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| 1 | Treatment strategies for colorectal carcinoma with synchronous liver metastases: Which way to go?显示文摘AIM: To offer an up-to-date review of all availabletreatment strategies for patients with synchronous colorectal liver metastases(CLM).METHODS: A comprehensive literature search was performed to identify articles related to the management of patients with synchronous CLM. A search of the electronic databases PubMed, MEDLINE, and Google Scholar was conducted in September 2014.The following search terms were used: synchronous colorectal liver metastases, surgery, stage Ⅳ colorectal cancer, liver-first approach, and up-front hepatectomy.These terms were employed in various combinations to maximize the search. Only articles written in English were included. Particular attention was devoted to studies and review articles that were published within the last six years(2009-2014). Additional searches of the cited references from primary articles were performed to further improve the review. The full texts of all relevant articles were accessed by two independent reviewers.RESULTS: Poor long-term outcomes of patients with synchronous CLM managed by a traditional treatment strategy have led to questions about the timing and sequence of possible therapeutic interventions. Thus,alternative paradigms called reverse strategies have been proposed. Presently, there are four treatment strategies available:(1) primary first approach(or traditional approach) comprises resection of the primary colorectal tumor followed by chemotherapy;subsequent liver resection is performed 3-6 mo after colorectal resection(provided that CLM are still resectable);(2) simultaneous resection of the primary colorectal tumor and CLM during a single operation presents intriguing options for a highly select group of patients, which can be associated with significant postoperative morbidity;(3) liver-first(or chemotherapy-first) approach comprises preoperative chemotherapy(3-6 cycles) followed by liver resection,adjuvant chemotherapy, and resection of the primary colorectal tumor(it is best suited for patients withasymptomatic primary tumors and initially unresectable or marginally resectable CLM); and(4) up-front hepatectomy(or 'true' liver-first approach) includes liver resection followed by adjuvant chemotherapy,colorectal resection, and adjuvant chemotherapy(strategy can be offered to patients with asymptomatic primary tumors and initially resectable CLM).CONCLUSION: None of the aforementioned strategies appears inferior. It is necessary to establish individual treatment plans in multidisciplinary team meetings through careful appraisal of all strategies. | Peter Ihnát Petr Vávra Pavel Zonca | 2015 | World Journal of Gastroenterology2015，21，22： | 10 |
| 2 | Preventive effect of a pectic polysaccharide of the common cranberry Vaccinium oxycoccos L. on acetic acid-induced colitis in mice显示文摘AIM: To study isolation and chemical characterization of pectin derived from the common cranberry Vaccinium oxycoccos L. (oxycoccusan OP) and the testing of its preventive effect on experimental colitis.METHODS: Mice were administrated orally with OP two days prior to a rectal injection of 5% acetic acid and examined for colonic damage 24 h later. Colonic inflammation was characterized by macroscopical injury and enhanced levels of myeloperoxidase activity measured spectrophotometrically with o-phenylene diamine as the substrate. The mucus contents of the colon were determined by the Alcian blue dye binding method. Vascular permeability was estimated using 4% Evans blue passage after i.p. injection of 0.05 mol/L acetic acid. RESULTS: In the mice treated with OP, colonic macroscopic scores (1.1 ± 0.4 vs 2.7, P < 0.01) and the total square area of damage (10 ± 2 vs 21 ± 7, P < 0.01) were significantly reduced when compared with the vehicle-treated colitis group. OP was shown to decrease the tissue myeloperoxidase activity in colons (42 ± 11 vs 112 ± 40, P < 0.01) and