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| 1 | 固定低剂量三联抗高血压药物与常规治疗对斯里兰卡轻度至中度高血压患者血压控制的疗效差异:一项随机临床试验显示文摘控制不良的高血压是全球领先的公共卫生问题,需要新的治疗策略。该研究评估低剂量三联抗高血压药物治疗是否能达到比常规治疗更好的血压控制。研究者纳入2016年2月至2017年5月在斯里兰卡11所城市医院诊所就诊的需要开始抗高血压治疗(未治疗的患者)或接受单药治疗的患者,进行低剂量三联降压与常规治疗比较的随机、开放性试验,随访至2017年10月。 | Web-ster R Salam A de Silva HA Selak V Stepien S Rajapakse S Amarasekara S Amarasena N Billot L de Silva AP Fernando M Guggilla R Jan S Jayawardena J Maulik PK Mendis S Munasinghe J Naik N Prabhakaran D Ranasinghe G Thom S Tisserra N Senaratne V Wijekoon S Wijeyasingam S Rodgers A Patel A 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 7 |
| 2 | Predictors of spine deformity progression in adolescent idiopathic scoliosis: A systematic review with meta-analysis显示文摘AIM: To evaluate published data on the predictors of progressive adolescent idiopathic scoliosis(AIS) in order to evaluate their efficacy and level of evidence. METHODS: Selection criteria:(1) study design: randomized controlled clinical trials, prospective cohort studies and case series, retrospective comparative and none comparative studies;(2) participants: adolescents with AIS aged from 10 to 20 years; and(3) treatment: observation, bracing, and other. Search method: Ovid MEDLINE, Embase, the Cochrane Library, Pub Medand patent data bases. All years through August 2014 were included. Data were collected that showed an association between the studied characteristics and the progression of AIS or the severity of the spine deformity. Odds ratio(OR), sensitivity, specificity, positive and negative predictive values were also collected. A metaanalysis was performed to evaluate the pooled OR and predictive values, if more than 1 study presented a result. The GRADE approach was applied to evaluate the level of evidence.RESULTS: The review included 25 studies. All studies showed statistically significant or borderline association between severity or progression of AIS with the following characteristics:(1) An increase of the Cobb angle or axial rotation during brace treatment;(2) decrease of the rib-vertebral angle at the apical level of the convex side during brace treatment;(3) initial Cobb angle severity(> 25o);(4) osteopenia;(5) patient age < 13 years at diagnosis;(6) premenarche status;(7) skeletal immaturity;(8) thoracic deformity;(9) brain stem vestibular dysfunction; and(10) multiple indices combining radiographic, demographic, and physiologic characteristics. Single nucleotide polymorphisms of the following genes:(1) calmodulin 1;(2) estrogen receptor 1;(3) tryptophan hydroxylase 1;(3) insulin-like growth factor 1;(5) neurotrophin 3;(6) interleukin-17 receptor C;(7) melatonin receptor 1B, and(8) Scoli Score test. Other predictors included:(1) impairment of melatonin signaling in osteoblasts and peripheral blood mononuclear cells(PBMC);(2) G-protein signaling dysfunction in PBMC; and(3) the level of platelet calmodulin. However, predictive values of all these findings were limited, and the levels of evidence were low. The pooled result of brace treatment outcomes demonstrated that around 27% of patents with AIS experienced exacerbation of the spine deformity during or after brace treatment, and 15% required surgical correction. However, the level of evidence is also low due to the limitations of the included studies.CONCLUSION: This review did not reveal any methods for the prediction of progression in AIS that could be recommended for clinical use as diagnostic criteria. | Andriy Noshchenko Lilian Hoffecker Emily M Lindley Evalina L Burger Christopher MJ Cain Vikas V Patel Andrew P Bradford | 2015 | World Journal of Orthopedics2015，6，7： | 4 |
