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| 1 | 热应激和低营养摄入对猪肠道完整性和功能的影响显示文摘热应激会损害肠道完整性,并诱发肠渗漏。因此,本试验研究了直接或间接热应激(通过减少采食量)对生长猪肠道通透性的影响。选用体重(43±4)kg的杂交后备母猪(n=48),分别安置在以下控制环境中:热中性(TN)环境(20℃,湿度35%~50%,自由采食)、热应激(HS)环境(35℃,湿度20%~35%,自由采食)、热中性环境配对饲喂(PFTN,以消除不同采食量的交互影响)。第1、3、7天使猪只安乐死,采集的空肠样品被安装到尤式灌流室,测定跨膜电阻抗值(TER)和异硫氰基荧光标记的脂多糖(LPS)渗透性(APP,表示为表观渗透系数)。此外,评估肠道完整性以及应激基因和蛋白标志物。结果表明,不考虑热应激天数,HS组与TN组猪相比,血浆内毒素水平增加45%(P〈0.05),空肠TER降低30%(P〈0.05),LPS渗透率增加2倍(P〈0.01)。此外,与PFTN组相比,HS组第7天的猪LPS渗透性有增加的趋势(P=0.06)。整个试验阶段HS组溶菌酶和碱性磷酸酶活性下降,分别下降46%和59%(P〈0.05);然而,3 d和7 d空肠免疫细胞标记物——髓过氧化物酶活性增加(P〈0.05)。由此可见,热应激和减少采食量都会降低肠道完整性,并增加内毒素渗透性。推测这可能会导致炎症加重,在炎热的夏季可能是导致猪生长性能降低的原因。 | Pearce S C Mani V Weber T E Rhoads R P Patience J F Baumgard L H Gabler N K | 2016 | 中国饲料2016，，3： | 3 |
| 2 | Phytochemical analysis,hepatoprotective and antioxidant activity of Alchornea cordifolia methanol leaf extract on carbon tetrachloride-induced hepatic damage in rats显示文摘Objective:To investigate the hepatoprotective and antioxidant activities of Alchornea cordifolia (A.cordifolia) leaf extract.Methods:Various solvent fractions of the methanol extract of the leaf of the plant.4.cordifolia Mull.Arg(Fam:Euphorbiaceae) were evaluated for hepatoprotective activity by carbon tetrachloride-induced liver damage in rats.The degree of protection was measured by using biochemical parameters such as serum glutamate oxalate transaminase(SGOT/ AST),serum glutamate pyruvate transaminase(SCPT/ALT),alkaline phosphatase(ALP) and total bilirubin.The in vitro antioxidant activity of the extract was also evaluated by the I,I-diphenyl 2-picrylhydrazyl(DPPH) free radical scavenging assay.The extract was subjected to preliminary phytoehemical screening.Results:The ethyl acetate and chloroform fractions,at a dose of 300 mg/kg,produced significant(P<0.05) hepatoprolection by decreasing the activities of the serum enzymes and bilirubin while there were marked scavenging of the DPPH free radicals by the fractions.The effects were comparable to those of the standard drugs used for the respective experiments,silymarin and ascorbic acid.Alkaloids,flavonoids,saponins and tannins were delected in the phylochemical screening.Conclusion:From this study,it was concluded that the plant of A.cordifolia possesses hepatoprotective as well as antioxidant activities and these activities reside mainly in the ethyl acetate and acetone fractions of methanol leaf extract. | Patience O Osadebe Festus BC Okoye Philip F Uzor Nneka R Nnamani Ijeoma E Adiele Nkemakonam C Obiano | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，4： | 2 |
| 3 | Infection of human cells by an endogenous retrovirus of pigs显示文摘 | Patience C Takeuchi Y Weiss R A | 1997 | Nat Med1997，3，3： | 1 |
| 4 | Infection of human cells by an endogenous retrovirus of pigs显示文摘 | Patience C Takeuchi Y Weiss RA | 1997 | Nat Med1997，3，： | 1 |
| 5 | Gene therapy-its potential in surgery显示文摘 | Gojo S Yamamoto S Patience C | 2002 | Ann R Coil Surg Engl2002，84，5： | 1 |
| 6 | Host range and interference studies of three classes of pig endogenous retrovirus 显示文摘 | Takeuchi Y Patience C Magre S | 1998 | J Virol1998，72，： | 1 |
| 7 | Infection of human cells by an endogenous retrovirus of pigs显示文摘 | Patience C Takeuchi Y Weiss R A | 1997 | Nat Med1997，3，： | 1 |
| 8 | Infection of human cells by an endogenous retrovirus of pigs显示文摘 | Patience C Takeuchi Y Weiss R A | 1997 | Nature Med1997，3，3： | 1 |
| 9 | Sequence analysis of the genome of poreine lymphotropie herpesvirus 1 and gene expression during posttransplant lymphoprolifemtive disease of pigs B 显示文摘 | GOLTZ M ERICSSON T PATIENCE C | 2002 | Virology2002，294，： | 1 |
| 10 | Host range and interference studies of three classes of pig endogenous retrovirus显示文摘 | Takeuchi Y Patience C Magre S | 1998 | J Virol1998，72，99： | 1 |
| 11 | Host range end interference studies of three classes of pig endogenous retrovius显示文摘 | Takeuchi Y Patience C Magre S | 1998 | Virol1998，72，12： | 1 |
| 12 | Host range and inter?ference studies of three classes of pig endogenous retrovirus显示文摘 | Takeuchi Y Patience C Magre S | 1998 | J Virol1998，72，12： | 1 |
| 13 | Pig endogenous retroviruses and xenotransplantation显示文摘 | Blusch J H Patience C Martin U | 2002 | Xenotransplantation2002，9，4： | 1 |
| 14 | Evaluation of the microbial community, acidity and proximate composition of akamu , a fermented maize food显示文摘 | Patience C Obinna‐Echem Victor Kuri Jane Beal | 2014 | Food Agric2014，，2： | 1 |
| 15 | Infection of human cells by an endogenous retrovirus of pigs显示文摘 | Patience C Takeuchi Y Weiss R A | 1997 | Nat Med1997，3，3： | 1 |
| 16 | Infection of human cells by an endogenous retrovirus of pigs 显示文摘 | Patience C Takeuchi Y Weiss RA | 1997 | Nature Med1997，，3： | 1 |
| 17 | Infection of human cells by an endogenous retrovirus of pigs显示文摘 | Patience C Takeuchi Y & Weiss R | 1997 | Nature Med1997，，3： | 1 |
| 18 | Infection of human cells by an endogenous retrovirus of pigs显示文摘 | Takeuchi Y Weiss R A | 1997 | Nat Med1997，3，3： | 1 |
| 19 | Two sets of human-tropic pig retrovirus显示文摘 | Le Tissier P Stoye J P Takeuchi Y Patience C Weiss RA | 1997 | Nature1997，389，： | 1 |
| 20 | Infection of human cells by an endogenous retrovirus of pigs显示文摘 | Takeuchi Y Weiss R A | 1997 | Nat Med1997，3，3： | 1 |
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