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| 1 | Gastroesophageal reflux disease:From pathophysiology to treatment显示文摘This review focuses on the pathophysiology of gastroesophageal reflux disease (GERD) and its implications for treatment. The role of the natural anti-reflux mechanism (lower esophageal sphincter, esophageal peristalsis, diaphragm, and trans-diaphragmatic pressure gradient), mucosal damage, type of refluxate, presence and size of hiatal hernia, Helicobacter pylori infection, and Barrett’s esophagus are reviewed. The conclusions drawn from this review are: (1) the pathophysiology of GERD is multifactorial; (2) because of the pathophysiology of the disease, surgical therapy for GERD is the most appropriate treatment; and (3) the genesis of esophageal adenocarcinoma is associated with GERD. | Fernando A Herbella Marco G Patti | 2010 | World Journal of Gastroenterology2010，16，30： | 18 |
| 2 | Minimally invasive esophagectomy显示文摘Esophageal resection is associated with a high morbidity and mortality rate. Minimally invasive esophagectomy (MIE) might theoretically decrease this rate. We reviewed the current literature on MIE, with a focus on the available techniques, outcomes and comparison with open surgery. This review shows that the available literature on MIE is still crowded with heterogeneous studies with different techniques. There are no controlled and randomized trials, and the few retrospective comparative cohort studies are limited by small numbers of patients and biased by historical controls of open surgery. Based on the available literature, there is no evidence that MIE brings clear benef its compared to conventional esophagectomy. Increasing experience and the report of larger series might change this scenario. | Fernando A Herbella Marco G Patti | 2010 | World Journal of Gastroenterology2010，16，30： | 11 |
| 3 | Multidisciplinary approach for patients with esophageal cancer显示文摘Patients with esophageal cancer have a poor prognosis because they often have no symptoms until their disease is advanced. There are no screening recommendations for patients unless they have Barrett's esophagitis or a significant family history of this disease. Often, esophageal cancer is not diagnosed until patients present with dysphagia, odynophagia, anemia or weight loss. When symptoms occur, the stage is often stage Ⅲ or greater. Treatment of patients with very early stage disease is fairly straight forward using only local treatment with surgical resection or endoscopic mucosal resection. The treatment of patients who have locally advanced esophageal cancer is more complex and controversial. Despite multiple trials, treatment recommendations are still unclear due to conflicting data. Sadly, much of our data is difficult to interpret due to many of the trials done have included very heterogeneous groups of patients both histologically as well as anatomically. Additionally, studies have been underpowered or stopped early due to poor accrual. In the United States, concurrent chemoradiotherapy prior to surgical resection has been accepted by many as standard of care in the locally advanced patient. Patients who have metastatic disease are treated palliatively. The aim of this article is to describe the multidisciplinary approach used by an established team at a single high volume center for esophageal cancer, and to review the literature which guides our treatment recommendations. | Victoria M Villaflor Marco E Allaix Bruce Minsky Fernando A Herbella Marco G Patti | 2012 | World Journal of Gastroenterology2012，18，46： | 9 |
| 4 | Impact of minimally invasive surgery on the treatment of benign esophageal disorders显示文摘Thanks to the development of minimally invasive surgery, the last 20 years have witnessed a change in the treatment algorithm of benign esophageal disorders. Today a laparoscopic operation is the treatment of choice for esophageal achalasia and for most patients with gastroesophageal reflux disease. Because the pathogenesis of achalasia is unknown, treatment is palliative and aims to improve esophageal emptying by decreasing the functional obstruction at the level of the gastro-esophageal junction. The refinement of minimally invasive techniques accompanied by large, multiple randomized control trials with long-term outcome has allowed the laparoscopic Heller myotomy and partial fundoplication to become the treatment of choice for achalasia compared to endoscopic procedures, including endoscopic botulinum toxin injection and pneumatic dilatation. Patients with suspected gastroesophageal reflux need to undergo a thorough preoperative workup. After establishing diagnosis, treatment for gastroesophageal reflux should be individualized to patient characteristics and a decision about an operation made jointly between surgeon and patient. The indications for surgery have changed in the last twenty years. In the past, surgery was often considered for patients who did not respond well to acid reducing medications. Today, the best candidate for surgery is the patient who has excellent control of symptoms with proton pump inhibitors. The minimally invasive approach to antireflux surgery has allowed surgeons to control reflux in a safe manner, with excellent long term outcomes. Like achalasia and gastroesophageal reflux, the treatment of patients with paraesophageal hernias has also seen a major evolution. The laparoscopic approach has been shown to be safe, and durable, with good relief of symptoms over the long-term. The most significant controversy with laparoscopic paraesophageal hernia repair is the optimal crural repair. This manuscript reviews the evolution of these techniques. | Brian Bello Fernando A Herbella Marco E Allaix Marco G Patti | 2012 | World Journal of Gastroenterology2012，18，46： | 6 |
