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| 1 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 2 | Carbonic anhydrase enzymes Ⅱ, Ⅶ, Ⅸ and Ⅻ in colorectal carcinomas显示文摘AIM To investigate expression of four alpha-carbonic anhydrases(CAs) in colorectal carcinomas(CRC) and compare the results with patients' survival.METHODS Colorectal carcinoma samples from 539 CRC patients and control tissues were arranged as tissue microarrays and analyzed with antibodies against CA Ⅱ, CA Ⅶ, CA Ⅸ, and CA Ⅻ. Intensity and extent of staining were both scored from 0 to 3 in each sample. These enzyme expression levels were then correlated to patients' survival and clinicopathological parameters, which were tumor differentiation grade and stage, site of tumor, patients' age, and gender. Kaplan-Meier analysis and Cox regression hazard ratio model were used to analyze survival data. RESULTS CA Ⅱ and CA Ⅻ staining intensities correlated with patients' survival in that higher expression indicated poorer prognosis. In Cox regression analysis one unit increase in the CA Ⅱ intensity increased the hazard ratio to 1.19 fold(CI: 1.04-1.37, P = 0.009). A significant correlation was also found when comparing CA Ⅻ staining intensity with survival of CRC patients(HR = 1.18, 95%CI: 1.01-1.38, P = 0.036). The extent of CA Ⅻ immunostaining did not correlate to the patients' survival(P = 0.242, Kaplan-Meier analysis). A significant interaction between age group and extent of the CA Ⅱ staining was found. Increased extent of CA Ⅱ had a significant hazard ratio among patients 65 years and older(1.42, 95%CI: 1.16-1.73, P = 0.0006). No correlations were found between CA Ⅶ(intensity P = 0.566, extent P = 0.495, Kaplan-Meier analysis), or CA Ⅸ(intensity P = 0.879, extent P = 0.315, KaplanMeier analysis) immunostaining results and survival, or the other parameters. CONCLUSION The present findings indicate that CA Ⅱ and CA Ⅻ could be useful in predicting survival in CRC. | Pia Viikil? Antti J Kivel? Harri Mustonen Selja Koskensalo Abdul Waheed William S Sly Jaromir Pastorek Silvia Pastorekova Seppo Parkkila Caj Haglund | 2016 | World Journal of Gastroenterology2016，22，36： | 3 |
| 3 | Determination of basal ileal endogenous losses and standardized ileal digestibility of amino acids in barley fed to growing pigs显示文摘Background: Basal ileal endogenous amino acid(AA) losses(IAA_(end)) and standardized ileal digestibility(SID) values of cereal grains, such as barley, are apparently underestimated when determined according to the nitrogen(N)-free method. Regression analysis between the dietary apparent ileal digestible content(c AID) and total crude protein(CP) and AA can be considered as alternative approach to obtain more accurate values for IAA_(end)and SID of AA in cereal grains.Methods: Eight hulled barley genotypes were used, with barley being the only source of CP and AA in the assay diets. The diets contained 95 % as-fed of these eight barley genotypes each, ranging in CP content between 109.1 and 123.8 g/kg dry matter(DM). Nine ileally T-cannulated barrows, average body weight(BW) 30 ± 2 kg, were allotted to a row-column design comprising eight periods with 6 d each and nine pigs. On d 5 and the night of d 6 of every period, ileal digesta were collected for a total of 12 h. The IAA_(end) and the SID were determined by linear regression analysis between c AID and total dietary CP and AA.Results: There exist linear relationships between cA ID and total CP and AA(P < 0.001). The IAA_(end) of CP, Lys, Met, Thr and Trp amounted to 35.34, 1.08, 0.25, 1.02 and 0.38 g/kg DM intake(DMI), respectively, which are greater compared to average IAA_(end) determined previously under N-free feeding conditions. The SID of CP, Lys, Met, Thr and Trp was 90,79, 85, 79 and 86 %, respectively, and was greater when compared to tabulated values. Moreover, these SID values were greater than those reported in