001 | Hepatology2001，33，2： | 1 |
| 12 | Rapid detection of cytomegalovirus infection in transplant patients显示文摘 | Pancholi P Wu F Della Latta P | 2004 | Expert Rev Mol Diagn2004，4，2： | 1 |
| 13 | Rapid detection of cytomegalovirus infection in transplant patients 显示文摘 | Pancholi P Wu F Della-Latta P | 2004 | Expert Rev Mol Diagn2004，4，2： | 1 |
| 14 | DNA prime/canarypox boost-based immunotherapy of chronic hepatitis B virus infection in a chimpanzee显示文摘 | Pancholi P Lee DH Liu Q | 2001 | Hepatology2001，33，2： | 1 |
| 15 | Tomato MAPKs LeMPK1, LeMPK2, and LeMPK3 function in the systemin mediated defense response against herbivorous insects 显示文摘 | Kandoth P K Ranf S Pancholi S S | 2007 | Proceedings of the National Academy of Sciences of the United States of America2007，104，12： | 1 |
| 16 | Role of serine/ threonine phosphatase (SP-STP) in Streptococcus pyogenes physiology and virulence显示文摘 | AGARWAL S PANCHOLI P PANCHOLI V | 2011 | 1 Bioi Chern2011，286，41： | 1 |
| 17 | Serine/threonine phosphatase (SP-STP) , secreted from Streptococcus pyogenes, is a pro-apoptotic protein显示文摘 | AGARWAL S JIN H PANCHOLI P | 2012 | J Bioi Chern2012，287，： | 1 |
| 18 | Rapid screening of urine specimens for bacteriuria by the cellenium system显示文摘 | Pancholi P Pavletich K Della-Latta P | 2005 | J Clin Microbiol2005，43，10： | 1 |
| 19 | Genetic relatedness and molecular characterization of multidrug resistant Acinetobacter baumannii isolated in central Ohio, USA 显示文摘 | Srinivasan VB Rajamohan G Pancholi P | 2009 | Ann Clin Microbial Antimicrob2009，8，： | 1 |
| 20 | Ixodes dammini as potential vector of human granulocytic ehrlichiosis显示文摘 | Pancholi P Kolbert CR Mitchell PD | 1995 | J Infect Dis1995，172，： | 1 |
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