| 3 | Routine sectioning of the C2 nerve root and ganglion for C1 lateral mass screw placement in children: surgical and functional out- comes显示文摘 | Patel A J Gressot L V Boatey J | 2013 | Childs Nerv Syst2013，29，1： | 1 |
| 4 | Assessment of upper esophageal sphincter function on high-resolution manometry: identification of predictors of globus symptoms 显示文摘 | Peng L Patel A Kushnir V | 2015 | J Clin Gastroenterol2015，49，2： | 1 |
| 5 | Micro Scale Row Behav- ior and Void Formation Mechanism During Impregna- tion Through a Unidirectional Stitched Fiberglass Mat显示文摘 | Patel N Rohatgi V Lee L J | 1995 | Polymer Engineering and Science1995，35，10： | 1 |
| 6 | Thiol-ene Reactions of 1,3,5-Triacryloylhexahydro-1,3,5-Triazine (TAT) : Facile Access to Functional Tripodal Thioethers显示文摘 | Rim C Lahey L J Patel V G | 2009 | Tetrahedron Letters2009，50，7： | 1 |
| 7 | Outcomes 5 years after re- sponse to rituximab therapy in children and adults with immune thrombocytopenia显示文摘 | Patel V L Mahvas M lee S Y | 2012 | Blood2012，119，25： | 1 |
| 8 | Pediatric muhip|e sclerosis显示文摘 | Patel Y Bhise V Krupp L | 2009 | Ann Indian Acad Neurol2009，12，4： | 1 |
| 9 | Hematuria : etiology and eval- uation for the primary care physician 显示文摘 | Patel J V Chambers C V Gomella L G | 2008 | Can J Uro12008，151，： | 1 |
| 10 | Acute kidney injury and aberrantplanar cell polarity induce cyst formation in mice lacking renal cilia显示文摘 | Patel V Li L Cobo-Stark P | 2008 | Hum Mol Genet2008，17，： | 1 |
| 11 | Red blood cell distribution width and the risk of death in middle-aged and older adults显示文摘 | Patel K V Ferrucci L Ershler W B | 2009 | Arch Intern Med2009，169，5： | 1 |
| 12 | A non-hydrostatic threedimensional numerical model for hydraulic flow simulationPart Ⅰ:formulation and verification显示文摘 | Lai Y G Weber L J Patel V C | 2003 | Journal of Hydraulic Engineering ASCE2003，129，3： | 1 |
| 13 | MicroRNAs and fibrosis显示文摘 | Patel V Noureddine L | | 0，，04： | 1 |
| 14 | Is breast MRI helpful in the evaluation of inconclusive mammographic findings显示文摘 | Moy L Elias K Patel V | 2009 | A JR Am J Roentgenol2009，193，4： | 1 |
| 15 | Detecting adverse events for pa- tient safety research: Areview of current methodologies 显示文摘 | Murff H J Patel V L Hripcsak G | 2003 | Joumal of Biomedical Informatics2003，36，12： | 1 |
| 16 | Total synthesis of a functional designer eukaryotic chromosome 显示文摘 | Annaluru N Muller H Mitchell L A Ramalingam S Stracquadanio G Richardson S M Dymond J S Kuang Z Scheifele L Z Cooper E M Cai Y Z Zeller K Agmon N Han J S Hadjithomas M Tullman J Caravelli K Cirelli K Guo Z Y London V Yeluru A Murugan S Kandavelou K Agier N Fischer G Yang K Martin J A Bilgel M Bohutski P Boulier K M Capaldo B J Chang J Charoen K Choi W J Deng P Dicarlo J E Doong J Dunn J Feinberg J I Fernandez C Floria C E Gladowski D Hadidi P Ishizuka I Jabbari J Lau C Y L Lee P A Li S Lin D Linder M E Ling J Liu J Liu J London M Ma H Mao J Mcdade J E Mcmillan A Moore A M Oh W C Ouyang Y Patel R Paul M Paulsen L C Qiu J Rhee A Rubashkin M G Soh I Y Sotuyo N E Srinivas V Suarez A Wong A Wong R Xie W R Xu Y J Yu A T Koszul R Bader J S Boeke J D Chandrasegaran S | 2014 | Science2014，344，6179： | 1 |
| 17 | MicroRNAs and fibrosis 显示文摘 | Patel V Noureddine L | 2012 | Curr OpinNephrol Hypertens2012，21，4： | 1 |
| 18 | Serum antioxidants and inflammation predict red cell distribution width in older women: The Women's Health and Aging Study I显示文摘 | Semba R D Patel K V Ferrueci L | 2010 | Clin Nutr2010，29，4： | 1 |
| 19 | MicroRNAs and fibrosis显示文摘 | Patel V Noureddine L | 2012 | Curr Opin Nephrol Hypertens2012，21，4： | 1 |
| 20 | Large eddy simulation of turbulent open-channel flow with free surface simulated by level set method 显示文摘 | Yue W Lin C L Patel V C | 2005 | Physics of Fluids2005，17，： | 1 |
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