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| 1 | 3D additive manufactured composite scaffolds with antibiotic-loaded lamellar fillers for bone infection prevention and tissue regeneration显示文摘Bone infections following open bone fracture or implant surgery remain a challenge in the orthopedics field.In order to avoid high doses of systemic drug administration,optimized local antibiotic release from scaffolds is required.3D additive manufactured(AM)scaffolds made with biodegradable polymers are ideal to support bone healing in non-union scenarios and can be given antimicrobial properties by the incorporation of antibiotics.In this study,ciprofloxacin and gentamicin intercalated in the interlamellar spaces of magnesium aluminum layered double hydroxides(MgAl)andα-zirconium phosphates(ZrP),respectively,are dispersed within a thermoplastic polymer by melt compounding and subsequently processed via high temperature melt extrusion AM(~190◦C)into 3D scaffolds.The inorganic fillers enable a sustained antibiotics release through the polymer matrix,controlled by antibiotics counterions exchange or pH conditions.Importantly,both antibiotics retain their functionality after the manufacturing process at high temperatures,as verified by their activity against both Gram+and Gram-bacterial strains.Moreover,scaffolds loaded with filler-antibiotic do not impair human mesenchymal stromal cells osteogenic differentiation,allowing matrix mineralization and the expression of relevant osteogenic markers.Overall,these results suggest the possibility of fabricating dual functionality 3D scaffolds via high temperature melt extrusion for bone regeneration and infection prevention. | María C´amara-Torres Stacy Duarte Ravi Sinha Ainhoa Egizabal Noelia´Alvarez Maria Bastianini Michele Sisani Paolo Scopece Marco Scatto Alessandro Bonetto Antonio Marcomini Alberto Sanchez Alessandro Patelli Carlos Mota Lorenzo Moroni | 2021 | Bioactive Materials2021，6，4： | 2 |
| 2 | Serum TSH values and risk of vertebral fractures in euthyrnid post-menopausal women with low bone mineral density显示文摘 | Mazziotti G Porcelli T Patelli I ct al | 2010 | Bone2010，46，3： | 1 |
| 3 | The Missing Link between Corporate Performance Measurement Systems and Chief Executive Officer Incentive Plans显示文摘 | Dossi A Patelli L Zoni L | 2010 | Journal of Accounting Auditing & Finance2010，25，4： | 1 |
| 4 | Feasibility and efficacy of percutaneous transcatheter intraarterial chemotherapy with paclitaxel in albumin nanoparticles for advanced squamous-cell carcinoma of the oral cavity,oropharynx,and hypopharynx 显示文摘 | Damascelli B Patelli G Tichc V | 2007 | J Vasc Interv Radiol2007，18，11： | 1 |
| 5 | Catheter-based radiofrequency renal sympathetic denervation for resistant hypertension显示文摘 | Damascelli B Patelli G Tichá V | | 0，，： | 1 |
| 6 | Optical coherence tomography in idiopathic epiretinal macular membrane surgery显示文摘 | Azzolini C Patelli F Codenotti M | 1999 | Eur J Ophthalmology1999，9，3： | 1 |
| 7 | Use of a retrievable vena cava filter with low-intensity anticoagulation for prevention of pulmonary embolism in patients with cancer:an observational study in 106 cases显示文摘 | Damascelli B Ticha V Patelli G | 2011 | J Vasc Interv Radiol2011，22，： | 1 |
| 8 | Pituitary tumours: inflammatory and granulomatous expansive lesions of the pituitary显示文摘 | Carpinteri R Patelli I Casanueva FF | 2009 | Best Pract Res Clin Endocrinol Metab2009，23，5： | 1 |
| 9 | 25-gauge macular surgery: results and complications显示文摘 | Patelli F Radice P Zumbo G | 2007 | Retina2007，27，6： | 1 |
| 10 | Hypertrophied bronchial artery as a cause of bleeding after transbronchial needle aspiration显示文摘 | Trisolini RB Patelli M | 2012 | Respiration2012，83，1： | 1 |
| 11 | Epidermal growth factor receptor gene copy number KRAS mutation and pathological response to preoperative cetuximab, 5FU and radiation therapy in locally advanced rectal cancer显示文摘 | Bengala C Patelli S Bertolini F | 2009 | Ann Oncol2009，20，2： | 1 |
| 12 | Time course of changes in retinal thickness and visual acuity after intravitreal triameinolone aeetonide for diffuse diabetic maelllar edema with and without previous macular laser treatment显示文摘 | Patelli F Fasolino G Radice P | 2005 | Retina2005，57，25： | 1 |
| 13 | Optical coherencetomography in idiopathic epiretinal macular membrane surgery显示文摘 | Azzolini C Patelli F Codenotti M | 1999 | Eur J ophthalmol1999，9，3： | 1 |
| 14 | 25-gauge macular surgery: results and complications 显示文摘 | Patelli F Radice P Zumbo G Frisone G Fasolino G | 2007 | Retina2007，27，6： | 1 |
| 15 | A 20-year experience with mitral valve repair with artificial chordae in 608 patients显示文摘 | Loris Salvador Salvatore Mirone Roberto Bianchini Tommaso Regesta Fabio Patelli Giuseppe Minniti Mauro Masat Elena Cavarretta Carlo Valfrè | 2008 | The Journal of Thoracic and Cardiovascular Surgery2008，，6： | 1 |
| 16 | An MRI assessment of chronic synovial-based inflammation in gout and its correlation with serum urate levels显示文摘 | Carter J D Patelli M Anderson S R | 2015 | Clinical rheumatology2015，34，2： | 1 |
| 17 | Assessment of the availability of an offshore installation by Monte Carlo simulation显示文摘 | Zio Enrico Baraldi Piero Patelli Edoardo | 2006 | International Journal of Pressure Vessels and Piping2006，83，： | 1 |
| 18 | Optical coherence tomography evaluation of macular edema after radial optic neurotomy in patients affected by central retinal vein occlusion显示文摘 | Patelli F Radice P Zumbo G Fasolino G Marchi S | 2004 | Semin Ophthalmol2004，19，12： | 1 |
| 19 | Placement of long-term central venous catheters in outpatients: Study of 134 patients over 24 596 catheter days 显示文摘 | Damascelli B Patelli G Frigerio LF | 1997 | AJR Am J Roentgenol1997，168，： | 1 |
| 20 | Synthesis and antitumour activity of new daunorubicin and adriamycin analogues显示文摘 | Arcamone F Bernardi L Patelli B | 1978 | Experientia1978，34，： | 1 |
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