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| 1 | Epithelial-mesenchymal transition transcription factors and mi RNAs: “Plastic surgeons” of breast cancer显示文摘Growing evidence suggests that breast cancer cell plasticity arises due to a partial reactivation of epithelialmesenchymal transition(EMT) programs in order to give cells pluripotency, leading to a stemness-like phenotype. A complete EMT would be a dead end program that would render cells unable to fully metastasize to distant organs. Evoking the EMT-mesenchymal-toepithelial transition(MET) cascade promotes successful colonization of distal target tissues. It is unlikely that direct reprogramming or trans-differentiation without passing through a pluripotent stage would be thepreferred mechanism during tumor progression. This review focuses on key EMT transcriptional regulators, EMT-transcription factors involved in EMT(TFs) and the mi RNA pathway, which are deregulated in breast cancer, and discusses their implications in cancer cell plasticity. Cross-regulation between EMT-TFs and mi RNAs, where mi RNAs act as co-repressors or co-activators, appears to be a pivotal mechanism for breast cancer cells to acquire a stem cell-like state, which is implicated both in breast metastases and tumor recurrence. As a master regulator of mi RNA biogenesis, the ribonuclease type Ⅲ endonuclease Dicer plays a central role in EMTTFs/mi RNAs regulating networks. All these EMT-MET key regulators represent valuable new prognostic and predictive markers for breast cancer as well as promising new targets for drug-resistant breast cancers. | Caroline Moyret-Lalle Emmanuelle Ruiz Alain Puisieux | 2014 | World Journal of Clinical Oncology2014，5，3： | 7 |
| 2 | Variants in the Netrin-1 Receptor UNC5C Prevent Apoptosis and Increase Risk of Familial Colorectal Cancer显示文摘 | Marie–May Coissieux Jerneja Tomsic Marie Castets Heather Hampel Sari Tuupanen Nadine Andrieu Ilene Comeras Youenn Drouet Christine Lasset Sandya Liyanarachchi Laetitia Mazelin Alain Puisieux Jean–Christophe Saurin Jean–Yves Scoazec Qing Wang Lauri Aaltone | 2012 | Gastroenterology2012，，6： | 2 |
| 3 | Development of a new collidal drug carrier from chemicallymodified cyclodextrins :nanospheres, and influence ofphysicochemical and technological factors on particle size显示文摘 | Skiba M Duchene D Puisieux F | 1996 | Int J Pharm1996，129，： | 1 |
| 4 | Nanocapsule formation by interfacial deposition following solvent displacement显示文摘 | Fessi H Puisieux F Devissageut JP | 1989 | Int J Pharm1989，55，： | 1 |
| 5 | Insulin in W/O/W multiple emulsions:biological activity after oral administration in normal and diabetic rats显示文摘 | Cunha A S Grossiord J L Puisieux F | 1997 | J Microencapsulation1997，14，3： | 1 |
| 6 | Cancer cells escape from failsafe programs in a simple Twist显示文摘 | Puisieux A Valsesia-Wittmann S | 2006 | Bull Cancer2006，93，3： | 1 |
| 7 | Differential role of nitric oxide pathway and heat shock protein in preconditioning and lipopolysaccharide-induced brain ischemic tolerance显示文摘 | Puisieux F Deplanque D Pu Q | 2000 | Eur J Pharmacol2000，389，1： | 1 |
| 8 | Spontaneous formation of drug-containing amphiphilie β-cyelodextrin nanoeapsules 显示文摘 | Skiba M Nemati F Puisieux F | 1996 | Int J Pharm1996，145，： | 1 |
| 9 | Metastasis: a question of life or death 显示文摘 | Mehlen P Puisieux A | 2006 | NatRev Cancer2006，6，6： | 1 |
| 10 | Retinoblastoma and p53 tumor suppressor genes in human hepatoma cell lines 显示文摘 | Puisieux A Galvin K Troalen F | 1993 | FASEB J1993，7，14： | 1 |
| 11 | Annexin Ⅱ up-regulates cellular levels of p11 protein by a post-translational mechanisms显示文摘 | Puisieux A Ji J Ozturk M | 1996 | Biochem J1996，313，： | 1 |
| 12 | Cancer stem cells:the emerging challenge of drug targeting显示文摘 | Besancon R Valsesia-Wittmann S Puisieux A | | 0，，04： | 1 |
| 13 | Nanocapsules formation by interfacial polymer deposition following sol- vent displacement 显示文摘 | Fessi H Puisieux F Devissaguet J P | 1989 | Int J Pharm1989，55，1： | 1 |
| 14 | A Twist for survival and cancer progression显示文摘 | Puisieux A Valsesia-Wittmann S Ansieau S | 2006 | Br J Cancer2006，1694，1： | 1 |
| 15 | Antimetastatic activity of mdp-l-alanyl-cholesterol incorporated into various types of nanocapsules 显示文摘 | Barratt G Puisieux F Yu WP | 1994 | Int J Immunopharmacol1994，16，56： | 1 |
| 16 | Mechanisms of BTG2 activity, a transcriptional target of p53: evidences and hypothesis 显示文摘 | Puisieux A Magaud JP | 1999 | Bull Cancer1999，86，4： | 1 |
| 17 | Oligoclonality of tumorinfiltrating lymphocytes from human melanomas显示文摘 | Puisieux I Even J Pannetier C | 1994 | J Immunol1994，153，6： | 1 |
| 18 | Ambulatory blood pressure monitoring and postprandial hypotension in elderly persons with falls or syncopes显示文摘 | Puisieux F Bulckaen H Fauchais AL | 2000 | J Gerontol A Biol Sci Med Sci2000，55，9： | 1 |
| 19 | Antimetastatic activity of MOP-L-alanyl cholesterol incorporated into various types of nanocapsules显示文摘 | Barratt G Puisieux F Yu W P | 1994 | Int J Immunopharmacol1994，16，： | 1 |
| 20 | Nanocapsule formation by interfacial polymer deposition following solvent displacement 显示文摘 | Fessi H Puisieux F Devissaguet JP | 1989 | Int J Pharm1989，，： | 1 |
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