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| 1 | 诊断性试验和策略的证据质量和推荐强度的分级显示文摘GRADE系统能对诊断性试验或策略的证据质量和推荐强度进行分级。本文旨在阐释在此过程中如何考虑患者的重要结局, | Holger J Schünemann Andrew D Oxman Jan Brozek Paul Glasziou Roman Jaeschke Gunn E Vist John W Williams Jr Regina Kunz Jonathan Craig Victor M Montori Patrick Bossuyt Gordon H Guyatt 李晓 黄程 陈耀龙 李幼平 | 2009 | 中国循证医学杂志2009，9，5： | 7 |
| 2 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 3 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 4 | Fiber grating sensors显示文摘 | Kersey A D Davis M A Patrick H J | | 0，，： | 2 |
| 5 | Experimental Validation of a New Ultrasound Method for the Simultaneous Assessment of Radial and Longitudinal Myocardial Deformation Independent of Insonation Angle显示文摘 | Stian Langeland Jan D’hooge Patrick F. Wouters H Alex Leather Piet Claus Bart Bijnens George R. Sutherland | 2005 | Circulation2005，，14： | 2 |
| 6 | Fiber grating sensor显示文摘 | Kersey A D Davis M A Patrick H j | 1997 | Lightwave Technol1997，15，8： | 1 |
| 7 | Nitrogen and phosphorus distribution and utilization by Spartina alterniflora in a Louisiana gulf coastal marsh显示文摘 | BURESH R J DELAUNE R D PATRICK W H | 1980 | Estuaries and coasts1980，3，2： | 1 |
| 8 | Biotechnological prospects from metagenomics 显示文摘 | Patrick D SchlossJ H | 2003 | Current Opinion in Biotechnology2003，14，： | 1 |
| 9 | Sedimentation rates determined by ^137Cs dating in a rapidly accreting salt marsh显示文摘 | Delaune R D Patrick W H Bursch R J | 1978 | Nature1978，275，： | 1 |
| 10 | A multilevel automatic thresholding method based on a genetic algorithm for a fast image segmentation 显示文摘 | Kamal H Moussa D Patrick S | 2008 | Comp Vision Image Un- derstand2008，109，2： | 1 |
| 11 | Nitrous oxide emission from Gulf Coast wetlands 显示文摘 | Smith C J DeLaune R D Patrick W H Jr | 1983 | Geochimica et Cosmochimica Acta1983，47，10： | 1 |
| 12 | Davidon: RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse mode显示文摘 | Scott Q H Patrick D S He X | 2005 | PNAS2005，，16： | 1 |
| 13 | Hybrid fiber Bragg grating/long period fiber grating sensor for strain/temperature discrimination显示文摘 | Patrick H J Williams G M Kersey A D | 1996 | IEEE Photon Technol Lett1996，8，： | 1 |
| 14 | Dynamics of sediment discharge in relation to land use and hydro-climatol- ogy in a humid tropical watershed in costa rica 显示文摘 | JAGDISH K PATRICK N H DANIEL D R | 2001 | Journal of Hydrology2001，253，14： | 1 |
| 15 | Fibre Grating Sensors显示文摘 | A|an D K Davis M A Patrick H J | 1997 | Journal of Lightwave Technology1997，15，8： | 1 |
| 16 | Chernobyl Cs-137 used to determine sediment accretion rates at selected north European coastal wetlands显示文摘 | Callaway J C Delaune R D Patrick W H | 1996 | Limnology and Oceanography1996，41，3： | 1 |
| 17 | PCB and PAH releases from power stations and waste incineration processes in the UK 显示文摘 | PATRICK H D FOAN C FIEDLER H | 2003 | Chemosphere2003，50，4： | 1 |
| 18 | Lack of Association Between the MEF2A Gene and Myocardial Infarction显示文摘 | Wolfgang Lieb Bj?rn Mayer Inke R. K?nig Iris Borwitzky Anika G?tz Silke Kain Christian Hengstenberg Patrick Linsel-Nitschke Marcus Fischer Angela D?ring H -Erich Wichmann Thomas Meitinger Reinhold Kreutz Andreas Ziegler Heribert Schunkert Jeanette Erdmann | 2008 | Circulation2008，，2： | 1 |
| 19 | Fiber grating sensors显示文摘 | KERSEY A D DAVIS M A PATRICK H J | 1997 | Journal of Lightwave Technology1997，15，8： | 1 |
| 20 | Fiber grating sensors显示文摘 | KERSEY A D DAVIS M A PATRICK H J | 1997 | Lightwave Technology1997，15，8： | 1 |
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