| 5 | Gastroesophageal reflux disease and morbid obesity: To sleeve or not to sleeve?显示文摘Laparoscopic sleeve gastrectomy(LSG) has reached wide popularity during the last 15 years, due to the limited morbidity and mortality rates, and the very good weight loss results and effects on comorbid conditions. However, there are concerns regarding the effects of LSG on gastroesophageal reflux disease(GERD). The interpretation of the current evidence is challenged by the fact that the LSG technique is not standardized, and most studies investigate the presence of GERD by assessing symptoms and the use of acid reducing medications only. A few studies objectively investigated gastroesophageal function and the reflux profile by esophageal manometry and 24-h p H monitoring, reporting postoperative normalization of esophageal acid exposure in up to 85% of patients with preoperative GERD, and occurrence of de novo GERD in about 5% of cases. There is increasing evidence showing the key role of the surgical technique on the incidence of postoperative GERD. Main technical issues are a relative narrowing of the mid portion of the gastric sleeve, a redundant upper part of the sleeve(both depending on the angle under which the sleeve is stapled), and the presence of a hiatal hernia. Concomitant hiatal hernia repair is recommended. To date, either medical therapy with proton pump inhibitors or conversion of LSG to laparoscopic Rouxen-Y gastric bypass are the available options for the management of GERD after LSG. Recently, new minimally invasive approaches have been proposed in patients with GERD and hypotensive LES: the LINX? Reflux Management System procedure and the Stretta? procedure. Large studies are needed to assess the safety and long-term efficacy of these new approaches. In conclusion, the recent publication of p H monitoring data and the new insights in the association between sleeve morphology and GERD control have led to a wider acceptance of LSG as bariatric procedure also in obese patients with GERD, as recently stated in the 5^(th) International Consensus Conference on sleeve gastrectomy. | Fabrizio Rebecchi Marco E Allaix Marco G Patti Francisco Schlottmann Mario Morino | 2017 | World Journal of Gastroenterology2017，23，13： | 4 |
| 6 | Circadian distribution of ischemic attacks and ischemia-related ventricular arrhythemias in patients with variant angina显示文摘 | Lanza GA Patti G Pasceri V | 1999 | Cardiologia1999，40，10： | 2 |
| 7 | Clopidogrel reloading in patients undergoing percutaneous coronary intervention on chronic clopidogrel therapy:results of the ARMYDA-4 RELOAD (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty) randomized trial显示文摘 | Di Sciascio G Patti G Pasceri V | | European Heart Journal0，，： | 2 |
| 8 | Percutaneous coronary intervention utilizing a new endothelial progenitor cells antibody-coated stent: a prospective singlecenter registry in high-risk patients显示文摘 | MIGLIONICO M PATTI G D'AMBROSIO A | 2008 | Catheter Cardiovasc Interv2008，71，5： | 1 |
| 9 | Atorvastatin pretreatment improves outcomes in patients with acute coronary syndromes undergoing early percutaneous coronary intervention: results of the AR- MYDA-ACS randomized trial显示文摘 | PATTI G PASCERI V COLONNA G | 2007 | J Am Coll Cardiol2007，49，： | 1 |
| 10 | Gallstone pancreatitis 显示文摘 | Patti M G Pellcgrini C A | 1990 | Stag Clin North Am1990，70，6： | 1 |
| 11 | Short-term,high-dose Atorvastatin pretreatment to prevent contrast-induced nephropathy in patients with acute coronary syndromes undergoing percutaneous coronary intervention (from the ARMYDA-CIN trial显示文摘 | Patti G Ricottini E Nusca A | 2011 | Am J Cardiol2011，108，1： | 1 |
| 12 | Prevention of complications after percu- taneous coronary interventions with statins 显示文摘 | Mega S Nusca A Patti G | 2012 | Recenti Prog Med2012，103，1： | 1 |
| 13 | Atorvastain pretreatmentimproves in patients with acute coronary synchomes nndergo-ing early percutaneous coronary intervention:results of theARMYDA-ACS randomized trial显示文摘 | Patti G Pasceri V Golonna G | 2007 | Am Coll Cardiol2007，49，12： | 1 |
| 14 | Effects of atorvas- tatin on systemic inflammatory response after coronary by-pass surgery显示文摘 | Chello M Patti G Candura D | 2006 | Crit Care Med2006，34，3： | 1 |
| 15 | Early and long- term results of stenting of diffuse coronary artery disease 显示文摘 | Di Sciascio G Patti G Nasso G | 2000 | Am J Cardiol2000，86，11： | 1 |
| 16 | Platelet function and inhibition in ischemic heart disease显示文摘 | Nusca A Patti G | | 0，，4： | 1 |
| 17 | Risk factors for postoperative delirium after colorectal surgery for carcinoma显示文摘 | Patti R Saitta M Cusumano G | 2011 | Eur J Oncol Nurs2011，15，5： | 1 |
| 18 | Point-of-care measurement of clopidogrel responsiveness predicts clinical outcome in patients undergoing percutaneous coronary intervention results of the ARMYDA-PRO (Antiplatelet Therapy for Reduction of Myocardial Damage During Angioplasty-Platelet Reactivity Predicts Outcome) study显示文摘 | Patti G Nusca A Mangiacapra F | 2008 | J Am Coll Cardiol2008，52，14： | 1 |
| 19 | Bank Competition and Firm Creation 显示文摘 | Bonaccorsi Di Patti E Dell Aricca G | 2004 | Journal of Money Credit and Banking2004，36，： | 1 |
| 20 | Randomized trial of high loadingdose of clopidogrel for reduction of periproccdural myocardial infarction in patients undergoing coronary intervention: results from the ARMYDA-2 (attiplatelet therapy for reduction of myocardial damage during angioplasty ) study 显示文摘 | Patti G Colonna G Pasceri V | 2005 | Circulation2005，111，16： | 1 |
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