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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Study on Steel-Mushy Al-20Sn Alloy Bonding显示文摘Steel-mushy Al-20Sn alloy bonding was studied for the first time. The relationship model about preheat temperature of steel plate, solid fraction of Al-20Sn alloy mushy, rolling speed and interfacial shear strength of bonding plate could be established by artificial neural networks perfectly. This model could be optimized with a genetic algorithm. The optimum bonding parameters were: 505’C for preheat temperature of steel plate, 34.3% for solid fraction of Al20Sn alloy musry and 10 mm/s for rolling speed, and the largest interfacial shear strength of bonding plate was 71.2 MPa. | Peng ZHANG, Yunhui DU and Daben ZENG Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China Jianzhong CUI Metal Forming Department, NEU, Shenyang 110006, China Limin BA Anshan Automobile Fittings Factory, Anshan 114014, China | 2001 | Journal of Materials Science & Technology2001，17，2： | 7 |
| 3 | Drilling Combined with Adipose-derived Stem Cells and Bone Morphogenetic Protein-2 to Treat Femoral Head Epiphyseal Necrosis in Juvenile Rabbits显示文摘 | Zi-li WANG Rong-zhen HE Bin TU Jin-shen HE Xu CAO Han-song XIA Hong-liang BA Song WU Cheng PENG Kun XIONG | 2018 | Current Medical Science2018，38，2： | 7 |
| 4 | Large-area high quality PtSe2 thin film with versatile polarity显示文摘Two-dimensional(2D)materials have attracted increasing attention for their outstanding structural and electrical properties.However,for mass-production of field effect transistors(FETs)and potential applications in integrated circuits,large-area and uniform 2D thin films with high mobility,large on-off ratio,and desired polarity are needed to synthesize firstly.Here,a transfer-free growth method for platinum diselenide(PtSe2)films has been developed.The PtSe2 films have been synthesized with various thicknesses in centimeter-sized scale.Typical FET made from a few layer PtSe2 show p-type unipolar,with a high field-effect hole mobility of 6.2 cm^(2) V^(−1) s^(−1) and an on-off ratio of 5×10^(3).The versatile semimetal-unipolar-ambipolar transition in synthesized PtSe2 films is also firstly observed as the thickness thinning.This work realizes the large-scale preparation of PtSe2 with prominent electrical properties and provides a new strategy for polarity's modulation. | Wei Jiang Xudong Wang Yan Chen Guangjian Wu Kun Ba Ningning Xuan Yangye Sun Peng Gong Jingxian Bao Hong Shen Tie Lin Xiangjian Meng Jianlu Wang Zhengzong Sun | 2019 | InfoMat2019，1，2： | 5 |
| 5 | Low-cost solid FeS lubricant as a possible alternative to MoS2 for producing Fe-based friction materials显示文摘Three reaction systems of MoS_2–Fe, FeS –Fe, and Fe S–Fe–Mo were designed to investigate the use of FeS as an alternative to MoS_2 for producing Fe-based friction materials. Samples were prepared by powder metallurgy, and their phase compositions, microstructures, mechanical properties, and friction performance were characterized. The results showed that MoS_2 reacts with the matrix to produce iron-sulfides and Mo when sintered at 1050°C. Iron-sulfides produced in the MoS_2–Fe system were distributed uniformly and continuously in the matrix, leading to optimal mechanical properties and the lowest coefficient of friction among the systems studied. The lubricity observed was hypothesized to originate from the iron-sulfides produced. The Fe S–Fe–Mo system showed a phase composition, porosity, and density similar to those of the MoS_2–Fe system, but an uneven distribution of iron-sulfides and Mo in this system resulted in less-optimal mechanical properties. Finally, the Fe S–Fe system showed the poorest mechanical properties among the systems studied because of the lack of Mo reinforcement. In friction tests, the formation of a sulfide layer contributed to a decrease in coefficient of friction(COF) in all of the samples. | Tao Peng Qing-zhi Yan Yan Zhang Xiao-jiao Shi Ming-yang Ba | 2017 | International Journal of Minerals,Metallurgy and Materials2017，24，1： | 4 |
