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| 1 | p53 upregulated by HIF-la promotes hypoxiainduced G2/M arrest and renal fibrosis in vitro and in vivo显示文摘Hypoxia plays an important role in the genesis and progression of renal fibrosis.The underlying mechanisms, however, have not been sufficiently elucidated. We examined the role of p53 in hypoxia-induced renal fibrosis in cell culture (human and rat renal tubular epithelial cells) and a mouse unilateral ureteral obstruction (UUO) model. Cell cycle of tubular cells was determined by flow cytometry, and the expression of profibrogenic factors was determined by RT-PCR, immunohistochemistry, and western blotting. Chromatin immunoprecipitation and luciferase reporter experiments were performed to explore the effect of HIF-lα on p53 expression. We showed that, in hypoxic tubular cells, p53 upregulation suppressed the expression of CDK1 and cyclins Bl and DI, leading to cell cycle (G2/M) arrest (or delay) and higher expression of TGF-β, CTGF, collagens, and fibronectin. p53 suppression by siRNA or by a specific p53 inhibitor (PIF-α) triggered opposite effects preventing the G2/M arrest and profibrotic changes. In vivo experiments in the UUO model revealed similar antifibrotic results following intraperitoneal administration of PIF-α(2.2 mg/kg). Using gain-of-function, loss-of-function, and luciferase assays, we further identified an HRE3 region on the p53 promoter as the HIF-lα-binding site. The HIF-la-HRE3 binding resulted in a sharp transcriptional activation of p53. Collectively, we show the presence of a hypoxia-activated, p53-responsive profibrogenic pathway in the kidney. During hypoxia, p53 upregulation induced by HIF-la suppresses cell cycle progression, leading to the accumulation of G2/M cells, and activates profibrotic TGF-β and CTGF-mediated signaling pathways, causing extracellular matrix production and renal fibrosis. | Limin Liu Peng Zhang Ming Bai Lijie He Lei Zhang Ting Liu Zhen Yang Menglu Duan Minna Liu Baojian Liu Rui Du Qi Qian Shiren Sun | 2019 | Journal of Molecular Cell Biology2019，11，5： | 18 |
| 2 | MODELLING STRAIN-RATE-DEPENDENCY OF NATURAL SOFT CLAYS COMBINED WITH ANISOTROPY AND DESTRUCTURATION显示文摘The paper aims to investigate modelling the strain-rate-dependency of natural soft clays combined with anisotropy and destructuration using an elasto-viscoplastic model.The model is based on Perzyna's overstress theory and the elastoplastic model S-CLAY1S.Tests at constant strain-rate and creep tests under both one-dimensional and triaxial conditions on several clays are simulated.Simulations highlight the loading scenarios in which it is necessary to account for anisotropy and/or destructuration in order to get accurate predictions.Comparisons between the predicted and measured results demonstrate that the proposed model can successfully reproduce the time-dependent behaviour of natural soft clays under different loading conditions. | Zhen-Yu Yin Minna Karstunen | 2011 | Acta Mechanica Solida Sinica2011，24，3： | 12 |
| 3 | Effect of methamidophos on soil fungi community in microcosms by plate count,DGGE and clone library analysis显示文摘Methamidophos 广泛地被使用在北中国的杀虫剂。在黑色的真菌的社区玷污的土壤上的 methamidophos 的潜在的影响被板计数, 28S rDNA-PCR-DGGE,和克隆图书馆分析估计。三个 methamidophos 层次(50,150,和 250 mg/kg ) 在土壤缩影被测试。从板计数的结果在一个 60-d 缩影实验期间证明 methamidophos ( 250 mg/kg )的高集中能显著地刺激采指纹显示出的模式的真菌的 populations.DGGE (使中毒的坡度胶化电气泳动)在 methamidophos.Shannon 差异索引的压力下面的 culturable 和全部的真菌社区的回答之间的重要差别从 DGGE 计算了侧面显示在有 methamidophos 处理的所有缩影的 culturable 真菌在 1 星期孵化以后增加了。然而,全部的真菌的差异索引在第一个星期内减少了,作为与 culturable 真菌的刺激相比。然而,在第 8 星期, methamidophos 对待的所有缩影类似于在由香农建议差异为 culturable 和总数索引真菌的社区结构的控制缩影。相反,在 1 个星期以后, culturable 和 unculturable 的真菌的结构被聚类分析两个都在 methamidophos 的压力下面扰乱到不同程度。克隆定序分析显示了刺激病原并且 unculturable 由 methamidophos 处理的真菌的人口,植物病爆发的 suggetsing 潜力风险。 | LI Xinyu ZHANG Huiwen WU Minna ZHANG Yan ZHANG Chenggang | 2008 | Journal of Environmental Sciences2008，20，5： | 11 |
