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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | 兼具双面黏性和生物活性的多功能水凝胶显示文摘用于创伤愈合以及软组织修复创新点水凝胶是一种具有三维交联网络的生物医用材料,既可以作为机体保护屏障防止细菌感染,又能为组织再生提供合适的微环境。对机体组织和植入物具有双面黏性的水凝胶具有巨大的临床应用潜力。一方面,对组织具有高黏合性的水凝胶可以把受损组织黏合在一起,防止因常规缝合引起的瘢痕组织形成。 | GAO L ZHOU Y L PENG J L | 2019 | 张江科技评论2019，0，6： | 9 |
| 3 | Interleukin-1α, 6 regulate the secretion of vascular endothelial growth factor A, C in pancreatic cancer显示文摘Vascular endothelial growth factor (VEGF, namely VEGF-A) is an angiogenic polypeptide and VEGF-C is a lymphangiogenic polypeptide that has been implicated in cancer growth, invasion and metastasis. Several cytokines and growth factors play an important part in cancer progression. These cytokines and growth factors are the principal mediators of cancer cells-stromal cell interaction , which is critical for invasion of cancer cells to the surrounding tissues and metastatic dissemination to distant organs. In this study, we studied VEGF-A, C expression in cultured human pancreatic cancer cell lines and whether the presence of VEGF-A, C in the cell lines is regulated by cytokines interleukin-lct (EL-1α), and interleukin-6 (IL-6). METHODS: We used Northern blot and Western blot methods to analyze expression of the gene and protein of VEGF-A, C in all 6 tested cell lines (ASPC-1, CAPAN-1, MIA-PaCa-2, PANC-1, COLO-357 and T3M4) respectively. To analyze what is the regulator for this VEGF-A, C expression in pancreatic cancer,we used the reverse transcription -polymerase chain reaction (RT-PCR) method to analyze VEGF-A, C expression in cultured human pancreatic cancer cell lines (CAPAN-1 and COLO-357) under the stimulation with IL-1α (10μg/L) or IL-6 (100 μg/L). RESULTS:Northern blot analysis revealed the presence of the 4.1-kb VEGF-A mRNA transcript and 2.4-kb VEGF-C mRNA transcript in all 6 tested cell lines. Immunoblotting with highly specific anti-VEGF-A, anti-VEGF-C antibody revealed the presence of a molecular weight of 43-kDa VEGF-A protein and 55-kDa VEGF-C protein in all the cell lines. RT-PCR analysis revealed the levels of the VEGF-A and VEGF-C gene were 1-2 fold and a 1-fold increase in the COLO-357 cell line by stimulation with IL-la, however, no effect was found in the CAPAN-1 cell line. The levels of the VEGF-A and VEGF-C gene were 2-5 fold and a 1-fold increase in the CAPAN-1 cell line by stimulation with IL-6, but, no effect was found in the COLO-357 cell line. CONCLUSION:These findings suggested that the expression of VEGF-A, C and their regulation by IL-1α, IL-6 in pancreatic cancer contributes to the lymphatic and distant metastasis and the disease progression. | Department of Hepatobiliary Surgery (Tang RF, Zhang FR, Peng L, Wang SX, Xiao Y and Zhang M) and Department of Dermatology (Wang SX), 4th Hospital, Hebei Medical University, Shijiazhuang 050011, China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 6 |
| 4 | High alpha-fetoprotein level correlates with high stage, early recurrence and poor prognosis of hepatocellular carcinoma : significance of hepatitis virus infection ,age ,p53 ,and beta-catenin mutations显示文摘 | PENG S Y CHEN W J LAI P L | 2004 | Int J Cancer2004，112，1： | 1 |
| 5 | Reaction of N-methyl-2-pyrrolidinone with carbon disulfide显示文摘 | Zong Z M Peng Y L Qin Z H | 2000 | Energy Fuels2000，14，3： | 1 |
| 6 | 显示文摘 | Wang Y Y Peng W J Chai L Y | 2004 | J Cent Southuniv Technol2004，11，4： | 1 |
| 7 | PBDEs in sediments of the Beijiang River,China: levels,distribution,and influence of total organic carbon 显示文摘 | CHEN L G HUANG Y M PENG X C | 2009 | Chemosphere2009，76，2： | 1 |
| 8 | Shaping carbon nanotubes and the effects on their electrical and mechanical properties显示文摘 | Wang M S Peng L M Wang J Y | 2006 | Adv Funct Mater2006，16，11： | 1 |
| 9 | An Optimization Method Inspired by Chaotic Ant Behavior 显示文摘 | LI L X YANG Y X PENG H P | 2006 | Internation- al Journal of Bifurcation Chaos2006，，16： | 1 |
| 10 | Vibration signal analysis and feature extraction based on reassigned wavelet scalogram显示文摘 | Peng Z K Chu F L He Y Y | 2002 | Journal of Sound and Vibration2002，253，5： | 1 |
| 11 | A nonlinear control for enhancing HVDC light transmission system stability显示文摘 | Ruan S Y Li G J Peng L | 2007 | International Journal of Electrical Power and Energy Systems2007，29，7： | 1 |
| 12 | CCCH-type zinc finger fam- ily in maize:genome-wide identi{ication, classification and ex- pression profiling under abscisic acid and drought treatments 显示文摘 | Peng X J Zhao Y Cao J G et a l | 2012 | PLoS One2012，7，40： | 1 |
| 13 | Study on combined control of regenerative braking and antilock braking system for hy- brid electric vehicles 显示文摘 | Peng D Zhang Y Yin C L | 2008 | International Journal of Automo- tive Technology2008，9，6： | 1 |
| 14 | Preparation and properties of high purity Mg-Y biomaterials显示文摘 | Peng Q M Huang Y D Zhou L Hort N Kainer K U | | 0，，： | 1 |
| 15 | The prevalence of parasites and pathogens in Asian honeybees Apis cerana in China显示文摘 | Li J L Qin H R Wu J Sadd B M Wang X Evans J D Peng W Chen Y | 2012 | PLoS One2012，7，47： | 1 |
| 16 | 显示文摘 | Niu X Z Peng S L Liu L Y | 2007 | Advanced Materials2007，19，18： | 1 |
| 17 | Antioxidant activity of peptide fractions from whey protein hydrolysates as measured by electron spin resonance显示文摘 | Peng X Y Xiong Y L Kong B H | 2009 | Food Chemistry2009，113，： | 1 |
| 18 | Os AAP6 functions as an important regulator of grain protein content and nutritional quality in rice显示文摘 | Peng B Kong H L Li Y B | 2014 | Nature Communications2014，5，： | 1 |
| 19 | Application of preparative high-speed counter-current chromatography for isolation and separation of schizandrin and gomisin A from Schisandra chinensis显示文摘 | Peng J Y Fan G R Qu L P | 2005 | J Chromatogr A2005，1082，2： | 1 |
| 20 | High temperature creepdeformation of A118B4O33 whisker-reinforced 8009 Al composite显示文摘 | L M Peng S J Zhu Z Y Ma | 1999 | Materials Science and Engineering1999，265，： | 1 |
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