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| 1 | Current Status of Conventional and Molecular Interventions for Blast Resistance in Rice显示文摘Pyricularia oryzae anamorph of Magnaporthe oryzae is one of the most notorious fungal pathogens causing severe economic loss in rice production worldwide. Various methods, viz. cultural, biological and molecular approaches, are utilized to counteract this pathogen. Moreover, some tolerant or resistant rice varieties have been developed with the help of breeding programmes. Isolation and molecular characterization of different blast resistance genes now open the gate for new possibilities to elucidate the actual allelic variants of these genes via various molecular breeding and transgenic approaches. However, the behavioral pattern of this fungus breakups the resistance barriers in the resistant or tolerant rice varieties. This host-pathogen barrier will be possibly countered in future research by comparative genomics data from available genome sequence data of rice and M. oryzae for durable resistance. Present review emphasized fascinating recent updates, new molecular breeding approaches, transgenic and genomics approaches(i.e. mi RNA and genome editing) for the management of blast disease in rice. The updated information will be helpful for the durable, resistance breeding programme in rice against blast pathogen. | Deepti SRIVASTAVA Md SHAMIM Mahesh KUMAR Anurag MISHRA Pramila PANDEY Deepak KUMAR Prashant YADAV Mohammed Harrish SIDDIQUI Kapildeo Narayan SINGH | 2017 | Rice science2017，24，6： | 8 |
| 2 | Sitagliptin,sitagliptin and metformin,or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats显示文摘Diabetic neuropathies are a family of nerve disorders caused by diabetes.Symptoms of the disease include nerve palsy,mononeuropathy,mononeuropathy multiplex,diabetic amyotrophy,painful polyneuropathy,autonomic neuropathy,and thoracoabdominal neuropathy.In this study,type 2 diabetes in rats was induced with nicotinamidestreptozotocin.Drug treatment was initiated on the d 15,with the combination regimen of metformin,pioglitazone and glimipiride or metformin and sitagliptin or sitagliptin,amitriptyline and sitagliptin and led to significantly improved glycemic control,increased grip strength and paw jumping response on d 21,28 and 35(P < 0.001).Significant increases in blood protein levels and decreases in urinary protein levels were observed in the animals treated with the different regimens on d 21,28 and 35(P < 0.001).Combined treatment of streptozotocin and nicotinamide caused marked degeneration of nerve cells,while administration of metformin and sitagliptin showed tissue regeneration and no body weight gain.In conclusion,treatment with sitagliptin and sitagliptin combined with metformin or amitriptyline results in no body weight gain,but causes an increase in grip strength and pain sensitivity,exhibits neural protection,and reverses the alteration of biochemical parameters in rats with streptozotocin-nicotinamide induced type 2 diabetes. | Ashish Kumar Sharma Akash Sharma Rita Kumari Kunal Kishore Divya Sharma Bharthu Parthsarthi Srinivasan Ashok Sharma Santosh Kumar Singh Samir Gaur Vijay Singh Jatav Prashant Sharma Varnika Srivastava Sneha Joshi Megha Joshi Prashant Kumar Dhakad Davender Singh Kanawat Akanksha Mishra Anil Sharma Dharmendra Singh Ravinder Pal Singh Himmat Singh Chawda Rambir Singh Sachin Kumar Raikwar Muneem Kumar Kurmi Pankaj Khatri Ashutosh Agarwal Arshee Munajjam | 2012 | The Journal of Biomedical Research2012，26，3： | 2 |
