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| 1 | Prevalence of anal fistula in the United Kingdom显示文摘BACKGROUND Anal fistula is a pathological connection between the anal canal and perianal skin, which most commonly develops from an infected anal crypt. While the majority of anal fistulas are idiopathic, they are also associated with Crohn’s disease (CD) and other inflammatory conditions. The prevalence of anal fistula is estimated to be 1-2 per 10000 patients, but population-based studies on anal fistula epidemiology are limited and outdated. AIM To assess the prevalence of anal fistula and relevant comorbidities, with and without CD in the United Kingdom and Europe. METHODS A retrospective population-representative observational cohort study was performed in The Health Improvement Network (THIN), a United Kingdom primary care database. Mid-year point prevalence of anal fistula was calculated on the first of July for each year between 2014 and 2017. Estimates were calculated for anal fistula overall and by CD status and standardized to the United Kingdom and European population. Prevalence of relevant comorbidities including lymphogranuloma venereum, hidradenitis suppurativa, anal presentation of sexually transmitted diseases, diabetes mellitus, and radiation in the pelvic area was reported. RESULTS The United Kingdom-standardized overall point prevalence of anal fistula was 1.80 (95%CI: 1.65-1.94) per 10000 patients in 2017, while the Europe standardized estimate was 1.83 (95%CI: 1.68-1.98) per 10000 patients. Both these standardized point prevalence estimates ranged from 1.89 to 2.36 between 2014-2016. The United Kingdom-standardized point prevalence of anal fistula without CD was 1.35 (95%CI: 1.23-1.48) per 10000 patients, while the Europe-standardized estimate was 1.39 (95%CI: 1.26-1.52) per 10000 patients. In contrast, the standardized point prevalence estimate of anal fistula with CD was lower for both United Kingdom and Europe (0.44;95%CI United Kingdom: 0.37-0.52, 95%CI Europe: 0.37-0.51) per 10000 patients in 2017. In 2017, 19% of anal fistula patients without CD and 13% of anal fistula patients with CD had at least one relevant comorbidity. These results show that anal fistulas are infrequent in the general population. 24.5% of prevalent anal fistulas are associated with CD, but other potentially etiological comorbidities are rare. CONCLUSION This real-world evidence study estimated the United Kingdom-standardized prevalence of anal fistula was 1.80 per 10000 patients in 2017. Approximately 25% of cases may be associated with CD, while other comorbidities are rare. | Suvi RK Hokkanen Naomi Boxall Javaria Mona Khalid Dimitri Bennett Haridarshan Patel | 2019 | World Journal of Clinical Cases2019，7，14： | 7 |
| 2 | Major depressive disorder in the African American population 显示文摘 | Bailey RK Patel M Barker NC | 2011 | J Natl Med Assoe2011，103，7： | 1 |
| 3 | NGS QC Toolkit: a toolkit for quality control of next generation sequencing data 显示文摘 | Patel RK Jain M | 2012 | PLoS One2012，7，30： | 1 |
| 4 | Prevalence of the activating JAK2 tyrosine kinase mutation V617F in the Budd-Chiari syndrome显示文摘 | LEA NC HENEGHAN MA | 2006 | Gastroenterology2006，130，： | 1 |
| 5 | Presenting D-di- mer and ear|y symptom severity are independent predictors for post- thrombotic syndrome following a first deep vein thrombosis 显示文摘 | ROBERTS LN PATEL RK CHITONGO PB | 2013 | Br J Haematol2013，160，6： | 1 |
| 6 | Prospective analysis ofthe association of infection with CagA bearing strains of Helicobacterpylori and coronary heart disease显示文摘 | Singh RK McMahon AD Patel H | 2002 | Heart2002，88，1： | 1 |
| 7 | Oxidized-phosphotipids in reconstituted high density lipoprotein particles affect structure and function of recombinant paraoxonase 1 显示文摘 | Kar S Patel MA Tripathy RK | 2013 | Biochim Biophys Acta2013，1831，12： | 1 |
| 8 | NGS QC Toolkit: a toolkit for quality control of next generation sequencing data 显示文摘 | Patel RK Jain M | 2012 | PLoS One2012，7，30： | 1 |
| 9 | The Role of endorectal ultrasound and magnetic resonance imaging in the management of early rectal lesions in a tertiary center 显示文摘 | Patel RK Sayers AE Kumar P | 2014 | Clin Colorectal Cancer2014，13，： | 1 |
| 10 | Prevalence of the activating JAK2 tyrosine kinase mutation V617F in the Budd-Chiari syndrome 显示文摘 | Patel RK Lea NC Heneghan MA | 2006 | Gastroenterology2006，130，7： | 1 |
| 11 | Internal jugular veinthrombosis after assisted conception therapy显示文摘 | Arya R Shehata HA Patel RK | 2001 | Br J Haemato2001，115，1： | 1 |
| 12 | Internal jugular vein thrombosis after assisted conception therapy 显示文摘 | Arya R Shehata HA Patel RK | 2001 | Br J Haematol2001，115，1： | 1 |
| 13 | A Systematic Literature Review of Nonsurgical Treatment in Adult Scoliosis显示文摘 | Everett CR Patel RK | 2007 | Spine2007，32，19： | 1 |
| 14 | Changes in thrombin genera- tion and D-dimer concentrations in women injecting enoxaparin during pregnancy and the puerperium显示文摘 | Patel JP Patel RK Roberts LN | 2014 | BMC Pregnancy Childb- irth2014，14，1： | 1 |
| 15 | Evaluation of stress and strain distribution in endodontically treated maxillary central incisor with two different post and core systems-A 3D Finite element analysis显示文摘 | Agarwal A Patel RK Kalavathy N | 2011 | Inter-national J Prosthetic Dentistry2011，2，2： | 1 |
| 16 | Haemostasis and thrombosis in liver disease显示文摘 | Roberts LN Patel RK Arya R | 2010 | Br J Haematol2010，148，4： | 1 |
| 17 | Comparidson of ketoprofen, piroxicam, and diclofenac gels in the treatment of acute softtissue injury in general practice显示文摘 | Patel RK Leswell PF | 1996 | Clin Ther1996，18，3： | 1 |
| 18 | Elevated erythropoietin mRNA and protein concentrations in the developing human eye 显示文摘 | Patel S Rowe M J Winters SA Ohls RK | 2008 | Pediatr Res2008，63，4： | 1 |
| 19 | How to identify and mange diabetes mellitus after renal transplantation显示文摘 | Stevens KK Patel RK Jardine AG | | 0，，： | 1 |
| 20 | Comparative analysis of dendritic cell density and total number in commonly transplanted organs: morphometric estimation in normal mice显示文摘 | Patel RK Subbotin VM | 2000 | Transpl Immunol2000，8，1： | 1 |
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