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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Time course of sleep - relatedbreathing disorders in first - ever stroke or transient ischemic attack显示文摘 | Parra O Arboix A Bechich S | 2000 | Am J Re-spir Crit Care Med2000，161，： | 1 |
| 3 | Time Course of Sleep-related Breathing Disorders in First-ever Stroke or TIA显示文摘 | Parra O Arboix A Bechich S | 2000 | Am J Respir Crit Care Med2000，161，2： | 1 |
| 4 | The amino termi- nal sequence of VP60 from rabbit hemorrhagic disease virus supports its putative subgenomic origin显示文摘 | Parra F Boga J A Matin M S | 1993 | Vi- rus Res1993，27，3： | 1 |
| 5 | Photochemical versus coupled photochemical-biological flow system for the treatment of two biorecal-citrant herbicides:metobromuron and isoproturon显示文摘 | Parra S Sarria V Malato S | 2000 | Applied Catalysis B-Environmental2000，27，3： | 1 |
| 6 | Oxidative stress by Helicobacter pylofi causes apoptosis through mitochondrial pathway in gastric epithelial cells显示文摘 | Calvino - FernOndez M Benito - Martinez S Parra - Cid T | 2008 | Apoptosis2008，13，10： | 1 |
| 7 | Photochemical Versus Coupled Photochemical-biological Flow System for the Treatment of Two Biorecalcitrant Herbicides:Metobromuron and Isoproturon显示文摘 | PARRA S SARRIA V MALATO S | 2000 | Applied Catalysis B:Environmental2000，27，： | 1 |
| 8 | Very high resolution interpolated climate surfaces for global land areas显示文摘 | Hijmans R J Cameron S E Parra J L | 2005 | International Journal of Climatology2005，25，15： | 1 |
| 9 | Participa- tion of vasoactive intestinal polypeptide in ovarian ster- oids production during the rat estrous cycle and in the development of estradiol valerate-induced polycystic ova- ry显示文摘 | Claudio Parra Jenny L F Leticia S Luna | 2007 | Biol Reprod2007，133，1： | 1 |
| 10 | Time course of sleep-related breathing disorders in first-ever stroke or transient ischemic attack显示文摘 | Parra O Arbix A Bechich S | 2000 | Am J Respir Crit care Med2000，16，2： | 1 |
| 11 | Photocatalytic degradation of atrazine using suspended and supported TiO2 显示文摘 | Parra S Stanca S E Guasaquillo I | 2004 | Applied Catalysis B: Environmental2004，51，2： | 1 |
| 12 | Very high resolution interpolated climate surfaces for global land areas显示文摘 | Hijmans R J Cameron S E Parra J L | 2005 | International Journal of Climatology2005，25，15： | 1 |
| 13 | Optimizing solar photocatalytic mineralization of pesticides by adding inorganic oxidizing species: application to the recycling of pesticide containers 显示文摘 | Parras S Sarria V Malato S | 2000 | Appl Catal B: Environ2000，28，： | 1 |
| 14 | Attenuation of sucrose consumption in mice by chronic mild stress and its restoration by imipramine 显示文摘 | D′Aquila P Parra A | 1995 | Psychopharmacology1995，117，4： | 1 |
| 15 | Very High Reso lution Interpolated Climate Surfaces for Global Land Areas显示文摘 | Hijmans R J Cameron S E Parra J L | 2005 | International Journal of Climatology2005，25，： | 1 |
| 16 | Statisticalindependence and novelty detection with informationpreserving nonlinear maps显示文摘 | PARRA L DECO G MIESBACH S | 1996 | Neural Computation1996，8，2： | 1 |
| 17 | Quantification of cytokine gene expression using an economical real-time polymerase chain reaction method based on SYBR green Ⅰ显示文摘 | PAYAN R R MEDINA M A PARRA S E | 2003 | ScandJ Immunol2003，57，5： | 1 |
| 18 | Very high resolution interpolated climate surfaces for global land areas 显示文摘 | Hijmans R Cameron S Parra J | 2005 | International Journal of Climatology ~2005，25，15： | 1 |
| 19 | Discoloration of Azo-dyes at Biocompatible pH-values Though an Fe-histidine Complex Immobilized on Nation vis Fenton-like Processes显示文摘 | Parra S Nadtotechenko V Kiwi J | 2004 | Journal of Physical Chemistry B2004，108，： | 1 |
| 20 | Effect of prior statin use on functional outcome and delayed vasospasm after acute aneurysmal subarachnoid hemorrhage:a matched controlled cobort study显示文摘 | Parra A Kreiter KT Williams S et al | 2005 | Neurosurgery2005，56，3： | 1 |
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