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| 1 | Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells显示文摘Long-range communication between intestinal symbiotic bacteria and extra-intestinal organs can occur through circulating bacterial signal molecules, through neural circuits, or through cytokines or hormones from host cells. Here we report that Nod1 ligands derived from intestinal bacteria act as signal molecules and directly modulate insulin trafficking in pancreatic beta cells. The cytosolic peptidoglycan receptor Nod1 and its downstream adapter Rip2 are required for insulin trafficking in beta cells in a cell-autonomous manner. Mechanistically, upon recognizing cognate ligands, Nod1 and Rip2 localize to insulin vesicles, recruiting Rab1a to direct insulin trafficking through the cytoplasm. Importantly, intestinal lysozyme liberates Nod1 ligands into the circulation, thus enabling long-range communication between intestinal microbes and islets. The intestine-islet crosstalk bridged by Nod1 ligands modulates host glucose tolerance. Our study defines a new type of inter-organ communication based on circulating bacterial signal molecules, which has broad implications for understanding the mutualistic relationship between microbes and host. | Qin Zhang Ying Pan Benhua Zeng Xiaojiao Zheng Haifang Wang Xueying Shen Hui Li Qian Jiang Jiaxu Zhao Zhuo-Xian Meng Pingping Li Zhengjun Chen Hong Wei Zhihua Liu | 2019 | Cell Research2019，29，7： | 11 |
| 2 | Large lattice mismatch induced perpendicular magnetic anisotropy and perpendicular exchange bias in CoPt/FeMn bilayer films显示文摘Perpendicular magnetic anisotropy and perpendicular exchange bias of CoPt/FeMn bilayers fabricated by dc magnetron sputtering were investigated in this work.Magnetic anisotropy,showing strong dependence on thickness of CoPt layer,changes from perpendicular magnetic anisotropy(PMA) into in-plane magnetic anisotropy when CoPt layer is thicker than 4.5 nm.The evolution of internal stress with thickness,from tensile to compressive,has been analyzed by sin^2 ψ method using an equal biaxial stress model.Distinctive perpendicular exchange bias(PEB) has been successfully established due to PMA of CoPt and out-ofplane spin component of 3 Q-spin-structured FeMn.FeMn thickness dependence of exchange bias field has been systematically investigated. | PAN ChunJiao GAO TengHua ITOGAWA Nobuhide HARUMOTO Takashi ZHANG ZhengJun NAKAMURA Yoshio SHI Ji | 2019 | Science China(Technological Sciences)2019，62，11： | 2 |
| 3 | Using Evolutionary Computation to Solve Problems in Nonparametric Regression显示文摘This paper studies evolutionary mechanism of parameter selection in the construction of weightfunction for Nearest Neighbour Estimate in nonparametrlc regresslon. Construct an algorithm which adagetively evolves fine weight and makes good prediction about unknown points. The numerical experiments indicate that this method is errective. It is a meaningful discussion about practicability of nonparametric regression and methodology or adaptive model-building. | Ding Lixin Kang Lishan Chen Yuping Pan Zhengjun | 1998 | Wuhan University Journal of Natural Sciences1998，3，1： | 2 |
| 4 | Diagnostic efficacy of whole-body diffusion-weighted imaging in the detection of tumour recurrence and metastasis by comparison with 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography or computed tomography in patients with gastrointestinal cancer显示文摘Objective:The primary aim of this study was to assess the efficacy of whole-body diffusion-weighted imaging(WB-DWI)in detecting tumour recurrence and metastasis of gastrointestinal cancers by comparison with 18F-2-fluoro-2-deoxy-Dglucose positron emission tomography or computed tomography(18F-FDG-PET/CT).A secondary aim was to evaluate the change of apparent diffusion coefficient(ADC)value between metastases and normal tissues.Methods:Twenty-eight previously confirmed gastrointestinal cancer patients with suspected tumour recurrence or metastasis were recruited.WB-DWI and PET/CT images were evaluated by two radiologists and a nuclear medicine physician.Agreement between WB-DWI and PET/CT for detective efficacy was compared using kappa statistics.Additionally,diagnostic accuracy,sensitivity,specificity,negative predictive value(NPV),and positive predictive value(PPV)were also statistically analysed.ADC values between metastatic and normal tissues were compared.Results:There was no statistically significant difference(P>0.05)in the overall diagnostic performances of PET/CT(accuracy 98.9%;sensitivity 95.2%;specificity 99.8%;PPV 98.9%;NPV 98.9%)and WB-DWI(accuracy 95.9%;sensitivity 81.7%;specificity 99.1%;PPV 95.0%;NPV 96.1%).WB-DWI showed agreement with PET/CT(j=0.877)for detecting recurrence and distant metastases.A statistically significant difference in ADC value was observed between tissues of normal healthy volunteers and metastases in lymph nodes,liver and bones(P<0.05).Conclusions:WB-DWI is reliable in detecting tumour recurrence and metastasis of colorectal cancer and offers the same diagnostic performance as 18F-PET/CT without ionizing radiation.The quantitative value of ADC provides extra information to determine cancer metastasis. | Jiaying Gong Wuteng Cao Zhanwen Zhang Yanhong Deng Liang Kang Pan Zhu Zhengjun Liu Zhiyang Zhou | 2015 | Gastroenterology Report2015，3，2： | 1 |
| 5 | Evolving both the topology and weights of neural network 显示文摘 | Pan Zhengjun Kang Lishan Nie Sixiang | 1996 | Parallel Algorithms and Applications1996，9，3： | 1 |
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