|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 非酒精性脂肪性肝病中脂毒性肝细胞来源的外泌体miR-192-5p通过Rictor/Akt/FoxO1信号通路激活巨噬细胞显示文摘【据Hepatology 2020年5月报道】题:非酒精性脂肪性肝病中脂毒性肝细胞来源的外泌体miR-192-5p通过Rictor/Akt/FoxO1信号通路激活巨噬细胞(作者Liu XL等)肝脏巨噬细胞可被多种因素如肠道菌群代谢物以及受损的肝细胞释放物等激活。在非酒精性脂肪性肝病(NAFLD)的发生发展中,巨噬细胞向促炎表型(M1)的极化是一个重要的病理生理过程。外泌体可传递多种生物学成分如microRNA、蛋白质以及脂质等,因此被作为细胞间通讯的重要媒介。在NAFLD的发生发展过程中,外泌体在肝细胞与巨噬细胞对话中的作用尚未明确。 | 刘晓琳 范建高 LIU XL PAN Q CAO HX | 2020 | 临床肝胆病杂志2020，36，10： | 28 |
| 2 | Celecoxib-related gastroduodenal ulcer and cardiovascular events in a randomized trial for gastric cancer prevention显示文摘AIM: To evaluate the long-term risk of gastroduodenal ulcer and cardiovascular events induced by celecoxib in a population-based, randomized, double-blind, placebo-controlled study.METHODS: From 2004 to 2006, a total of 1024 Chinese patients (aged 35 to 64 years) with severe chronic atrophic gastritis, intestinal metaplasia or dysplasia were randomly assigned to receive 200 mg of celecoxib twice daily or placebo in Linqu County (Shandong Province, China), a high-risk area of gastric cancer. All gastroduodenal ulcer and cardiovascular events occurred were recorded and the patients were followed up for 1.5 years after treatment. At the end of the trial, a systematic interview survey about other adverse events was conducted. RESULTS: Gastroduodenal ulcer was detected in 19 of 463 (3.72%) patients who received celecoxib and 17 of 473 (3.31%) patients who received placebo, respectively (odds ratio = 1.13, 95% CI = 0.58-2.19). Cardiovascular (CV) events occurred in 4 patients who received celecoxib and in 5 patients who received placebo, respectively. Compared with those who received placebo, patients who received celecoxib had no signif icant increase in occurrence of CV events (hazard ratio = 0.84, 95% CI = 0.23-3.15). Among the adverse events acquired by interview survey, only the frequency of bloating was signif icantly higher in patients treated with celecoxib than in those treated with placebo. CONCLUSION: Treatment of gastric cancer with celecoxib is not associated with increased risk of gastroduodenal ulcer and cardiovascular events. | Guo-Shuang Feng Jun-Ling Ma Benjamin CY Wong Lian Zhang Wei-Dong Liu Kai-Feng Pan Lin Shen Xiao-Dong Zhang Jie Li Harry HX Xia Ji-You Li Shiu Kum Lam Wei-Cheng You | 2008 | World Journal of Gastroenterology2008，14，28： | 4 |
| 3 | Association ofBLCA-4 Hypomethylati- on in Blood Leukocyte DNA and the Risk of Bladder Cancer in a Chinese Population显示文摘 | Ji HX Zhao Q Pan JH | 2013 | Pathol Oncol Res2013，19，5： | 1 |
| 4 | Comparative pharmaco- kinetics of baicalin in plasma after oral administration of Huang-Lian-Jie-Du-Tang or pure baicalin in MCAO and sham-operated rats显示文摘 | Zeng MF Pan LM Zhu HX | 2010 | Fitoterapia2010，81，6： | 1 |
| 5 | Studies on the reproductive biology and endangerment mechanism of the endangered plant Manglietia aromatica显示文摘 | Pan YZ Liang HX Gong X 2003 | 2003 | Acta Bot Sin2003，45，3： | 1 |
| 6 | In vitro and in vivo immunosup pressive activity of Spica Prunellae ethanol extract on the im- mune responses in mice显示文摘 | Sun HX Qin F Pan YJ | 2005 | J Ethnopharmacol2005，101，13： | 1 |
| 7 | Comparative pharmacokinetics of baicalin in plasma after oral administration of Huang-Lian-Jie-Du-Tang or pure baicalin in MCAO and sham-operated rats显示文摘 | Zeng MF Pan LM Zhu HX | 2010 | Fitoterapia2010，81，6： | 1 |
| 8 | Genetic manipulation revealing an unusual N-terminal region in a stand-alone non-ribosomal peptide synthetase in- volved in the biosynthesis of ramoplanins显示文摘 | Pan HX Li JA Shao L | 2013 | Bio- technology Letters2013，35，1： | 1 |
| 9 | Adjuvant effect of Panax notoginseng saponins on the immune responses to ovalbumin in mice 显示文摘 | Sun HX Ye YP Pan HJ | 2004 | Vaccine2004，22，2930： | 1 |
| 10 | Down-regulation of miR - l/miR - 133 contributes to re - expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart显示文摘 | Luo XB Lin HX Pan ZW | 2008 | Biolo Chem2008，283，20： | 1 |
| 11 | Comparative pharmacokinetics of baicalin in plasma after oral administration of Huang-Lian-Jie-Du- Tang or pure baicalin in MCAO and sham-operated rats显示文摘 | Zeng MF Pan LM Zhu HX | 2010 | Fitotera- p/a2010，8，： | 1 |
| 12 | In vitro and in vivo immunosuppressive activity of Spica Prunellae ethanol extract on the immune responses in mice显示文摘 | Sun HX Qin F Pan YJ | | 0，，： | 1 |
| 13 | Adjuvant effect of Panax notoginseng saponins on the immune responses to ovalbumin in mice 显示文摘 | Sun HX Ye YP Pan H J | 2004 | Vaccine2004，22，： | 1 |
| 14 | Novel polysaccharide adjuvant from the roots of Actinidia eriantha with dual Thl and Th2 potentiating activity 显示文摘 | Sun HX Ye YP Pan H J | 2009 | Vaccine2009，27，30： | 1 |
| 15 | Comparative pharmacokinetics of baicalin in plasma after oral administration of Huang-Lian-Jie-Du-Tang or pure baicalin in MCAO and sham-operated rats显示文摘 | Zeng MF Pan LM Zhu HX | | 0，，06： | 1 |
| 16 | In vitro and in vivo immunosuppressive activity of Spica Prunellae ethanol extracton the immune responses in mice显示文摘 | Sun HX Qin F Pan YJ | 2005 | J Ethnopharmacol2005，5，23： | 1 |
| 17 | Study and clinical application of a porcine biomembrane for the repair of dural defects显示文摘 | Xu BZ Pan HX Li KM | | 0，，05： | 1 |
| 18 | Telbivudine prevents ver- tical transmission from HBeAg-positive women with chronic hepatitis B 显示文摘 | Pan CQ Han GR Jiang HX | 2012 | Clinical Gastroenterol Hepatol2012，10，5： | 1 |
| 19 | Correlation between TAMs and proliferation and invasion of typeⅠendometrial carcinoma显示文摘 | Hu HL Bai HS Pan HX | 2015 | Asian Pac J Trop Med2015，8，： | 1 |
| 20 | Immunological adjuvant effect of Glyc- yrrhiza uralensis saponins on the immune responses to ov- albumin in mice显示文摘 | Sun HX Pan HJ | 2006 | Vaccine2006，24，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员