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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Acquired TRAIL resistant in human breast cancer cells are caused by the sustained cFLIP and XIPA protein levels and ERK activation显示文摘 | Lee TJ Lee JT Park JW | 2006 | Biochem Biophys Res Commun2006，351，4： | 1 |
| 3 | Different prognostic value of white blood cell subtypes in patients with acute cerebral infarction 显示文摘 | Kim J Song TJ Park JH | 2012 | Atherosclerosis2012，222，2： | 1 |
| 4 | TIS21 negatively regulates hepatocarcinogenesis by disruption of cyclin B1-Forkhead box M1 regulation loop显示文摘 | Park TJ Kim JY Oh SP | | 0，，05： | 1 |
| 5 | Metabolic acidosis and fatal myocardial failure after Propofol infusion in children :five case reports 显示文摘 | Parke TJ Stevens JE Rice AS | 1992 | British Med J1992，305，6854： | 1 |
| 6 | Micropatterns of spores displaying heterologous proteins显示文摘 | Park TJ Lee KB Lee SJ | 2004 | J Am Chem2004，126，10： | 1 |
| 7 | Lack of association between AQP4 polymorphisms and risk of inflammatory demyelinating disease in a Korean population显示文摘 | Park TJ Kim JH Kim H J | 2014 | Gene2014，536，： | 1 |
| 8 | Magnesium metabolism显示文摘 | Seo JW Park TJ | 2008 | Electrolyte Blood Press2008，6，2： | 1 |
| 9 | Acquired TRAIL resistance in human breast cancer cells are caused by the sustained cFLIP(L) and XIAP protein levels and ERK activation 显示文摘 | Lee TJ Lee JT Park JW | 2006 | Biochem Biophys Res Commun2006，351，4： | 1 |
| 10 | A DNA-binding factor,ArfA,interacts with the bldH promoter and affects undecylprodigiosin production in Streptomyces lividans显示文摘 | Xu D Kim TJ Park ZY | 2009 | Biochem Biophys Res Commun2009，379，2： | 1 |
| 11 | Seismic damage analysis of reinforced concrete building 显示文摘 | PARK TJ ANG A H S WEN Y K | 1985 | Journal of Structural Engineering1985，11，4： | 1 |
| 12 | Methylation of O^6 - methylgua- nine - DNA methyltransferase gene is associated significantly with Kras mutation, lymph node invasion, tumor staging , and disease free survival in patients with gastric carcinoma显示文摘 | Park TJ Han SU Cho YK | 2001 | Cancer2001，92，11： | 1 |
| 13 | Adult naked mole-rat brain retains the NMDA receptor subunit GluN2D associated with hypoxia tolerance in neonatal mammals显示文摘 | Peterson BL Park TJ LarsonJ | 2012 | Neurosci Lett2012，506，2： | 1 |
| 14 | Graphene enhances the cardiomyogenic differentiation of human embryonic stem ceils 显示文摘 | Lee TJ Park S Bhang SH | 2014 | Biochem Biophys Res Commun2014，452，1： | 1 |
| 15 | Mechanistic seismic damage model of reinforced concrete显示文摘 | PARK TJ ANG A H S WEN Y K | 1985 | Journal of Structural Engineering1985，11，4： | 1 |
| 16 | Fabrication of nano-scale liposomes containing doxorubicin using Shirasu porous glass membrane 显示文摘 | Hwang T Park TJ Koh WG | 2011 | Colloids Surf A2011，392，1： | 1 |
| 17 | Hemin,heme oxygenase-1inducer,attenuates immobilization-induced skeletal muscle atrophy in mice显示文摘 | Park CH Ju TJ Kim YW | 2013 | Life Sci2013，92，12： | 1 |
| 18 | Hormonal therapy for women with stage ia endometrial cancer of all grades显示文摘 | Park JY Kim DY Kim TJ | 2013 | Obstetrics and Gynecology2013，122，1： | 1 |
| 19 | Yield of EUS-guided FNA on the diagnosis of pancreaticiperipancreatic tuberculosis显示文摘 | Song TJ Lee SS Park do H | 2009 | Gastrointest Endose2009，69，48： | 1 |
| 20 | Clinical manifestations of salmonetfosis in children during the last 12 years: a single institution experience显示文摘 | Park JH Lee TJ | 2013 | Korean J Pediatr Infect Dis2013，20，1： | 1 |
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