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| 1 | Monocyte chemoattractant protein-1, transforming growth factor-β1, nerve growth factor, resistin and hyaluronic acid as serum markers:comparison between recurrent acute and chronic pancreatitis显示文摘BACKGROUND: Diagnostic parameters that can predict the presence of chronic pancreatitis(CP) in patients with recurrent pain due to pancreatitis would help to direct appropriate therapy. This study aimed to compare the serum levels of monocyte chemoattractant protein-1(MCP-1), transforming growth factor-β1(TGF-β1), nerve growth factor(NGF), resistin and hyaluronic acid(HA) in patients with recurrent acute pancreatitis(RAP) and CP to assess their ability to differentiate the two conditions.METHODS: Levels of serum markers assessed by enzymelinked immunosorbent assay(ELISA) were prospectively compared in consecutive patients with RAP, CP and in controls and stepwise discriminant analysis was performed to identify the markers differentiating RAP from CP.RESULTS: One hundred and thirteen consecutive patients(RAP=32, CP=81) and 78 healthy controls were prospectively enrolled. The mean(SD) age of the patients was 32.0(14.0)years; 89(78.8%) were male. All markers were significantly higher in CP patients than in the controls(P<0.001); MCP-1NGF and HA were significantly higher in RAP patients than in the controls(P<0.001). Stepwise discriminant analysis showed significant difference(P=0.002) between RAP and CP for resistin with an accuracy of 61.9%, discriminant scores of ≤-0.479 and ≥0.189 indicating RAP and CP, respectively. The other markers had no differential value between RAP and CP.CONCLUSION: Serum resistin is a promising marker to differentiate between RAP and CP and needs validation in future studies, especially in those with early CP. | M Ganesh Kamath C Ganesh Pai Asha Kamath Annamma Kurien | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，2： | 7 |
| 2 | Continuing episodes of pain in recurrent acute pancreatitis: Prospective follow up on a standardised protocol with drugs and pancreatic endotherapy显示文摘AIM To assess the outcomes of drug therapy(DT)followed by pancreatic endotherapy for continuing painful episodes in recurrent acute pancreatitis.METHODS DT comprised of pancreatic enzymes and antioxidants failing which,endotherapy(ET;pancreatic sphincterotomy and stent placement)was done.The frequency of pain,its visual analogue score(VAS),quality of life(Qo L),serum C peptide and faecal elastase were compared between baseline and after 1 year of follow up in all patients and in the two subgroups on DT and ET.Response was defined as at least 50%reduction in the severity of pain to below a score of 5.RESULTS Of the thirty nine patients analysed,21(53.9%)responded to DT and 18(46.1%)underwent ET.The VAS for pain(7.0±2.0 vs 1.3±2.5,P<0.001)and the number of days with pain per month decreased[1.0(1.0,2.0)vs 1.0(0.0,1.0),P<0.001],and the Qo L scores[55.0(44.0,66.0)vs 38.0(32.00,51.00),P<0.01]improved significantly during follow up.Similar significant improvements were seen in patients in the subgroups of DT and ET except for Qo L in ET.The serum C-peptide(P=0.001)and FE(P<0.001)levels improved significantly in the entire group and in the two subgroups of patients except for the C peptide levels in patients on DT.CONCLUSION A standardised protocol of DT,followed by ET decreased the intensity and frequency of pain in recurrent acute pancreatitis,enhanced Qo L and improved pancreatic function. | C Ganesh Pai M Ganesh Kamath Mamatha V Shetty Annamma Kurien | 2017 | World Journal of Gastroenterology2017，23，19： | 2 |
| 3 | Improving hierarchical cluster analysis: a new method with outlier detection and automatic clustering显示文摘 | ALMEIDA J A S BARBOSA L M S PAIS A A C C | 2007 | Chemometrics and Intelligent Labora- tory Systems2007，87，2： | 1 |
| 4 | Surface roughness and its effects on the heat transfer mechanism in spray cooling 显示文摘 | Pais M R Chow L C Mathefdey E T | 1992 | ASME Journal of Heat Transfer1992，114，1： | 1 |
| 5 | Probabilistic assessment of regional mercury exposure显示文摘 | Seigneur C Pai P Gerath M | 1997 | Water air and soil pollution1997，97，： | 1 |
| 6 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 7 | Airway inflammation, basement membrane thickening and bronchial hyperresponsiveness in asthma显示文摘 | Ward C Pais M Bish R | 2002 | Thorax2002，57，4： | 1 |
| 8 | Relationships between Voltage and Angle Stability of Power Systems显示文摘 | Voumas C D Sauer P W Pai M A | 1996 | International Journal of Electrical Power and Energy System1996，，： | 1 |
| 9 | Enabling high-order in- tegration of fatigue crack growth with surrogate modeling显示文摘 | Pais M J Viana F A C Kim N H | 2012 | International Journal of Fatigue2012，43，： | 1 |
| 10 | Radiofrequency-assisted hepatic resection显示文摘 | Pai M Kyriakides C Mikhail S | 2011 | Ann Surg Oncol2011，18，12： | 1 |
| 11 | The effect of isothermal mechanical stirring on an Al-Si alloy in the semisolid condition 显示文摘 | SUKUMARAN K PAI B C CHAKRABORTY M | 2004 | Materials Science and Engineering A2004，369，： | 1 |
| 12 | Functionally graded Al-Al3Ni in situ intermetallic composites:Fabrication and microstructural characterization显示文摘 | D Rajan T P Pillai R M Pai B C | 2008 | Journal of Alloys and Compounds2008，453，12： | 1 |
| 13 | critical roles for transcription factor GATA-3 in thymocyte development显示文摘 | Pai S Y Truitt M L Ting C N | | 0，，： | 1 |
| 14 | 显示文摘 | Hwang T L Pai Y M Liu C S | 1980 | J Am Chem Soc1980，102，25： | 1 |
| 15 | Potential applications of aerobic denitrifiying bacteria as bio-agents in waste water treatment显示文摘 | Pai S L Chong N M Chen C H | 1999 | Bioresource Technology1999，68，2： | 1 |
| 16 | The integration of association rule mining and artificial immune network for supplier selection and order quantity allocation显示文摘 | Kuo R J Pai C M Lin R H | 2015 | Applied Mathematics and Computation2015，250，1： | 1 |
| 17 | Falsepositive tuberculin skin tests: what is the absolute effect of BCG and nontuberculosis mycobacteria?显示文摘 | Farhat M Greenaway C Pai M | 2006 | Int J Tuberc Lung Dis2006，10，11： | 1 |
| 18 | Potential applications of aerobic denitrifiying bacteria as bioagents In waste water treatment显示文摘 | Pai S L Chong N M Chen C H | | 0，，02： | 1 |
| 19 | Improving hierarchical cluster analysis: A new method with outlier detection and automatic clustering显示文摘 | ALMEIDA J A S BARBOSA L M S PAIS A A C C | 2007 | Chemometrics and Intelligent Laboratory Systems2007，87，： | 1 |
| 20 | Two SOX9genes on duplicated zebrafish chromosomes:expression of similar transcription activators in distinct sites显示文摘 | Chiang E F Pai C I Wyatt M | 2001 | Dev Biol2001，231，1： | 1 |
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