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| 1 | Isolation of circulating tumor cells in non-small-cell-lung-cancer patients using a multi-flow microfluidic channel显示文摘Circulating tumor cells(CTCs)carry a wealth of information on primary and metastatic tumors critical for precise cancer detection,monitoring,and treatment.Numerous microfluidic platforms have been developed in the past few years to capture these rare cells in patient bloodstream for deciphering the critical information needed.However,the practical need for a high-quality method of CTC isolation remains to be met.Herein,we demonstrate a novel multi-flow microfluidic device that is able to sensitively provide high purity(>87%)of separation outcome without labeling.Our device is constructed and configured based on the phenomenal effect of size-dependent inertial migration.The recovery rate of>93%has been achieved using spiked cancer cells at clinically relevant concentrations(10 cells per 5 mL and above).We have also successfully detected CTCs from 6 out of 8 non-small-cell-lung-cancer(NSCLC)patients,while none for 5 healthy control subjects.With these results,we envision our approach is a promising alternative for reliable CTC capture,and thus for facilitating the progress of extracting information from CTCs to personalize treatment strategies for solid tumor patients. | Jian Zhou Arutha Kulasinghe Amanda Bogseth Ken O’Byrne Chamindie Punyadeera Ian Papautsky | 2019 | Microsystems & Nanoengineering2019，5，1： | 9 |
| 2 | 查看详情显示文摘 | Bhagat A A S Kuntaegowdanahalli S S Papautsky I | | 0，，： | 1 |
| 3 | Laminar Fluid Behavior in Micro-Channels Using Micropolar Fluid Theory显示文摘 | Papautsky I Brazzle J Aneel T | | 0，，： | 1 |
| 4 | Enhanced particle filtration in straight microchannels using shear-modulated inertial migration 显示文摘 | Bhagat AA Kuntaegowdanahalli SS Papautsky I | 2008 | Phys Fluids2008，20，10： | 1 |
| 5 | Continuous particle separation in spiral microchannels using dean flows and differential migration 显示文摘 | Bhagat AAS Kuntaegowdanahalli SS Papautsky I | 2008 | Lab Chip2008，8，： | 1 |
| 6 | Laminar fluid behavior in microchannels using micropolar fluid theory显示文摘 | PAPAUTSKY I BRAZZLE J AMEEL T | 1999 | Sensors and Actuators A:Physical1999，73，1： | 1 |
| 7 | Inertial microfluidics for continuous particle filtration and extraction 显示文摘 | Bhagat AAS Kuntaegowclanahalli SS Papautsky I | 2009 | Microfluid Nanofluid2009，7，： | 1 |
| 8 | Polymer Embossing Tools for Rapid Prototyping of Plastic Microfluidic Devices显示文摘 | Narasimhan J Papautsky I | 2004 | Journal of Micromechanics and Microengineering2004，14，1： | 1 |
| 9 | Continuous particle separation in spiral microchannels using dean flows and differential migration 显示文摘 | BHAGAT A A KUNTAEGOWDANAHALLI S S PAPAUTSKY I | 2008 | Lab Chip2008，8，11： | 1 |
| 10 | Enhanced Particle Filtration in Straight Microchannels Using Shear-Modulated Inertial Migration 显示文摘 | Bhagat A A S Kuntaegowdanahalli S S Papautsky I | 2008 | Physics of Fluids (1994-present)2008，20，10： | 1 |
| 11 | Effect of recess dimen-sions on performance of the needle-type dissolved oxy- gen microelectrode sensor显示文摘 | Lira T S Lee J H Papautsky I | 2009 | Sensors and Actuators B2009，141，1： | 1 |
| 12 | A passive planar mieromixer with obstructions for mixing at low Reynolds numbers 显示文摘 | BHAGAT A A S PETERSON E T K PAPAUTSKY I | 2007 | J of Micromechanics and Microengineering2007，17，5： | 1 |
| 13 | Laminar fluid behavior in microcharmels using micropolar fluid theory显示文摘 | Papautsky I Brazzle J Ameel T | 1999 | Sensors and Actuators1999，73，： | 1 |
| 14 | Mapping inertial migration in the cross section of a microfluidic channel with high-speed imaging显示文摘The wide adoption of inertial microfluidics in biomedical research and clinical settings,such as rare cell isolation,has prompted the inquiry of its underlying mechanism.Although tremendous improvement has been made,the mechanism of inertial migration remains to be further elucidated.Contradicting observations are not fully reconciled by the existing theory,and details of the inertial migration within channel cross sections are missing in the literature.In this work,for the first time,we mapped the inertial migration pathways within channel cross section using high-speed imaging at the single-particle level.This is in contrast to the conventional method of particle streak velocimetry(PSV),which provides collective information.We also applied smoothed particle hydrodynamics(SPH)to simulate the transient motion of particles in 3D and obtained cross-sectional migration trajectories that are in agreement with the high-speed imaging results.We found two opposing pathways that explain the contradicting observations in rectangular microchannels,and the force analysis of these pathways revealed two metastable positions near the short walls that can transition into stable positions depending on the flow condition and particle size.These new findings significantly improve our understanding of the inertial migration physics,and enhance our ability to precisely control particle and cell behaviors within microchannels for a broad range of applications. | Jian Zhou Zhangli Peng Ian Papautsky | 2020 | Microsystems & Nanoengineering2020，6，1： | 1 |
| 15 | A passive planar micro-mixer with obstructions for mixing at low reynolds numbers显示文摘 | Ali Asgar S Bhagat Erik T K Peterson Ian Papautsky | 2007 | Journal of Micromechanics and Microengineering2007，17，： | 1 |
| 16 | Laminar fluid behavior in rnicrochannels using micropolar fluid theory显示文摘 | I Papautsky J Brazzle T Ameel | 1999 | Sensors and Actuators1999，73，2： | 1 |
| 17 | Effect of recess di- mensions on performance of the needle-type dissolved oxygen microelectrode sensor 显示文摘 | LIM T S LEE J H PAPAUTSKY I | 2009 | Sensors and Actuators: B2009，141，1： | 1 |
| 18 | Enhancing particle dispersion in a passive planar micromixer using rectangular obstacles 显示文摘 | ASGAR A BHAGAT S PAPAUTSKY I | 2008 | Journal of Micromechanics and Microengineering2008，18，8： | 1 |
| 19 | Enhanced Particle Filtration in Straight Microchannels Using Shear-Modulated Inertial Migration 显示文摘 | Bhagat A A S Kuntaegowdanahalli S S Papautsky I | 2008 | Physics of Fluids (1994-Present)2008，20，10： | 1 |
| 20 | Laminar fluid behavior in microchannels using micropolar fluid theory显示文摘 | Papautsky I Brazzle J Ameel T et ai | 1999 | Sensors and Actuators A:Physical1999，73，12： | 1 |
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