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| 1 | Differential colorectal carcinogenesis:Molecular basis and clinical relevance显示文摘Colorectal cancer(CCR) is one of the most frequent cancers in developed countries.It poses a major public health problem and there is renewed interest in understanding the basic principles of the molecular biology of colorectal cancer.It has been established that sporadic CCRs can arise from at least two different carcinogenic pathways.The traditional pathway,also called the suppressor or chromosomal instability pathway,follows the Fearon and Vogelstein model and shows mutation in classical oncogenes and tumour suppressor genes,such as K-ras,adenomatous polyposis coli,deleted in colorectal cancer,or p53.Alterations in the Wnt pathway are also very common in this type of tumour.The second main colorectal carcinogenesis pathway is the mutator pathway.This pathway is present in nearly 15% of all cases of sporadic colorectal cancer.It is characterized by the presence of mutations in the microsatellite sequences caused by a defect in the DNA mismatch repair genes,mostly in hMLH1 or hMSH2.These two pathways have clear molecular differences,which will be reviewed in this article,but they also present distinct histopathological features.More strikingly,their clinical behaviours are completely different,having the 'mutator' tumours a better outcome than the 'suppressor' tumours. | Alberto Morán Paloma Ortega Carmen de Juan Tamara Fernández-Marcelo Cristina Frías Andrés Sánchez-Pernaute Antonio José Torres Eduardo Díaz-Rubio Pilar Iniesta Manuel Benito | 2010 | World Journal of Gastrointestinal Oncology2010，2，3： | 5 |
| 2 | EUS-guided single-incision needle-knife biopsy: description and results of a new method for tissue sampling of subepithelial GI tumors (with video)显示文摘 | Carlos de la Serna-Higuera Manuel Pérez-Miranda Pilar Díez-Redondo Paula Gil-Simón Teresa Herranz Elena Pérez-Martín C. Ochoa Agustín Caro-Patón | 2011 | Gastrointestinal Endoscopy2011，，3： | 2 |
| 3 | Develop-meat of an enzymeless biosensor for the determination of phenolic compounds 显示文摘 | PILAR M D SOTOM T TANAKA A A | 2002 | Anal Chim Acta2002，455，： | 1 |
| 4 | Dissolving polymer microneedle patches for influenza vaccina- tion显示文摘 | Sullivan S P Koutsonanos D G del Pilar Martin M | 2010 | Nat Med2010，16，8： | 1 |
| 5 | Pyrrolidine dithiocarbamate protects mice from Lethal shock induced by LPS or TNF-α显示文摘 | PILAR L SARA M M PABBO C D et al | 1999 | Eur J Immunol1999，29，6： | 1 |
| 6 | Refractory hepatic encephalopathy in a patient with hypothyroidism: Another element in ammonia metabolism显示文摘Hepatic encephalopathy(HE) remains a diagnosis of exclusion due to the lack of specific signs and symptoms. Refractory HE is an uncommon but serious condition that requires the search of hidden precipitating events(i.e.,portosystemic shunt) and alternative diagnosis. Hypothyroidism shares clinical manifestations with HE and is usually considered within the differential diagnosis of HE. Here,we describe a patient with refractory HE who presented a large portosystemic shunt and post-ablative hypothyroidism. Her cognitive impairment,hyperammonaemia,electroencephalograph alterations,impaired neuropsychological performance,and magnetic resonance imaging and spectroscopy disturbances were highly suggestive of HE,paralleled the course of hypothyroidism and normalized after thyroid hormone replacement. There was no need for intervention over the portosystemic shunt. The case findings support that hypothyroidism may precipitate HE in cirrhotic patients by inducing hyperammonaemia and/or enhancing ammonia brain toxicity. This case led us to consider hypothyroidism not only in the differential diagnosis but also as a precipitating factor of HE. | Fernando Díaz-Fontenla Marta Castillo-Pradillo Arantxa Díaz-Gómez Luis Ibanez-Samaniego Pilar Gancedo Juan Adan Guzmán-de-Villoria Pilar Fernández-García Rafael Banares-Canizares Rita García-Martínez | 2017 | World Journal of Gastroenterology2017，23，28： | 1 |