| 3 | 基于RAPD-PCR标记的印度亚麻品种遗传多样性和指纹图谱分析(英文)显示文摘栽培的亚麻(L.usitatissimum)通常为亚麻籽,以其油分和纤维而被认为是具有较高经济价值的作物之一。开发亚麻遗传资源并进一步进行遗传改良,须了解其遗传变异的范围和结构。位于坎普尔的C.S.农业科技大学种质管理单位保存有广泛收集而来的2772份栽培和野生亚麻资源。从中选出23份不同基因型栽培亚麻品种包括5份两用品种、4份种用品种、14份具有不同形态和经济特性的引进种用品种以及1份野生品系(L.grandiflorum),采用RAPD标记进行遗传多样性分析。20条随机引物共产生242条带,每条引物扩增带数为1~20条,平均为10.95条。所有基因型和位点的RAPD多态性比例为90.49%。DICE系数相似矩阵分析揭示其遗传相似性为0.63~0.97,平均相似系数为82%,说明这些亚麻品种(系)的遗传背景较窄。采用UPGMA法以及NTSYS-pc软件的SAHN聚类分析模型对遗传相似矩阵进行聚类分析,发现属于L.uitatisimums的所有栽培品种在X轴上可聚为一类,而L.grandiflorum野生种单独在Y轴上聚为一类。主成分分析结果表明,除了Shekha(r优良种用品种)和野生种L.grandiflorum广泛分布外,其他所有种用品种、两用品种和外来品种聚类很近。由于亚麻栽培品种的遗传关系相近,须对亚麻种质的各种基因型进行鉴定,以拓宽今后育种计划中的遗传基础。 | Prashant Shekhar Gupta Sangeeta Srivastava Manoj Kumar Srivastava Abhilash Gupta | 2010 | 广西农业科学2010，41，3： | 2 |
| 4 | Organizational identification among global virtual team members: The role of individualism-collectivism and uncertainty avoidance显示文摘 | Debmalya Mukherjee Susan C. Hanlon Ben L. Kedia Prashant Srivastava | 2012 | Cross Cultural Management: An International Journal2012，，4： | 1 |
| 5 | Mathematical model for smoking: Effect of determination and education显示文摘 | Anuradha Yadav Prashant K. Srivastava Anuj Kumar | 2015 | International Journal of Biomathematics2015，8，1： | 1 |
| 6 | Comparison between intranasal dexmedetomidine and intranasal ketamine as premedication for procedural sedation in children undergoing MRI: a double-blind, randomized, placebo-controlled trial显示文摘 | Prakhar Gyanesh Rudrashish Haldar Divya Srivastava Prashant Mohan Agrawal Akhilesh Kumar Tiwari P. K. Singh | 2014 | Journal of Anesthesia2014，，1： | 1 |
| 7 | Reactor design issues for synthesis-gas fermentations 显示文摘 | MARSHALL D BREDWELL PRASHANT SRIVASTAVA R MARK WORDEN | 1999 | Biotechnology Progress1999，15，5： | 1 |
| 8 | Melasma: Treatment strategy显示文摘 | Virendra N. Sehgal Prashant Verma Govind Srivastava Ashok K. Aggarwal Sangeeta Verma | 2011 | Journal of Cosmetic and Laser Therapy2011，，6： | 1 |
| 9 | Melasma: Treatment strategy显示文摘 | Virendra N. Sehgal Prashant Verma Govind Srivastava Ashok K. Aggarwal Sangeeta Verma | 2011 | Journal of Cosmetic and Laser Therapy2011，，6： | 1 |
| 10 | Appraisal of land use/land cover of mangrove forest ecosystem using support vector machine显示文摘 | Sudhir Kumar Singh Prashant Srivastava Manika Gupta etc | 2014 | Environmental Earth Sciences2014，，5： | 1 |
| 11 | Application of modified atmosphere packaging using silicone membrane system for shelf life extension of pomegranate (Punica granatum L.) and its effect on physico-chemical properties显示文摘Objectives:The study was conducted to prolong the shelf life of freshly harvested pomegranate fruits and to find out its physiochemical properties during storage.Materials and Methods:Pomegranate fruits of variety‘Bhagawa’were stored in 200,300 gauge high-density polyethylene(HDPE)package,and silicone membrane modified atmospheric storage system at ambient conditions and 10℃.Gas composition inside the package,texture,color,and overall quality parameters were evaluated at these two storage temperatures.The physico-chemical properties such as total soluble solids,titratable acidity,ascorbic acid content,total,reducing,and non-reducing sugars,and physiological loss in weight(PLW)were also determined.Results:In ambient storage,the shelf life of pomegranate fruit was 10 days,whereas in modified atmosphere packaging(200 gauge HDPE,300 gauge HDPE,and silicone membrane system),the shelf life of pomegranate fruits was extended up to 60,60,25 days at ambient and 96,96,65 days at 10℃temperature,respectively.Conclusions:Among the 200,300 gauge HDPE package,and silicone membrane system treatments T1,T5,and T8,respectively,were found better with respect to all the sensory and quality parameters studied. | Shubhangi Srivastava Prashant Said | 2019 | Food Quality and Safety2019，3，3： | 0 |
