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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Tissue differential expression of lycopene β-cyclase gene in papaya显示文摘Carotene pigments in flowers and fruits are distinct features related to fitness advantages such as attracting insects forpollination and birds for seed dispersal.In papaya,the flesh color of the fruit is considered a quality trait that correlateswith nutritional value and is linked to shelf-life of the fruit.To elucidate the carotenoid biosynthesis pathway in papaya,we took a candidate gene approach to clone the lycopene β-cyclase gene,LCY-B.A papaya LCY-B ortholog,cpLCY-B,was successfully identified from both cDNA and bacterial artificial chromosome(BAC)libraries and complete genomicsequence was obtained from the positive BAC including the promoter region.This cpLCY-B shared 80% amino acididentity with citrus LCY-B.However,full genomic sequences from both yellow- and red-fleshed papaya were identical.Quantitative real-time PCR(qPCR)revealed similar levels of expression at six different maturing stages of fruits forboth yellow-and red-fleshed genotypes.Further expression analyses of cpLCY-B showed that its expression levels wereseven- and three-fold higher in leaves and,respectively,flowers than in fruits,suggesting that cpLCY-B is down-regulatedduring the fruit ripening process. | Rachel L Skelton Qingyi Yu Rajeswari Srinivasan Richard Manshardt Paul H Moore Ray Ming | 2006 | Cell Research2006，16，8： | 8 |
| 3 | Diagnostic accuracy of FibroScan and comparison to liver fibrosis biomarkers in chronic viral hepatitis: A multicenter prospective study (the FIBROSTIC study)显示文摘 | Francoise Degos Paul Perez Bruno Roche Amel Mahmoudi Julien Asselineau Hélène Voitot Pierre Bedossa | 2010 | Journal of Hepatology2010，，6： | 3 |
| 4 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 5 | NIR Spectroscopy Applications for Internal and External Quality Analysis of Citrus Fruit—A Review显示文摘 | Lembe S. Magwaza Umezuruike Linus Opara Hélène Nieuwoudt Paul J. R. Cronje Wouter Saeys Bart Nicola? | 2012 | Food and Bioprocess Technology2012，，2： | 2 |
| 6 | DNA vaccination of infants in the presence of maternal antibody: a measles model in the primate显示文摘 | Mary Premenko-Lanier Paul A Rota Gary Rhodes David Verhoeven Dan H Barouch Nicholas W Lerche Norman L Letvin William J Bellini Michael B McChesney | 2003 | Virology2003，，1： | 2 |
| 7 | Clopidogrel for coronary stenting response variability, drug resistance, and the effect of pretreatment platelet reactivity显示文摘 | PAUL A C KEVIN P B BONNIE L H et aI | 2003 | Circulation2003，107，： | 1 |
| 8 | Comparative analysis of four methods to extract DNA from paraffin-embedded tissues:effect on downstream molecular applications显示文摘 | CORNELIS J J JOHANNES C L PAUL H M S | 2010 | BMC Research Notes2010，239，3： | 1 |
| 9 | Multiaspect target detection for SAR imagery using hidden markov models显示文摘 | Paul R Nguyen L H McClellan J H | 2001 | IEEE Trans Geoscience and Remote Sensing2001，39，1： | 1 |
| 10 | The bioaccessibility of lead (Pb) from vacuumed house dust on carpets in urban residences 显示文摘 | Yu C H Yiin L M Paul J L | 2006 | Risk Analysis2006，26，1： | 1 |
| 11 | The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria显示文摘 | Elizabeth MH Wellington Alistair BA Boxall Paul Cross Edward J Feil William H Gaze Peter M Hawkey Ashley S Johnson-Rollings Davey L Jones Nicholas M Lee Wilfred Otten Christopher M Thomas A Prysor Williams | 2013 | The Lancet Infectious Diseases2013，，2： | 1 |
| 12 | Maternal antibody inhibits both cellular and humoral immunity in response to measles vaccination at hirth显示文摘 | Mary P L Gregory H Paul R | 2006 | Virology2006，350，2： | 1 |
| 13 | Experimental validation of a combined electromagnetic and thermal FDTD model of a microwave-heating process 显示文摘 | Ma L H Paul D L Pothecary N | 1995 | IEEE Trans Microwave Theory Tech1995，43，： | 1 |
| 14 | NMDA receptor subtypes: Structure,fimction and theraeutics 显示文摘 | Chaffey H Paul L Chazot | 2008 | Curr Anaesth Critical Care2008，19，： | 1 |
| 15 | Variability estimation of urban wastewater biodegradable fractions by respirometry显示文摘 | Fabienne Lagarde Marie-Hélène Tusseau-Vuillemin Paul Lessard Alain Héduit Fran?ois Dutrop Jean-Marie Mouchel | 2005 | Water Research2005，，19： | 1 |
| 16 | The Spaeefilling Curves with Optimal Partitioning Heuristic for the Vehicle Routing Problem显示文摘 | Robert L B Paul H C | 1994 | European Journal of Operation Research1994，76，： | 1 |
| 17 | A computerized method of visual acuity testing显示文摘 | Roy W Beck Pamela S Moke Andrew H Turpin Frederick L Ferris John Paul SanGiovanni Chris A Johnson Eileen E Birch Danielle L Chandler Terry A Cox R.Clifford Blair Raymond T Kraker | 2003 | American Journal of Ophthalmology2003，，2： | 1 |
| 18 | Plate Tectonics and Basin Subsidence History显示文摘 | Xie X Y Paul L H | | 0，，1： | 1 |
| 19 | Effect of centidepressant medication resistance on short-termresponse to electroconversivetherapy显示文摘 | Walter W Ariejan L Paul G H | 2004 | Psychopharmcology2004，24，9： | 1 |
| 20 | Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study显示文摘 | Ronenn Roubenoff Helen Parise Hélène A Payette Leslie W Abad Ralph D’Agostino Paul F Jacques Peter W.F Wilson Charles A Dinarello Tamara B Harris | 2003 | The American Journal of Medicine2003，，6： | 1 |
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