| 7 | Dietary polyunsatured fatty acids (PUFA) differentially modulate melamineinduced preneoplastic urothelial proliferation and apoptosis in mice显示文摘 | CREMONEZZI D C SILVA R A DEL PILAR D M | 2001 | Prostaglandins Leukot Essent Fatty Acids2001，64，3： | 1 |
| 8 | Non-destructive detection of hollow heart in potatoes using hyperspectral imaging显示文摘 | Angel D N Arno F Pilar C | 2011 | Image Analysis and Processing2011，6855，1： | 1 |
| 9 | Rainfall partitioning by vegetation un der Mediterranean conditions:A review of studies in Europe 显示文摘 | Pilar L Francisco D | 2007 | Journal of Hydrology2007，335，12： | 1 |
| 10 | Rural tourism demand by type of accommodation显示文摘 | ISABEL PILAR ALBALADEJO PINA MAP(I)A TERESA D(I)AZ DELFA | 2005 | Tourism Management2005，26，6： | 1 |
| 11 | Determination of total selenium and selenium distribution in the milk phases in commercial cow's milk by HG-AAS显示文摘 | Cocar M N Raquel D G Adela B B Jos6 A C Jos6 M F Pilar B B | 2005 | Analytical and Bioanalytical Chemistry2005，381，6： | 1 |
| 12 | Plasma S100B level after acute spontaneous intracerebral hemorrhage显示文摘 | Pilar D Jose AS | 2006 | Stroke2006，37，： | 1 |
| 13 | Occurrence of toxic cyanobacterial blooms in San Roque Reservoir (Cordoba,Argentina): a field and chemometric study显示文摘 | Ame M V del Pilar Diaz M Wunderlin D A | 2003 | Environmental Toxicology2003，18，3： | 1 |
| 14 | Dissolving polymer microneedle patches for influenza vaccination 显示文摘 | SULLIVAN S P KOUTSONANOS D G DEL PILAR MARTIN M | 2010 | Nat Med2010，16，8： | 1 |
| 15 | Intracellular processing of proteins mediated by biodegradable polyelectrolyte capsules 显示文摘 | Pilar R G Stefaan D K Bruno G D G | 2009 | Nano Letters2009，9，12： | 1 |
| 16 | Osmoregulatory action of PRL, GH, and cortisol in the gihhead sea bream 显示文摘 | MANCERA M J CARRION R L MARTIN-DEL- PILAR M D R | 2002 | General and Comparative Endocrinology2002，129，2： | 1 |
| 17 | Mineralization of Poly(e-caprolactone)/Adipate Modified Starch Blend in Agricultural Soil显示文摘 | PILAR D S C Mariani ANTONIO P | 2007 | JournM of Polymers and the Environment2007，15，1： | 1 |
| 18 | Patterns of colonization by Pseudomonas aeruginosa in intubated patients: a 3-year prospective study of 1,607 isolates using pulsed-field gel electrophoresis with implications for prevention of ventilator-associated pneumonia显示文摘 | Jordi Vallés Dolors Mariscal Pilar Cortés Pere Coll Ana Villagrá Emili Díaz Antonio Artigas Jordi Rello | 2004 | Intensive Care Medicine2004，，9： | 1 |
| 19 | Dietary polyunsatured fatty acids ( PUFA )differentially modulate melamine- induced preneoplastic urothelial proliferation and apoptosis in mice 显示文摘 | CREMONEZZI D C SILVA R A DEL PILAR DIAZ M | 2001 | Prostaglandins Leukot Essent Fatty Acids2001，64，3： | 1 |
| 20 | miR-133a Enhances the Protective Capacity of Cardiac Progenitors Cells after Myocardial Infarction显示文摘 | Alberto Izarra Isabel Moscoso Elif Levent Susana Ca?ón Inmaculada Cerrada Antonio Díez-Juan Vanessa Blanca Iván-J. Nú?ez-Gil I?igo Valiente Amparo Ruíz-Sauri Pilar Sepúlveda Malte Tiburcy Wolfram-H. Zimmermann Antonio Bernad | 2014 | Stem Cell Reports2014，，： | 1 |
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