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| 1 | Meta-analyses on prevalence of selected Parkinson’s nonmotor symptoms before and after diagnosis显示文摘Background:Nonmotor symptoms are common among patients with Parkinson’s disease(PD)and some may precede disease diagnosis.Methods:We conducted a meta-analysis on the prevalence of selected nonmotor symptoms before and after PD diagnosis,using random-effect models.We searched PubMed(1965 through October/November 2012)for the following symptoms:hyposmia,constipation,rapid eye movement sleep behavior disorder,excessive daytime sleepiness,depression,and anxiety.Eligible studies were publications in English with original data on one or more of these symptoms.Results:The search generated 2,373 non-duplicated publications and 332 met the inclusion criteria,mostly(n=320)on symptoms after PD diagnosis.For all symptoms,the prevalence was substantially higher in PD cases than in controls,each affecting over a third of the patients.Hyposmia was the most prevalent(75.5%in cases vs.19.1%in controls),followed by constipation(50%vs.17.7%),anxiety(39.9%vs.19.1%),rapid eye movement sleep behavior disorder(37.0%vs.7.0%),depression(36.6%vs.14.9%),and excessive daytime sleepiness(33.9%vs.10.5%).We observed substantial heterogeneities across studies and meta-regression analyses suggested that several factors might have contributed to this.However,the prevalence estimates were fairly robust in several sensitivity analyses.Only 20 studies had data on any symptoms prior to PD diagnosis,but still the analyses revealed higher prevalence in future PD cases than in controls.Conclusion:These symptoms are common among PD patients both before and after diagnosis.Further studies are needed to understand the natural history of nonmotor symptoms in PD and their etiological and clinical implications. | Honglei Chen Edward J Zhao Wen Zhang Yi Lu Rui Liu Xuemei Huang Anna J Ciesielski-Jones Michele A Justice Deborah S Cousins Shyamal Peddada | 2015 | Translational Neurodegeneration2015，4，1： | 18 |
| 2 | Order-restricted inference for ordered gene expression(OPIOGEN)data under heteroscedastic variances显示文摘 | SIMMONS S PEDDADA S | 2007 | Bioinformatics2007，1，10： | 1 |
| 3 | Statistical inference in nonli-near regression under heteroscedasticity显示文摘 | Lim C Sen P K Peddada S D | 2010 | Sankhya B2010，72，： | 1 |
| 4 | Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes 显示文摘 | Yasui DH Peddada S Bieda MC | 2007 | Proc Natl Acad Sci U S A2007，104，19： | 1 |
| 5 | Assessment of lead exposure and associated risk factors in urban children in Silesia, Poland 显示文摘 | Jarosinska D Peddada S Rogan W J | 2004 | Environmental Research2004，95，： | 1 |
| 6 | Nickel hexacya noferrate nanopartiele electrodes for aqueous sodium and potas- sium ion batteries显示文摘 | Wessells C D Peddada S V Huggins R A | 2011 | Nano Letters2011，11，12： | 1 |
| 7 | Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes显示文摘 | Yasui DH Peddada S Bieda MC | 2007 | Proc Natl Acad Sci USA2007，104，19： | 1 |
| 8 | Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-rmge interaction with active genes 显示文摘 | Yasui DH Peddada S Bieda MC | 2007 | Proc Natl Acad Sci U S A2007，104，19： | 1 |
| 9 | Gene selection and clustering for time-course and dose-response microarray experiments using order-restricted inference显示文摘 | PEDDADA S LOBENHOFER E LI L | 2003 | Bioinformatics2003，19，： | 1 |
| 10 | Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes 显示文摘 | Yasui DH Peddada S Bieda MC | 2007 | Proc Natl Acad Sci USA2007，104，19： | 1 |
| 11 | Reduced sulfur mustard-induced skin toxicity in cyclooxygenase-2 knockout and celecoxib-treated mice 显示文摘 | Wormser U Langenbach K Peddada S | 2004 | Toxicol Appl Phatmacol2004，200，1： | 1 |
| 12 | Assessment of lead exposure and associated risk factors in urban children in Silesia,Poland显示文摘 | Jarosinska D Peddada S Rogan W J | 2004 | Environ Res2004，95，2： | 1 |
| 13 | Assessment of lead exposure and associated risk factors in urban children in Silesia,Poland显示文摘 | Jarosinska D Peddada S Rogan WJ | 2004 | Environ Res2004，95，2： | 1 |
| 14 | Nickel hexacyanoferrate nanoparticle electrodes for aqueous sodium and potassium ion batteries显示文摘 | WESSELLS C D PEDDADA S V HUGGINS R A | 2011 | Nano Letters2011，11，12： | 1 |
| 15 | Consistency of a class of variance estimators in linear models under heteroscedasticity显示文摘 | Peddada S D Smith T A | 1997 | Sankhya1997，59，： | 1 |
| 16 | Analysis of fixed effects linear models under heteroscedastic errors显示文摘 | Smith T A Peddada S D | 1998 | Statistics and Probability Letters1998，37，4： | 1 |
| 17 | Confidence Interval Estimation Subject to Order Restrictions 显示文摘 | Hwang J T Peddada S D | 1994 | Ann Statist1994，22，： | 1 |
| 18 | Reduced sulfur mustard-induced skin toxicity in cyclooxygenase-2 knockout and celecoxib-treated mice显示文摘 | Worrser U Langenbach R Peddada S | 2004 | Toxicol Appl Pharmacol2004，200，1： | 1 |
| 19 | Confidence interval estimation subject to order restrictions显示文摘 | Peddada S D | 1994 | Ann Statist1994，22，： | 1 |
| 20 | Confidence interval estimation subject to order restrictions显示文摘 | HWANG J T G PEDDADA S D | 1994 | Ann Statist1994，22，： | 1 |
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