| 6 | Penile prosthesis implantation in Chinese patients wit severe erectile dysfunction: 10-year experience显示文摘我们回顾地与严重可勃起的机能障碍(SED ) 在中国病人评估了阴茎修复术培植(PPI ) 的临床的结果。从 2000 年 7 月到 2011 年 12 月, 224 个病人(吝啬的年龄:35.9 ± 11.8 年,变化:20-75 年) 在我们的中心根据标准 PPI 过程由富有经验的外科医生与 SED 经历了 PPI。韧性的修复术(AMS 650 ) 在 45 种情况中被植入(20.1 %) ,并且三片的可膨胀的修复术(AMS 700 CXM 或 AMS 700 CXR ) 在 179 种情况中被植入(79.9 %) 。包括手术后的复杂并发症,临床的功效和夫妇满足,外科的结果被评估在上比手术后地使用医药记录抽象的 6 个月, IIEF-5,生活(QoL ) 的质量分数,和病人 / 搭挡的性满足分数由 Bhojwani 等求婚了。为学习合格的 224 个病人, 201 使遭到(89.7 %) 完成的后续。所有能与吝啬的手术后的 IIEF-5 病人执行性交柱子 PPI, QoL 分数是 20.02 ± 2.32 和 5.28 ± 0.76,分别地它显著地与外科手术前的分数相比被改进(6.29 ± 1.5 和 2.13 ± 0.84, P< 0.01 ) 。201 个人,机械失灵发生在四种情况中(2.0 %) 并且三个盒子被重新植入新设备,和二个盒子(1.0 %) 开发了阴茎的温和弯曲。有感染的阴囊的侵蚀与糖尿病 mellitus 发生在一种情况中(0.5 %) 并且植入的 AMS 的要求的完全的移动 700 CXM。令人满意的性交被 178 个人两次至少每月报导(88.6 %) ,并且对 PPI 外科的全面满足被 89.0 % 报导;人和 82.5 %搭挡。在三片的可膨胀的修复术组的耐心的满足比在韧性的修复术组高(P< 0.05 ) 。然而,在 prostheses 的类型之间,满足没在搭挡调查不同。PPI 是一种安全、有效的治疗选择因为有 SED 和富有经验的外科医生的中国病人根据标准 PPI 执行 PPI 过程能减少 PPI 的手术后的复杂并发症并且能改进耐心的满足比率和 QoL。 | Wei-Dong Song Yi-Ming Yuan Wan-Shou Cui Alex K Wu Yi-Chen Zhu Jing Liu Lin Wang Guang-Yi Ba Jing Peng Zhi-Chao Zhang Bing Gao Ying-Lu Guo Tom F Lue Zhong-Cheng Xin | 2013 | Asian Journal of Andrology2013，15，5： | 3 |
| 7 | Immersing Treatment of Steel Plate Surface in Steel-Aluminum Solid to Liquid Bonding显示文摘The interfacial status of the steel-aluminum solid to liquid bonding plates (their steel plate surfaces were or were not immersed in flux aqueous solution) were measured by using SEM (Scanning Electron Microscope) and X-ray diffraction . The results showed that the layer of flux (the minimum thickness was 15 μm on the steel plate surface) could protect the steel plate surface from oxidizing effectively at high temperature in solid to liquid bonding. The melt temperatUre of the flux should be lower than 580 ℃ so that it could be melted and removed completely. No. 1 flux (patent product made by the author) made up of halogeindes could also force liquid aluminum to infiltrate into steel plate surface and thus the interfacial shear strength of the bonding plate was rather large. | Peng Zhang Yunhui Du Xueping Ren Yonglin Kang Hanwu Liu Jianzhong Cui Limin Ba (Material Science and Engineering School, University of Science and Technique Beijing, Beijing 100083, China)(Metal Forming Department Northeastern University, Shenyang 1 | 1999 | International Journal of Minerals,Metallurgy and Materials1999，13，1： | 2 |
| 8 | Antioxidant activity of peptide fractions from whey protein hydrolysates as measured by electron spin resonance显示文摘 | Peng XA Xiong YC Kong BA | | 0，，： | 1 |
| 9 | Antioxidant activity ofpeptide fractions from whey protein hydrolysates asmeasured by electron spin resonance 显示文摘 | Peng XA Xiong YC Kong BA | 2009 | Food Chemistry2009，113，： | 1 |
| 10 | The self-assembly behaviors of Ti O2nanotree in dendri-tic PAMAM template显示文摘 | ZHENG Peng BA Xinwu ZHAO Junchai | 2015 | Colloid and Polymer Science2015，293，1： | 1 |
| 11 | Rotary power-flow controller for dynamic performance evaluation Part II: RPFC application in a transmission corridor显示文摘 | Ba A O Peng T Lefebvre S | 2009 | IEEE Transactions on Power Delivery2009，24，3： | 1 |
| 12 | Rotary power-flow controller for dynamic performance evaluation-part I:RPFC modeling显示文摘 | Ba A O Tao Peng Lefebvre S | 2009 | IEEE Trans on Power Delivery2009，24，3： | 1 |
| 13 | Rotary power-flow controller for dynamic performance evaluation-part II:RPFC application in a transmission corridor显示文摘 | Ba A O Tao Peng Lefebvre S | 2009 | IEEE Trans on Power Delivery2009，24，3： | 1 |
| 14 | Cholelithiasis and risk of pancreatic cancer: systematic review and meta-analysis of 21 observational studies显示文摘 | Yuanfeng Gong Siying Li Yunqiang Tang Cong Mai Mingchen Ba Peng Jiang Hui Tang | 2014 | Cancer Causes & Control2014，，： | 1 |
| 15 | Transduction of tumor-specific T cells with CXCR2 chemokine receptor improvesmigration to tumor and antitumor immune responses 显示文摘 | Peng W Ye Y Rabinovich BA | 2010 | ClinCancer Res2010，16，22： | 1 |
| 16 | Ionic liquid (molten salt): Thermoregulated catalyst support for catalytic hydrosilylation process 显示文摘 | PENG J J LI J Y BA! Y | 2008 | Catal Commun2008，9，： | 1 |
| 17 | Semi-solid processing of steel-Al-7 graphite binding plate显示文摘 | Zhang Peng Du Yun-hui Xing Shu-ming Zhang Li-zhong Zeng Da-ben Ba Li-min | 2002 | Journal of Wuhan University of Technology - Mater Sci Ed2002，，3： | 1 |
| 18 | Development of molecularly imprinted polymer films used for de- tection of profenofos based on a quartz crystal mi- crobalanee sensor 显示文摘 | Gao N Dong JW Liu M Ning BA Cheng CN Guo C Zhou CH Peng Y Bai JL Gao ZX | 2012 | Analyst2012，137，： | 1 |
| 19 | 显示文摘 | Ba H Chen D | 1992 | Electrochim1992，37，： | 1 |
| 20 | Pharmacokinetically guided dosing of carboplatin and etopoise during peritoneal dialysis and haemodialysis 显示文摘 | ENGLISH MW LOWIS SP PENG BA | 1996 | British J of Can1996，73，： | 1 |
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