literature, based on correction of apparent ileal digestibility(AID) of CP and AA for their IAA_(end)values. Summarized, the results of the present regression analysis indicate greater IAA_(end)in barley-based diets compared to those obtained by N-free feeding.Conclusions: For low-protein feed ingredients like barley the regression method may be preferred over correction of AID values for their IAA_(end)determined under N-free feeding conditions, as intercepts and slopes of the linear regression equations between cA ID and total dietary CP and AA provide direct estimates of IAA_(end)and SID of CP and AA in the presence of the assay feed ingredient. | Hanna Katharina Spindler Rainer Mosenthin Pia Rosenfelder Henry J?rgensen Knud Erik Bach Knudsen Meike Eklund | 2017 | Journal of Animal Science and Biotechnology2017，8，1： | 2 |
| 4 | Treatment of alopecia areata in C3H/HeJ mice with the topicalimmunosup- pressant FKS06(TacroLimus) 显示文摘 | Pia F P Andreas Z Kevin J | 2010 | European Journal of Dermatology2010，11，5： | 1 |
| 5 | Exome sequencing in diagnostic evaluation of colorectal cancer predisposition in young patients显示文摘 | Tomas Tanskanen Alexandra E. Gylfe Riku Katainen Minna Taipale Laura Renkonen-Sinisalo Jukka-Pekka Mecklin Heikki J?rvinen Sari Tuupanen Outi Kilpivaara Pia Vahteristo Lauri A. Aaltonen | 2013 | Scandinavian Journal of Gastroenterology2013，，6： | 1 |
| 6 | A survey and comparison of peer-to-peer network schemes 显示文摘 | LUA E K CROWCORFT J PIAS M | 2005 | Journal of IEEE Communications Survey and Tutorial2005，7，2： | 1 |
| 7 | Assignment of the ^13C and ^16N NMR spectra of the antitumour antibiotic streptonigrin 显示文摘 | Pia I A Ian J L Margaret M H | 2002 | Magn Reson Chem2002，40，4： | 1 |
| 8 | A survey and comparison of peer-to-peer overlay network schemes 显示文摘 | Lua E K Crowcroft J Pias M | 2005 | IEEE Comm Survey Tutorial2005，7，2： | 1 |
| 9 | A survey and comparison of peeto peer overlay network schemes显示文摘 | Lua E K Crowcroft J Pias M | 2005 | Communications Surveys & Tutorials2005，7，2： | 1 |
| 10 | Role of plantcover and stock trampling on runoff and soil-erosionfrom semiarid wooded rangelands显示文摘 | Greene RSB Kinnell PIA Wood J T | 1994 | Soil Research1994，32，5： | 1 |
| 11 | Tinidazole:a classical anaerobical drug with multiple potential usesnowadays显示文摘 | Granizo J J Pia Rodicio M Manso F J | 2009 | Rev Esp Quimioter2009，22，2： | 1 |
| 12 | A survey and comparison of peer-to-peer overlay network mechanisms 显示文摘 | Lua E K Crowcroft J Pias M | 2005 | IEEE Communnications Survey and Tutorial2005，7，2： | 1 |
| 13 | A survey and comparison of peer-to-peer overlay network schemes 显示文摘 | Lua E K Crowcroft J Pias M | 2005 | IEEE Communications Survey and Tutorials2005，，2： | 1 |
| 14 | Airway remodeling and lack ot bronchodilator response in steroid- resistant asthma 显示文摘 | Coleva E Pia J Boguniewicz J | 2007 | Allergy Clin Immunol2007，120，5： | 1 |
| 15 | Oligogyny by unrelated queens in the carpenter ant, Camponotus ligniperdus显示文摘 | Jürgen Gadau Pia J. Gertsch Jürgen Heinze Pekka Pamilo Bert H?lldobler | 1998 | Behavioral Ecology and Sociobiology1998，，1： | 1 |
| 16 | A survey and comparison of peer-to-peer overlay network schemes显示文摘 | LUA E K CROWCROFY J PIAS M | 2004 | tEEE Communications Survey and Tutorial2004，7，2： | 1 |
| 17 | Three monocyto-related determinants of atherosclerosis in haemodialysis显示文摘 | Pia Thylén JL | 2000 | Nephrol Dial Transplant2000，15，： | 1 |
| 18 | A survey and comparison of peer-to-peer overlay network sehemes显示文摘 | LUA K CROWCROFT J PIAS M | 2005 | IEEE Corn munications Survey and Tutorial2005，7，2： | 1 |
| 19 | Crustacean haemocytes and haematopoiesis 显示文摘 | Mats W J Pia K | 2000 | Aquaculture2000，191，13： | 1 |
| 20 | A survey and comparison of peero-to-peer overlay network schemes显示文摘 | Lua K Crowcroft J pias M | 2005 | IEEE Communications Survey and Trutorial2005，7，2： | 1 |
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