| 12 | Delayed information induces oscillations in a dynamical model for infectious disease显示文摘During disease outbreak,it has been observed that information about the disease prevalence induces the individuafs behavioral changes.This information is usually assumed to be generated by the density of infective individuals and active mass media.The delay in reporting of these infective individuals may have its impact on generated information.Hence,to study the impact of delay on information generation,and therefore on the disease dynamics,a delay differential equation model is proposed and analyzed.The dynamics of information with delay effect is also modeled by a separate rate equation.Model analysis is performed and a unique infected equilibrium is obtained when the basic reproduction number(R0)is greater than one,whereas the disease free equilibrium always exists.When R0<1,the disease free equilibrium is found to be locally stable independent of delay effect.The unique infected equilibrium is found to be locally stable till delay reaches a threshold value.The global stability of the unique infected equilibrium is also established under some parametric conditions by constructing a suitable Lyapunov function.The occurrence of Hopf bifurcation is observed when the delay in information crosses the threshold value.Analytically,the direction and stability of bifurcating periodic solutions is established.Further,we observed the occurrence of Hopf-Hopf bifurcation at two different delays.At first delay threshold,the endemic equilibrium loses its st ability and produces periodic oscillations via Hopf bifurcation.It further regains its stability at second delay threshold via another Hopf bifurcation.Hence,the delay effect on information shows possibility of stability switches.Numerical experiments are carried out to support the obtained analytical results.Our study infers that the disease will show persistent oscillations if there is a significant time lag in reporting of infective after the disease outbreak.Thus,the delay in dissemination of information shows rich and complex dynamics in the model and provides important insights.We also observe numerically that the saturation in information plays a significant role on stability of infected equilibrium in presence of delay. | Anuj Kumar Prashant K Srivastava Anuradha Yadav | 2019 | International Journal of Biomathematics2019，12，2： | 0 |
| 13 | A review on re-emerging bacteriophage therapy in the era of XDR显示文摘In the present medicine world antibiotic resistance is one of the key threats to universal health coverage.Researchers continue to work hard to combat this global health concern.Phage therapy,an age-old practice during the early twentieth century,was outshined by the discovery of antibiotics.With the advent of widespread antibiotic resistance,phage therapy has again redeemed itself as a potential alternative owing to its adeptness to target bacteria precisely.Limited side effects,the ability to migrate to different body organs,a distinct mode of action,and proliferation at the infection site,make phages a profitable candidate to replace conventional antibiotics.The progressive outcome of numerous in vitro studies and case reports has validated the clinical efficacy of phage therapy.The bright perspective of using phages to treat bacterial infections has fueled enormous medical research to exploit their potential as therapeutics.The gaps in the information about phages and the lack of consent for clinical trials is major hurdle for consideration of phage therapy.Crafting phage therapy as a reality in medicine requires a coordinated effort from different fraternities.With this review,we aim to emphasize the importance of phage therapy in modern medicine.This review explains their historical journey,basic phage biology,cross-talk with the host immunity,obstacles with phage therapy,and their possible remedies.Comprehensive data on the various significant clinical trials of phage therapy has been presented.We evaluated the efficacy of antibiotics and phage therapy in part and in combination,along with recent progress and future perspectives of phage therapy. | POOJA BHADORIYA RICHA SHARMA REKHA MEHROTRA SIMRAN KAUR ISHA SRIVASTAVA MUKUL JAIN PRASHANT KAUSHIK | 2023 | BIOCELL2023，47，9： | 0 |
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