|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 2 | 固定低剂量三联抗高血压药物与常规治疗对斯里兰卡轻度至中度高血压患者血压控制的疗效差异:一项随机临床试验显示文摘控制不良的高血压是全球领先的公共卫生问题,需要新的治疗策略。该研究评估低剂量三联抗高血压药物治疗是否能达到比常规治疗更好的血压控制。研究者纳入2016年2月至2017年5月在斯里兰卡11所城市医院诊所就诊的需要开始抗高血压治疗(未治疗的患者)或接受单药治疗的患者,进行低剂量三联降压与常规治疗比较的随机、开放性试验,随访至2017年10月。 | Web-ster R Salam A de Silva HA Selak V Stepien S Rajapakse S Amarasekara S Amarasena N Billot L de Silva AP Fernando M Guggilla R Jan S Jayawardena J Maulik PK Mendis S Munasinghe J Naik N Prabhakaran D Ranasinghe G Thom S Tisserra N Senaratne V Wijekoon S Wijeyasingam S Rodgers A Patel A 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 7 |
| 3 | Combination of the superior and inferior pedicle'continuities'for anastomosis of an SIEA flap to a contralateral DIEP flap in double-pedicled abdominal free flaps:a further modification of the Hamdi classification显示文摘 | Mohan A T Patel N G Malata C M | 2014 | J Plast Reconstr Aesthet Surg2014，67，10： | 1 |
| 4 | Hepatic triglyceride content and its relation to body adiposity: a magnetic resonance imaging and proton magnetic resonance spectroscopy study 显示文摘 | Thomas EL Hamilton G Patel N | 2005 | Gut2005，54，1： | 1 |
| 5 | Intra-islet endothelial cell and β-cell crosstalk: Implication for islet cell transplantation显示文摘The intra-islet microvasculature is a critical interface between the blood and islet endocrine cells governing a number of cellular and pathophysiological processes associated with the pancreatic tissue. A growing body of evidence indicates a strong functional and physical interdependency of β-cells with endothelial cells(ECs), the building blocks of islet microvasculature. Intra-islet ECs, actively regulate vascular permeability and appear to play a role in fine-tuning blood glucose sensing and regulation. These cells also tend to behave as 'guardians', controlling the expression and movement of a number of important immune mediators, thereby strongly contributing to the physiology of islets. This review will focus on the molecular signalling and crosstalk between the intra-islet ECs and β-cells and how their relationship can be a potential target for intervention strategies in islet pathology and islet transplantation. | Siddharth Narayanan Gopalakrishnan Loganathan Maheswaran Dhanasekaran William Tucker Ankit Patel Venugopal Subhashree SriPrakash Mokshagundam Michael G Hughes Stuart K Williams Appakalai N Balamurugan | 2017 | World Journal of Transplantation2017，7，2： | 1 |
| 6 | Neonatal survival of prenatally diagnosed exomphalos 显示文摘 | Patel G Sadiq J Shenker N | 2009 | Pediatr Surg Int2009，25，5： | 1 |
| 7 | Nanoparticle-Assem- bled Co-B Thin Film for the Hydrolysis of Ammonia Borane : A Highly Active Catalyst for Hydrogen Production 显示文摘 | Patel N Fernandes R Guella G | 2010 | Appl Catal B2010，95，12： | 1 |
| 8 | Stereoseleetive reduction of fl-keto esters by Geotrichum candidum 显示文摘 | Patel R N Banerjee A Mcnamee C G | 1992 | Enzyme Microb Technol1992，14，9： | 1 |
| 9 | TopologyOptimization Using a Hybrid Cellular AutomatonMethod with Local Control Rules显示文摘 | Tovar A Patel N M Niebur G L | 2006 | Journal ofMechanical Design2006，128，11： | 1 |
| 10 | Nanoparticle-assembled Co-B thin film for the hydrolysis of ammonia borane:A highly active catalyst for hydrogen production显示文摘 | Patel N Fernandes R Guella G | 2010 | Applied Catalysis B:Environmental2010，95，12： | 1 |
| 11 | Endothelial cell infection and thrombosis in paralysis caused by equid herpesvirus-l:equine stroke 显示文摘 | Bridges C G Patel J R | 1996 | Archives of Virology1996，90，： | 1 |
| 12 | Structured and Nano- particle Assembled Co-B Thin Films Prepared by Pulsed Laser Deposition: A Very Efficient Catalyst for Hydrogen Production 显示文摘 | Patel N Fernandes R Guella G | 2008 | JPhys Chem C2008，，17： | 1 |
| 13 | Hepatic triglyceride content and its relation to body adiposity: a magnetic resonance imaging and proton magnetic resonance spectroscopy study 显示文摘 | Thomas EL Hamilton G Patel N | 2005 | Gut2005，54，1： | 1 |
| 14 | Bacterial phylogeny structures soil resistomes across habitats 显示文摘 | Forsberg KJ Patel S Gibson MK Lauber CL Knight R Fierer N Dantas G | 2014 | Nature2014，59，： | 1 |
| 15 | Preparation of chiral synthon for HIV protease inhibitor: stereoselective microbial reduction of N-protected a-aminochloroketone 显示文摘 | Patel R N Banerjee A Mcnamee C G | 1997 | Tetrahedron : Asymmetry1997，8，15： | 1 |
| 16 | Topology Op- timization Using a Hybrid Cellular Automaton Method with Local Control Rules显示文摘 | Tovar A Patel N M Niebur G L | 2006 | Journal of Mechanical De- sign2006，128，6： | 1 |
| 17 | Safety and efficacy of continuous femoral nerve catheter with single shot sciatic nerve block vs epidural catheter anesthesia for same-day bilateral total knee arthroplasty显示文摘 | Patel N Solovyova O Matthews G | 2015 | J Arthroplasty2015，30，2： | 1 |
| 18 | 1H MR spectroscopy in the evaluation of the severity of chronic liver disease显示文摘 | Lim AK Hamilton G Patel N | 2003 | Radiology2003，226，： | 1 |
| 19 | Comparison between serum levels of carcinoembryonic antigen, sialic acid and phosphohexose isomerase in lung cancer 显示文摘 | Patel P S Raval G N Rawal R M | 1995 | Neoplasma1995，42，5： | 1 |
| 20 | Prognos-tic significance of immunohisto - chemically localized biomarkers instage II and stage H breast cancer, a multivariate analysis 显示文摘 | BHATAVDEKAR J M PATEL D D SHAH N G | 2000 | Ann Surg Oncol2000，7，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员