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3篇 您的检索式：作者名="Pak Chung Sham"

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		题名	作者	年代	出处	被引量
	1	Statistical issues and approaches in endophenotype research显示文摘The endophenotype concept was initially proposed to enhance the power of genetic studies of complex disorders. It is closely related to the genetic component in a liability-threshold model; a perfect endophenotype should have a correlation of 1 with the genetic component of the liability to disease. In reality, a putative endophenotype is unlikely to be a perfect representation of the genetic component of disease liability. The magnitude of the correlation between a putative endophenotype and the genetic component of disease liability can be estimated by fitting multivariate genetic models to twin data. A number of statistical methods have been developed for incorporating endophenotypes in genetic linkage and association analyses with the aim of improving statistical power. The most recent of such methods can handle multiple endophenotypes simultaneously for the greatest increase in power. In addition to increasing statistical power, endophenotype research plays an important role in helping to understand the mechanisms which connect the associated genetic variants with disease occurrence. Novel statistical approaches may be required for the analysis of the complex relationships between endophenotypes at different levels and how they converge to cause the occurrence of disease.	SHAM Pak Chung CHERNY Stacey S HALL Mei-Hua	2011	Chinese Science Bulletin2011，56，32：	2
	2	A genetic variant in the gene encoding adrenomedullin predicts the development of dysglycemia over 6.4<ce:hsp sp='0.25'/>years in Chinese显示文摘	Kwok Leung Ong Annette W.K. Tso Raymond Y.H. Leung Stacey S. Cherny Pak Chung Sham Tai Hing Lam Bernard M.Y. Cheung Karen S.L. Lam	2010	Clinica Chimica Acta2010，，3：	1
	3	Coagulation factors and the incidence of COVID-19 severity:Mendelian randomization analyses and supporting evidence显示文摘Dear Editor,The evolving pandemic of coronavirus disease 19(COVID-19),is arousing alarm to public health.According to epidemiological and observational investigations,coagulopathy was frequently seen in severe COVID-19 patients1.Some coagulation factors such as D-dimer,prothrombin time(PT);von Willebrand factor(VWF),platelet count,and fibrinogen were documented to be important predictors of critically ill patients with COVID-19 in many retrospective observational studies and were substantially discussed before(see Supplementary Notes),yet the causality from specific coagulation factors to the incidence of COVID-19 severity and the underlying mechanism remains elusive.	Yao Zhou Xinyi Qian Zipeng Liu Hongxi Yang Tong Liu Kexin Chen Yaogang Wang Pak Chung Sham Ying Yu Mulin Jun Li	2021	Signal Transduction and Targeted Therapy2021，6，7：	0

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