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| 1 | 二甲双胍与吡格列酮两种2型糖尿病药物在亲水作用色谱上的保留机理研究(英文)显示文摘二甲双胍和吡格列酮是治疗2型糖尿病的常见药物,经常用于同一复方制剂。制药和临床领域常要求同时测定这两种药物。亲水作用色谱近来在医药分析领域展现出良好的前景。本文通过研究流动相的有机溶剂含量、pH值和缓冲盐浓度等参数对色谱保留的影响,从而尝试揭示两种药物在亲水性硅胶柱上的分离机理。流动相中甲醇的增加会导致二甲双胍的保留因子的增加。流动相pH值比较低时,二甲双胍的保留因子会随着pH值升高而增加,而当pH值>6.09,其反而会随着pH值的升高而下降。吡格列酮的保留因子几乎不受甲醇比例和pH值的影响。缓冲盐浓度对两种药物的保留因子几乎都没有影响。因此,对于二甲双胍,亲水作用是主要的保留机理,静电作用和氢键也起到了重要作用。对于吡格列酮,亲水作用是支配性的。经过优化的亲水作用色谱方法可成功地应用到分离测定两种药物在2型糖尿病复方药物中的含量。 | 鲁肖飞 Caroline Martin 戚忠林 Pari Samani Zemen Berhe Dominic B Siaw Shyam K Pahari 左跃钢 | 2019 | 分析科学学报2019，35，6： | 4 |
| 2 | Modeling and analysis of a prey- predator system with stage-structure and harvesting 显示文摘 | Kar T K Pahari U K | 2007 | Nonlinear Anal RWA2007，8，2： | 1 |
| 3 | The Effective Source Rocks in the Cambay Basin,India显示文摘 | Banerjee A Pahari S Jha M | 2002 | AAPG Bulletin2002，86，3： | 1 |
| 4 | The effective source rocks in the Cambay Basin,India显示文摘 | Banerjee A Pahari S Jha M | 2002 | AAPG Bulletin2002，86，3： | 1 |
| 5 | A comparative study of paediatric oral premedication:midazolam,ketamine and low dose combination of midazolam and ketamine显示文摘 | Banerjee B Bose A Pahari S | | 0，，： | 1 |
| 6 | Non-selective harvesting in prey-predator models with delay显示文摘 | Kar K T Pahari J K | 2006 | Communications in Nonlinear Science and Numerical Simulation2006，11，： | 1 |
| 7 | Ground and excited state proton transfer and antioxidant activity of 7-hydroxyflavone in model membranes: Absorption and fluorescence spectroscopic studies显示文摘 | CHAUDHURI S PAHARI B SENGUPTA P K | 2009 | Biophys Chem2009，139，： | 1 |
| 8 | Modeling and analysis of a prey-predator system with stage-structure and harvest- ing显示文摘 | Kar T K Pahari U K | 2007 | Nonlinear Analysis2007，2，8： | 1 |
| 9 | The effective source rocks in the Cambay Basin, India显示文摘 | BANERJEE A PAHARI S JHA M | 2002 | AAPG Bulletin2002，86，： | 1 |
| 10 | Outcome of severe steroid-dependent nephrotic syndrome treated with mycophenolate mofetil显示文摘 | Banerjee S Pahari A Sengupta J | 2013 | Pediatr Nephrol2013，28，1： | 1 |
| 11 | Outcome of sepsis- associated acute kidney injury in an intensive care unit: an experience from a tertiary care center of central Nepali显示文摘 | Ghimire M Pahari B Sharma SK | 2014 | Saudi J Kidney Dis Transpl2014，25，4： | 1 |
| 12 | The effective source reeks in the Cambay Basin,India显示文摘 | Banerjee A Pahari S Jha M | 2002 | AAPG Bulletin2002，86，3： | 1 |
| 13 | Modelling and analysis of a prey-predator system with stage-structure and harvesting显示文摘 | Kar T K Pahari U K | 2007 | Real World Applicatons2007，，8： | 1 |
| 14 | Modelling and analysis of a prey–predator system with stage-structure and harvesting显示文摘 | T.K. Kar U.K. Pahari | 2006 | Nonlinear Analysis: Real World Applications2006，，2： | 1 |
| 15 | The venom gland transcriptome of the Desert Massasauga rattlesnake ( Sistrurus catenatus edwardsii ) : towards an understanding of venom composition among advanced snakes (Superfamily Colubroidea)显示文摘 | Pahari S Mackessy S P Kini R M | 2007 | BMC Mol Biol2007，8，： | 1 |
| 16 | Spectroscopic studies on calcium depleted horseradish peroxidase:observation of tryptophan sensitized bound terbium (Ⅲ) fluorescence显示文摘 | Pahari D Patel A B Behere D V | 1995 | J Inorg Biochem1995，60，： | 1 |
| 17 | Non - selective harves- ting in prey - predator models with delay显示文摘 | T K KAR U K PAHARI | 2006 | Communi- cations in Nonlinear Science and Numerical Simulation2006，11，4： | 1 |
| 18 | Anovel approach for intestinal elongation using acellular dermal matrix:An experimental study in rats显示文摘 | Pahari MP Raman A Bloomenthal A | 2006 | Transplant Proc2006，38，6： | 1 |
| 19 | A novel approach for intestinal elongation using acellular dermal matrix : an experimental study in rats显示文摘 | Pahari MP Raman A Bloomenthal A | 2006 | Transplant Proc2006，38，6： | 1 |
| 20 | Investigating Mithramycin deoxysugar biosynthesis: enzymatic total synthesis of TDP-D -olivosc 显示文摘 | WANG G KHAREL MK PAHARI P | 2011 | Chembiochem2011，12，17： | 1 |
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