| 4 | Ultrasound-Guided Transmuscular Quadratus Lumbar Block Reduces Opioid Consumption after Laparoscopic Partial Nephrectomy显示文摘Objectives Transmuscular quadratus lumborum block(TQLB)may provide postoperative analgesia in patients undergoing intraperitoneal surgeries.The purpose of this study was to examine the potential efficacy of TQLB among patients undergoing retroperitoneal procedures,such as the laparoscopic partial nephrectomy(LPN).Methods This prospective,randomized,controlled study was conducted from August 2017 to November 2018 at Peking Union Medical College Hospital(Beijing,China).Patients who were scheduled for a LPN,aged 18・70 years old with an ASA physical status score of I-II were randomly assigned to receive either TQLB with 0.6 ml/kg of 0.5%ropivacaine plus general anesthesia(TQLB group)or general anesthesia alone(control group).Patient-controlled intravenous analgesia with morphine was initiated immediately upon surgery completion.The primary outcome was the cumulative consumption of morphine within 8 h after surgery.The secondary outcome included postoperative consump廿ons of morphine at other time points,pain score at rest and during activity,postoperative nausa and vomitting(PONV),and recovery related parameters.Results Totally 30 patients per group were recruited in the study.The 8 h consumption of morphine was lower in theTQLB group than in the control group(median,0.023 mg/kg vs.0.068 mg/kg,U=207.5,P<0.001).No significant differences were observed in postoperative pain scores between the two groups.Patients in the TQLB group had fewer episodes of PONV(20%vs.47%,χ2=4.&P=0.028)in the first 24 h after surgery and higher scores for quality of recovery(mean,13&6 vs.131.9,t=-2.164,P=0.035)120 h after surgery than the controls.Conclusions TQLB resulted in an opioid-sparing effect during the early postoperative period following LPN,as well as a lower incidence of PONV and improved quality of recovery. | Xulei Cui Xu Li Minna Li Yuelun Zhang Yi Xie Weigang Yan Yushi Zhang Zhigang Ji Yuguang Huang | 2020 | Chinese Medical Sciences Journal2020，35，4： | 10 |
| 5 | Diet and epigenetics in colon cancer显示文摘Over the past few years, evidence has accumulated indicating that apart from genetic alterations, epigenetic alterations, through e.g. aberrant promoter methylation, play a major role in the initiation and progression of colorectal cancer (CRC). Even in the hereditary colon cancer syndromes, in which the susceptibility is inherited dominantly, cancer develops only as the result of the progressive accumulation of genetic and epigenetic alterations. Diet can both prevent and induce colon carcinogenesis, for instance, through epigenetic changes, which regulate the homeostasis of the intestinal mucosa. Food-derived compounds are constantly present in the intestine and may shift cellular balance toward harmful outcomes, such as increased susceptibility to mutations. There is strong evidence that a major component of cancer risk may involve epigenetic changes in normal cells that increase the probability of cancer after genetic mutation. The recognition of epigenetic changes as a driving force in colorectal neoplasia would open new areas of research in disease epidemiology, risk assessment, and treatment, especially in mutation carriers who already have an inherited predisposition to cancer. | Minna Nystrm Marja Mutanen | 2009 | World Journal of Gastroenterology2009，15，3： | 8 |
| 6 | Impact of acetochlor on ammonia-oxidizing bacteria in microcosm soils显示文摘Acetochlor is an increasingly used herbicide on corn in North China. Currently, the effect of acetochlor on soil ammonia-oxidizing bacteria (AOB) communities is not well documented. Here, we studied the diversity and community composition of AOB in soil amended with three concentrations of acetochlor (50, 150, 250 mg/kg) and the control (0 mg acetochlor/kg soil) in a microcosm experiment by PCR-DGGE (polymerase chain reaction-denaturing gradient gel electrophoresis) and the phylogenetic analysis of excised DGGE bands. DGGE profiles showed that acetochlor had a stimulating effect on AOB at the early stage after acetochlor amended, and the order of intensity