enhance the amount of mucus of colitis mice (0.9 ± 0.1 vs 0.4 ± 0.1, P < 0.01). The level of colonic malondialdehyde was noted to decrease in OP-pretreated mice (3.6 ± 0.7 vs 5.1 ± 0.8, P < 0.01). OP was found to decrease the inflammatory status of mice as was determined by reduction of vascular permeability (161 ± 34 vs 241 ± 21, P < 0.01). Adhesionof peritoneal neutrophils and macrophages was also shown to decrease after administration of OP (141 ± 50 vs 235 ± 37, P < 0.05).CONCLUSION: Thus, a preventive effect of pectin from the common cranberry, namely oxycoccusan OP, on acetic acid-induced colitis in mice was detected. A reduction of neutrophil infiltration and antioxidant action may be implicated in the protective effect of oxycoccusan. | Sergey V Popov Pavel A Markov Ida R Nikitina Sergey Petrishev Vasily Smirnov Yury S Ovodov | 2006 | World Journal of Gastroenterology2006，12，41： | 9 |
| 3 | Selectivegrowth of SWNTs on partially reduced monometalliccobait catalyst 显示文摘 | Maoshuai H Alexander I C Pavel V F | 2011 | Chem Commun2011，47，： | 1 |
| 4 | Practical management of everolimus-related toxicities in patients with ad- vanced solid tumors显示文摘 | GRUNWALD V WEIKERT S PAVEL ME | 2013 | Onkologie2013，36，5： | 1 |
| 5 | An experimental investigation of capsules of anomalous shape conveyed by liquid in a pipe 显示文摘 | Pavel V | 1999 | Powder Technology1999，104，3： | 1 |
| 6 | New alternating copolyimides by high temperature synthesis in benzoic acid medium显示文摘 | Alexander A K Marina Y Y Pavel V B | 2004 | High Performance Poly?mers2004，16，： | 1 |
| 7 | Characterization and remediation of soils contaminated with uranium 显示文摘 | Gavrilescu M Pavel L V Cretescu I | 2008 | Journal of Hazardous Materials2008，163，7： | 1 |
| 8 | Resonant transformation of modes in oversize electrodynamic systems 显示文摘 | Malygin S A Pavel'ev V G Tsimring S E | 1983 | Radiophysics and Quantum Electronics1983，26，9： | 1 |
| 9 | The expression and role of insulin-like growth factor Ⅱ in malignant hemangiopericytomas显示文摘 | Pavelic K Spaventi S Gluncic V | 1999 | J Mol Med1999，77，12： | 1 |
| 10 | Coupled resonator gyrotrons with mode conversion显示文摘 | Zapevalov V E Malygin S A Pavel'ev V G | 1984 | Radiophys Quantum Electron1984，27，： | 1 |
| 11 | Synthesis and some properties of substituted 4-azafluorenes显示文摘 | Paver G V Pavel K G Tilichenko M N | 1990 | Chemistry of Heterocyclic Compounds1990，26，7： | 1 |
| 12 | Laser emission under resonant pump in the emitting level of concentrated Nd:YAG ceramics显示文摘 | LUPEI V LUPEI A PAVEL N | 2001 | Appl Phys Lett2001，79，5： | 1 |
| 13 | Characterization and remediation of soils contaminated with uranium显示文摘 | Gavrilescu M Pavel L V Cretescu I | 2009 | Jour- nal of Hazardous Materials2009，163，23： | 1 |
| 14 | Shevchenko Impact of insurance for operational risk: Is it worthwhile to insure or be in- sured for severe losses? 显示文摘 | W P Gareth D 13 Aaron V Pavel | 2011 | Insurancez Mathematics and Eco- nomics2011，48，2： | 1 |
| 15 | Highly efficient 1063-nm continuous-wave laser emission in Nd: GdVO4 显示文摘 | Luper V Pavel N Sato Y | 2003 | OptLett2003，28，： | 1 |
| 16 | Characterization and remediation of soils contaminated with uranium 显示文摘 | GAVRILESCU M PAVEL L V CRETESCU I | 2009 | J Hazard Mater2009，163，23： | 1 |
| 17 | True blue:Blue-emitting aluminum(III) quinolinolate complexes显示文摘 | Cesar P B Montes V A Pavel A | | 0，，24： | 1 |
| 18 | Experimental and computed temperature histories in gas tungsten arc welding of thin plates显示文摘 | PAVELIC V TANBAKUCHI R UYEHARA O A etal | 1969 | Weld Journal1969，48，： | 1 |
| 19 | Crystal structure and physical properties of the new 2 D polymeric compound bis ( 1, 5-diaminotetrazole) dichlorocopper ( II)显示文摘 | Pavel N Gaponik Sergei V Voitekhovich Alexander S Lyakhov | 2005 | Inorganica Chimica Acta2005，358，： | 1 |
| 20 | Probabilistic evaluation of initiation time ofchloride-induced corrosion 显示文摘 | VAL D V PAVEL A T | 2008 | Reliability Engineering and SystemSafety2008，，93： | 1 |
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