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| 1 | Modulating Wnt signaling to improve cell replacement therapy for Parkinson's disease显示文摘临床的试用为多巴胺神经原表明了能力,宫外地移植了进 striatum 到 structurallyintegrate ,恢复多巴胺传播,并且导致长期的功能的好处因为 Parkinson 是疾病( PD ) patients.Despite 原则的这个证明,很多限制在 thepast 上妨碍了房间代替治疗的开发 20 年,特别地主机大脑的织物可获得性,接枝幸存,和足够的神经分布。与在优先的临床的试用的失败的 greaterunderstanding,增加了中脑多巴胺的知识开发(包括 Wnts 的现在) ,和 pluripotent 干细胞技术的发展,我们更好比平常被装备使重新致力很多 thesechallenges。这评论为 PD 在房间代替治疗总结试用,磨难,和进步。我们讨论正规的 modulating 和发信号改进在 dopamineneural 开发和成年大脑在他们的角色之上基于的房间治疗的不在经典中的 Wnt 的 theprospects。这将包括 Wnts 的潜力到(i) 在 vitro 和后面的移植扩展胎儿地导出的织物,(ii ) 支持 pluripotent 干细胞的区别,(iii ) 增加神经电路的接枝 integrationand 恢复,并且(iv ) 最后提高接枝幸存。 | Clare L. Parish Lachlan H. Thompson | 2014 | Journal of Molecular Cell Biology2014，8，1： | 5 |
| 2 | Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers显示文摘Background: Vitamin A and its metabolite,retinoic acid(RA),are important regulators of cell differentiation and organ morphogenesis.Its impact on beef cattle muscle growth remains undefined.Method: Angus steer calves were administrated with 0(control) or 150,000 IU vitamin A(retinyl palmitate in glycerol,i.m.) per calf at birth and 1 month of age.At 2 months of age,a biopsy of the Biceps femoris muscle was obtained to analyze the immediate effects of vitamin A injection on myogenic capacity of muscle cells.The resulting steers were harvested at 14 months of age.Results: Vitamin A administration increased cattle growth at 2 months.At 2 months of age,Vitamin A increased PAX7 positive satellite cells and the expression of myogenic marker genes including PAX7,MYF5,MYOD and MYOG.Muscle derived mononuclear cells were further isolated and induced myogenesis in vitro.More myotubes and a higher degree of myogenesis was observed in vitamin A groups.Consistently,vitamin A increased Latissimus dorsi(LD) muscle fiber size at harvest.In addition,vitamin A increased the ratio of oxidative type I and type IIA fibers and reduced the glycolic type IIX fibers.Furthermore,we found that RA,a key bioactive metabolite of vitamin A,activated PPARGC1 A promoter,which explains the upregulated expression of PPARGC1 A in skeletal muscle.Conclusion: Vitamin A administration to neonatal calves enhanced postnatal muscle growth by promoting myogenesis and increasing satellite cell density,accompanied with a shift to oxidative muscle fibers. | Bo Wang Wei Nie Xing Fu Jeanene M de Avila Yannan Ma Mei-Jun Zhu Martin Maquivar Steven M Parish Jan R Busboom Mark L Nelson Min Du | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 3 |
| 3 | Optimized Formulation of Magnetic Chitosan Microspheres Containing the Anticancer Agent显示文摘 | Hassan F F Parish R C Gallo J M | 1992 | Oxantrazole Pharm Res1992，9，3： | 2 |
| 4 | Impact of lipoprotein(a) levels and apolipoprotein(a) isoform size on risk of coronary heart disease显示文摘 | J. C. Hopewell U. Seedorf M. Farrall S. Parish T. Kyriakou A. Goel A. Hamsten R. Collins H. Watkins R. Clarke | 2014 | J Intern Med2014，，3： | 2 |
| 5 | Identificatin of sulfated oligosaccharide based inhibitors of tumor growth and metastasis using novel in vitro assays for anigiogenesis and heparanase activity 显示文摘 | Parish CR Freeman C Brown K J | 1999 | Cancer Res1999，59，： | 1 |
| 6 | Clarithromycin in the treatment of skin and skin structure infections:two multicenter clinical studies显示文摘 | | 1993 | Int J1993，32，7： | 1 |
| 7 | SLCO1B1 variants and statin-induced myopathy-A genomewide study显示文摘 | LINK E PARISH S ARMITAGE J | 2008 | N Engl J Med2008，359，8： | 1 |
| 8 | Effects of auxin and abscisic acid cytosolic and PH in plant cells显示文摘 | GEHRING C A IRIVING H R PARISH R W | 1990 | Proc Natl Acad Sci USA1990，87，： | 1 |
| 9 | Blockade of vascular smooth muscle cell proliferation and intimal thickening after balloon injury by the sulfated oligosaccharide PI-88:phosphomannopentaose sulfate directly binds FGF-2,blocks cellular signaling,and inhibits proliferation显示文摘 | Francis DJ Parish CR McGarry M | 2003 | Circ Res2003，92，8： | 1 |
| 10 | A method for the esterification of sterication hindered carboxylic acids显示文摘 | Stock LM | 1964 | Tetra Lett1964，，20： | 1 |
| 11 | Acne rosacea and Helicobacter Pylori betrothed显示文摘 | Josph A Witkowski | 1995 | Int J Dermatol1995，34，： | 1 |
| 12 | SLCO1B1 variants and statin-induced myopathy--a genomewide study显示文摘 | Wilhelmsen L Link E Parish S | 2008 | New Engl JMed2008，359，： | 1 |
| 13 | Large-scale evidence that the cardiotoxicity of smoking is not ignificantly modified by the apolipoprotein E2 /E3/E4 genotype显示文摘 | Keavney B Parish S Palmer A | 2003 | Lancet2003，361，9355： | 1 |
| 14 | The human papillomavirus (HPV) 16, E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway显示文摘 | Webster K Parish J Pandya M | 2000 | J Biol Chemistry2000，275，1： | 1 |
| 15 | Identification of sulfated oligosaccharide-based inhibitors of tumor growth and metastasis using novel in vitro assays for angiogenesis and heparanase activity 显示文摘 | Parish CR Freeman C Brown K J | 1999 | Cancer Res1999，59，14： | 1 |
| 16 | Fertigation uniformity affected by injector type 显示文摘 | Bracy R P Parish R L Rosendale R M | 2003 | Hort Technology2003，13，1： | 1 |
| 17 | Effects of cholesterol lowering with simvastatin on stroke and other major vascular events in 20 536 people with cerebrovascular disease or other high-risk conditions显示文摘 | Collins R Armitage J Parish S | 2004 | Lancet2004，363，9411： | 1 |
| 18 | Non-Saturating Magnetoresistance in Heavily Disordered Semiconductors显示文摘 | Parish M M Littlewood P B | 2003 | Nature2003，426，： | 1 |
| 19 | Sexual practices and sexual satisfaction:a population based study of Chinese urban adults显示文摘 | PARISH W L LUO Ye STOLZENBERG R | 2007 | Archives of Sexual Behavior2007，36，1： | 1 |
| 20 | 标准型、缺口型和螺旋缺口型圆盘耙性能比较(摘选) | Parish P.Nalavade Peeyush Soni Vilas M.Salokhe Tanya Niyamapa | 2012 | 农业工程2012，2，2： | 1 |
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