and duration is medium-acetochlor amended samples (AM) > low-acetochlor amended samples (AL) > high-acetochlor amended samples (AH). At the end of 60 d microcosm, acetochlor had a negative effect on the diversity of AOB. Cluster analysis of DGGE profiles showed that acetochlor had a greater effect on the community structure of AOB on day 60 than on day 1. The phylogenetic analysis revealed that all the sequences of excised DGGE bands were closely related to members of the genus Nitrosospira and formed two separate subclusters designated as subcluster 1 and subcluster 2 affiliated respectively with clusters 3 and 4 in Nitrosospira as defined by Stephen. Some dominant AOB had a change from subcluster 2 to subcluster 1 with the incubation. The results showed that acetochlor had an effect on the AOB on a long-term basis and the chronic effect of acetochlor should be paid more attention in future. | Xinyu LI Chenggang ZHANG | 2008 | Journal of Environmental Sciences2008，20，9： | 7 |
| 7 | Soil fungistasis and its relations to soil microbial composition and diversity:A case study of a series of soils with different fungistasis显示文摘Fungistasis is one of the important approaches to control soil-borne plant pathogens.Some hypotheses about the mechanisms for soil fungistasis had been established,which mainly focused on the soil bacterial community composition,structure,diversity as well as function.In this study,the bacterial community composition and diversity of a series of soils treated by autoclaving,which coming from the same original soil sample and showing gradient fungistasis to the target soil-borne pathogen fungi Fusarium gr... | Wu Minna Zhang Huiwen Ll Xinyu Zhang Yan Su Zhencheng Zhang Chenggang | 2008 | Journal of Environmental Sciences2008，20，7： | 7 |
| 8 | Encapsulating metal organic framework into hollow mesoporous carbon sphere as efficient oxygen bifunctional electrocatalyst显示文摘Applying metal organic frameworks(MOFs) in electrochemical systems is a currently emerging field owing to the rich metal nodes and highly specific surface area of MOFs. However, the problems for MOFs that need to be solved urgently are poor electrical conductivity and low ion transport. Here we present a facile in situ growth method for the rational synthesis of MOFs@hollow mesoporous carbon spheres(HMCS)yolk–shell-structured hybrid material for the first time. The size of the encapsulated Zeolitic Imidazolate Framework-67(ZIF-67) is well controlled to 100 nm due to the spatial confinement effect of HMCS, and the electrical conductivity of ZIF-67 is also increased significantly. The ZIF@HMCS-25% hybrid material obtained exhibits a highly efficient oxygen reduction reaction activity with 0.823 V(vs. reversible hydrogen electrode) half-wave potential and an even higher kinetic current density(JK= 13.8 m A cm-2) than commercial Pt/C. ZIF@HMCS-25% also displays excellent oxygen evolution reaction performance and the overpotential of ZIF@HMCS-25% at 10 m A cm-2 is 407 m V. In addition, ZIF@HMCS-25% is further employed as an air electrode for a rechargeable Zn–air battery, exhibiting a high power density(120.2 m W cm-2 at 171.4 m A cm-2) and long-term charge/discharge stability(80 h at 5 m A cm-2). This MOFs@HMCS yolk–shell design provides a versatile method for the application of MOFs as electrocatalysts directly. | Wanfeng Xiong Hongfang Li Hanhui You Minna Cao Rong Cao | 2020 | National Science Review2020，7，3： | 6 |
