|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Potential of soluble CD26 as a serum marker for colorectal cancer detection显示文摘Colorectal cancer is characterized by a low survival rate even though the basis for colon cancer development,which involves the evolution of adenomas to carcinoma,is known.Moreover,the mortality rates continue to rise in economically transitioning countries although there is the opportunity to intervene in the natural history of the adenoma–cancer sequence through risk factors,screening,and treatment.Screening in particular accounted for most of the decline in colorectal cancer mortality achieved in the USA during the period 1975-2000.Patients show a better prognosis when the neoplasm is diagnosed early.Among the variety of screening strategies,the methods range from invasive and costly procedures such as colonoscopy to more low-cost and non-invasive tests such as the fecal occult blood test(guaiac and immunochemical).As a non-invasive biological serum marker would be of great benefit because of the performance of the test,several biomarkers,including cytologic assays,DNA and mRNA,and soluble proteins,have been studied.We found that the soluble CD26(sCD26)concentration is diminished in serum of colorectal cancer patients compared to healthy donors,suggesting the potential utility of a sCD26 immunochemical detection test for early diagnosis.sCD26 originates from plasma membrane CD26 lacking its transmembrane and cytoplasmic domains.Some 90%–95%of sCD26 has been associated with serum dipeptidyl peptidase IV(DPPIV)activity.DPP-IV,assigned to the CD26 cluster,is a pleiotropic enzyme expressed mainly on epithelial cells and lymphocytes.Our studies intended to validate this test for population screening to detect colorectal cancer and advanced adenomas are reviewed here. | Oscar J Cordero Monica Imbernon Loretta De Chiara Vicenta S Martinez-Zorzano Daniel Ayude Maria Paez de la Cadena F Javier Rodriguez-Berrocal | 2011 | World Journal of Clinical Oncology2011，2，6： | 5 |
| 2 | Comparative bioaccumulation of tracemetal in Penaeussty cirostrisine stuarine and wastal environments 显示文摘 | Paez O F Ruiz F C | 1995 | Estuarine Coastal and Shelf Sciende1995，40，1： | 1 |
| 3 | Production of structured triglycerides rich in n-3 polyunsaturated fatty acids by the aeidolysis of cod liver oil and caprylic acid in a packed-bed reactor: equilibrium and kinetics 显示文摘 | Camacho Paez B Robles Medina A Camacho Rubio F | 2002 | Chemical Engineering Science2002，57，8： | 1 |
| 4 | Factors associated with mortality in patients with bloodstream infection and pneumonia due to Stenotrophomonas maltophilia显示文摘 | PAEZ J I G TENGAN F M BARONE A A | 2008 | Eur J Clin Microbiol2008，27，10： | 1 |
| 5 | Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia显示文摘 | PAEZ J G DAVID F S | 2004 | Cancer Res2004，64，： | 1 |
| 6 | Role of nitric oxide in ischemia/reperfusion of the rat kidney显示文摘 | Lopez-Neblina F Paez AJ Toledo AH | 1994 | Circ Shock1994，44，2： | 1 |
| 7 | Dopamine D2 and D4 receptor genes distinguish the clinical presence of tics in obsessivecompulsive disorder显示文摘 | Nicolini H Cruz C Paez F Camarena B | 1998 | Gac Med Mex1998，134，5： | 1 |
| 8 | Dopamine D2 and D4 receptor genes distinguish the clinical presence of tics in obsessive-compulsive disorder显示文摘 | Nicolini H Cruz C Paez F | 1998 | Gac Med Mex1998，134，： | 1 |
| 9 | Seasonal variation in water quality and chlorophyll a of semi-intensive shrimp ponds in a subtropical environment显示文摘 | GUERRERO S R PAEZ O F RUIZ A C | 1998 | Hydrobiologia1998，391，13： | 1 |
| 10 | Clinical aspects and prognostic factors in elderly patients hospitalized for community-acquired pneumonia显示文摘 | Garcia-Ordonez MA GarciaoJimene JM Paez F | 2001 | Eur J Clinic Microbid Infect Dis2001，20，： | 1 |
| 11 | Differential effect of estradiol on antibody secretion of murine hybridomas 显示文摘 | Molina J Masso F Paez A | 1999 | Hybridoma1999，18，4： | 1 |
| 12 | High levels of matrix metalloproteinases regulate proliferation and hormone secretion in pituitary cells 显示文摘 | Paez Pereda M Ledda M F Goldberg V | 2000 | J Clin Endocrinol Metab2000，85，1： | 1 |
| 13 | Activating mutations of the noonan syndrome-associat- ed SHP2/PTPN11 gene in human solid tumors and a-dult acute myelogenous leukemia显示文摘 | BENTIRES-ALJ M PAEZ J G DAVID F S | 2004 | Cancer Res2004，64，： | 1 |
| 14 | Evaluation of In-vehicle Dynamic Speed Assistance in Spain: Algorithm and Driver Behavior 显示文摘 | F Jimenez F Aparicio J Paez | 2008 | The Institution of Engineering and Technology2008，，2： | 1 |
| 15 | Personalized health care system with virtual reality rehabilitation and appro- priate information for seniors 显示文摘 | Gachet Paez D Aparicio F de Buenaga M | 2012 | Sensors2012，12，5： | 1 |
| 16 | Role of nitric oxide in ischemia/reperfusion of the rat kidney显示文摘 | LOPEZ-NEBLINA F PAEZ A J TOLEDO A H | 1994 | Circ Shock1994，44，2： | 1 |
| 17 | Fundamental concepts of the Boot- strap for statistical analysis of mechanical systems 显示文摘 | Paez T L Hunter N F | 1998 | Ex- perimental Techniques1998，22，3： | 1 |
| 18 | Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia显示文摘 | Bentires-Alj M Paez J G David F S | 2004 | Cancer Res2004，64，24： | 1 |
| 19 | Modeling the effect of free water on enzyme activity in immobilized lipase-catalyzed reactions in organic solvents显示文摘 | Paez B C Medina A R Rubio F C | 2003 | Enzyme and Microbial Technology2003，33，： | 1 |
| 20 | Trace metals in the Mexican shrimp Penaeus vannamei from estuarine and marine environments 显示文摘 | PAEZ O F RUIZ F C | 1995 | Environmental Pollution1995，87，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员