|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Worldwide trends in gastric cancer mortality (1980–2011), with predictions to 2015, and incidence by subtype显示文摘 | Ana Ferro Bárbara Peleteiro Matteo Malvezzi Cristina Bosetti Paola Bertuccio Fabio Levi Eva Negri Carlo La Vecchia Nuno Lunet | 2014 | European Journal of Cancer2014，，： | 3 |
| 3 | Low plateletalpha2beta1 levels in type I von Willebrand disease correlate withimpaired platelet function in a high shear stress system显示文摘 | Di Paola J Federici A B Mannucci P M | 1999 | Blood1999，93，11： | 1 |
| 4 | Urokinase plasminogen activator, uPA receptor and its inhibitor in vernal keratoconjunctivitis显示文摘 | ANDREA L PAOLA B MARIA T S | 2005 | Invest Ophthalm Vis Sci2005，46，： | 1 |
| 5 | Consitutive expression of Angiopoietin-1 and -2 and modulation of their Expression by inflammatory cytokine in rheumatoid arthritis synovial fibroblasts显示文摘 | Paola F Zaratin Antonio Colombo | 2002 | Rheumatology2002，29，： | 1 |
| 6 | Phylogenetic analysis of partial S1 and N gene sequences of infectious bronchitis virus isolates from Italy revealed genetic diversity and recombination显示文摘 | YURY A B GIOVANNI T PAOLA M | 2007 | Virus Genes2007，35，： | 1 |
| 7 | Matrix metalloproteinases (MMP9 and MMP2) induce the release of vascular endothelial growth factor (VEGF) by ovarian carcinoma cells显示文摘 | Dorins B Paola P | 2003 | Cancer Res2003，63，： | 1 |
| 8 | Chemical analysis and quality control of Gink- go biloba leaves, extracts, and phytopharmaceuticals 显示文摘 | Teris A B Paola M | 2009 | Chroma- tog A2009，1216，11： | 1 |
| 9 | Laser diffraction, transmission electron microscopy and image analysis to evaluate a bimodal Gaussian model for particle size distribution in soils显示文摘 | Linda P Macro B Paola R P | 2006 | Geoderma2006，135，： | 1 |
| 10 | Preparation, characteriza- tion and properties of sterically stabilized paclitaxe- containing liposomes 显示文摘 | PAOLA C MAURIZIO C PAOLA B | 2000 | Journal of Controlled Release2000，63，： | 1 |
| 11 | PAF produced by human breast cancer cells promotes migration and proliferation of tumor cells and neoangiogenesis显示文摘 | Benedetta B Biancone LG Paola C | 2000 | American of Pathology2000，21，11： | 1 |
| 12 | Postprandial anti-inflammatory and antioxidant effects of extra virgin olive oil 显示文摘 | Paola B Claudio G Marco V | 2007 | Atherosclerosis2007，190，： | 1 |
| 13 | Properties of a cellular braided-stream model显示文摘 | Murray A B Paola C | | 0，，： | 1 |
| 14 | Bacillus stearothermophilus disk assay for determining ampicillin residues in fish muscle显示文摘 | Plakas S M Paola A D Moxey M B | 1991 | J Assoc Off Anal Chem1991，74，6： | 1 |
| 15 | Syntheses and X-ray crystal structures of derivatives of 2,2',4,4',6,6'-hexaiodobiphenyl显示文摘 | PIER L A MARINO B PAOLA P | 2001 | J Chem Soc Perkin Trans 12001，126，10： | 1 |
| 16 | Serum enzyme moni- toring in sports medicine显示文摘 | Paola B Nicola M Rosa B | 2008 | Clinics in Sports Medicine2008，27，1： | 1 |
| 17 | It's time for chronotherapy! 显示文摘 | B Couderta C Focanb E Donato di Paola | 2002 | European Journal of Cancer2002，38，4： | 1 |
| 18 | Production of L- ascorbie acid by metabolically engineered saccharo 2 myces- cerevisiae and zygosaccharomyces bailii 显示文摘 | Michanl Saner Paola B randuardi Minoska Valli | 2004 | Applied and Environ-mental Microbiology2004，70，10： | 1 |
| 19 | Geomorphology and sequence stratigraphy due to slow and rapid base-level changes in an experimental subsiding basin显示文摘 | Heller P L Paola C John B | 2001 | AAPG Bulletin2001，85，5： | 1 |
| 20 | It's time for chronotherapy!显示文摘 | Coudert B Focan C Donato di Paola E | | 0，，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员