| 9 | Replacing PVP by macrocycle cucurbit[6]uril to cap sub-5 nm Pd nanocubes as highly active and durable catalyst for ethanol electrooxidation显示文摘Pd nano cubes(NCs)en closed by six{100}facets are fasci nating model materials for both fun dame ntal studies and practical applicati ons.However,the only available method to prepare well-defined sub-10 nm Pd NCs was developed by Xia et al.more than 10 years ago,un avoidably using polyvinyl pyrrol id one(PVP)polymer to preve nt particle aggregati on.The strongly adsorbed PVP extremely deteriorates the catalysts*efficiency because of the high coverage of accessible surface-active sites.Numerous efforts have been devoted to replacing PVP with weaker capping agents but with limited progress predominately due to the difficulties in tuning the growth kinetics of Pd NCs.For the first time,we report that macrocycle cucurbit[6]uril(CB[6])can replace PVP in the synthesis of Pd NCs by dedicatedly controlling the growth parameters.CB[6]capped Pd NCs showed 1.1-1.5 times in creased specific surface area compared to the surfactant-free commercial Pd catalysts.Moreover,X-ray photoelectron spectroscopy dem on strated the modified electronic structure of Pd NCs through the carb onyl group of CB[6].Consequently,compared to the commercial catalysts,the obtained Pd NCs exhibited 7 times higher current density towards ethanol oxidation reaction.Remarkably,after 17 h of continuous work,it reduced deactivation by up to 1-4 orders of magnitude. | Dongshuang Wu Minna Cao Rong Cao | 2019 | Nano Research2019，12，10： | 3 |
| 10 | Executionary pathway for apoptosis:lessons from mutant mice显示文摘Apoptosis or programmed cell death (PCD) is an evolutionarily conserved cellular process that is essential for normal development and homeostasis of multicellular organisms. Defects in the apoptosis signaling result in many diseases including autoimmune diseases and cancer. The apoptosis signaling pathway was first described genetically in the nematode Caenorhabditis elegans which serves as a framework for the more complex apoptotic pathways that exist in mammals. In this review, we will discuss the apoptotic pathways that are emerging in mammals as elucidated by studies of gene-targeted mutant mice. | WOO MINNA RAZQALLAH HAKEM TAK W.MAK | 2000 | Cell Research2000，10，4： | 3 |
| 11 | 纤维化性间质性肺疾病急性加重患者的预后及其死亡原因显示文摘背景本研究旨在比较具有急性加重(AE)史的特发性肺纤维化(IPF)和其他纤维化性间质性肺疾病(FILD)患者的临床特点、预后影响因素和死亡原因。方法回顾性收集因AE-IPF和AE-FILD而住院治疗的患者的临床资料。评价和比较IPF和非IPF患者的临床特点和生存资料。从死亡证明中获取患者潜在的和直接死亡原因。结果共128例患者符合入选标准。本组患者中,IPF(79例,62%)、类风湿关节炎相关间质性肺疾病(RA-ILD,17例,14%)和石棉肺(11例,8.6%)是最常见的FILD亚型。因AE-IPF住院的患者的中位存活时间为2.6个月,而其他AE-FILDs患者中位存活期为21个月(P<0.001)。住院时的年龄、性别或肺功能测试结果无法解释患者存活时间的差异。非特异性间质性肺炎和RA-ILD患者的预后最佳。肺纤维化是IPF患者和其他FILD患者的最常见潜在死亡原因,分别占其死亡原因的87%和78%。结论我们发现,具有AE史的非IPF患者的存活时间明显长于AE-IPFs患者。患者的预后受肺潜在疾病的影响,这是因为肺纤维化是大部分所有经历AE的FILD患者的潜在死亡原因。 | Johanna Salonen Minna Purokivi Risto Bloigu Riitta Kaarteenaho 霍永丰(译者) | 2020 | 英国医学杂志中文版2020，23，6： | 2 |
| 12 | Laparoscopic Distal Pancreatectomy Offers Shorter Hospital Stays with Fewer Complications显示文摘 | Joseph DiNorcia Beth A. Schrope Minna K. Lee Patrick L. Reavey Sarah J. Rosen James A. Lee John A. Chabot John D. Allendorf | 2010 | Journal of Gastrointestinal Surgery2010，，11： | 2 |
| 13 | Threat of heavy metal pollution in halophytic and mangrove plants of Tamil Nadu, India显示文摘 | Govindasamy Agoramoorthy Fu-An Chen Minna J. Hsu | 2007 | Environmental Pollution2007，，2： | 2 |
| 14 | Trastuzumab-DM1 is highly effective in preclinical models of HER2-positive gastric cancer显示文摘 | Mark Barok Minna Tanner Katri K?ninki Jorma Isola | 2011 | Cancer Letters2011，，2： | 2 |
| 15 | The Discursive Practice of Participation in an Elementary Classroom Community 显示文摘 | Minna Kovalainen & Kristiina Kumpulainen | 2005 | InStructional Science2005，33，3： | 1 |
| 16 | Fragile histidine triad(FHIT)gene abnormalities in lung cancer显示文摘 | Zochbauer-Muller S Wistuba II Minna JD | 2000 | Clin Lung Cancer2000，2，2： | 1 |
| 17 | The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation显示文摘 | SHIVAKUMAR L MINNA J SAKAMAKI T | 2002 | Mol Cell Biol2002，22，12： | 1 |
| 18 | The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation显示文摘 | Shivakumar L Minna J Sakamaki T | 2002 | Mol Cell Biol2002，22，12： | 1 |
| 19 | PREVENTION OF SYSTEMIC HYPERLACTATEMIA DURING SPLANCHNIC ISCHEMIA显示文摘 | Stephan M. Jakob Minna Merasto-Minkkinen Jyrki J. Tenhunen Antero Heino Esko Alhava Jukka Takala | 2000 | Shock2000，，2： | 1 |
| 20 | The rassfla tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation显示文摘 | Shivakumar L Minna J Sakamaki T | 2002 | Mol Cell Biol2002，22，12： | 1 |
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