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| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | 农村人口亚临床动脉粥样硬化及其与冠状动脉疾病危险因素的关系显示文摘在美国〈65岁的人群中,包括无症状的个体在内,每年有超过15万的心血管事件发生。冠状动脉钙化(coronary artery calcium,CAC)是冠状动脉疾病(coronary artery disease,CAD)的亚临床指标,可提高无症状个体的危险分层。该研究旨在评估农村人口的CAC发生率,确定CAD传统危险因素和CAC评分之间的相关性。方法:2011年1月至2012年12月,研究人员对来自阿巴拉契亚中部地区无症状个体的CAC情况进行筛查,根据Agatston钙化评分将受试者分为4种CAC水平:无(CAC=0),轻度(CAC=1~99),中度(CAC=100~399)和重度(CAC≥400)。 | 刘莉 叶鹏 Mamudu HM Paul T Veeranki SP Wang L Panchal HB Budoff M | 2015 | 中华高血压杂志2015，23，8： | 3 |
| 3 | Prospective, randomized trial comparing laparoscopicvs. conventional surgery for refractory ileocolic crohn’s disease显示文摘 | Dr. Jeffrey W. Milson M.D. Katherine A. Hammerhofer R.N. B.S.N. Bartholomaus B?hm M.D. Ph.D. Peter Marcello M.D. Paul Elson Ph.D. Victor W. Fazio M.B. M.S. F.R.A.C.S | 2001 | Diseases of the Colon & Rectum2001，，1： | 1 |
| 4 | Long-term outcome in the north east Melbourne stroke incidence study predictors of quality of life at 5 years after stroke显示文摘 | Paul SL Sturm JW Dewey HM | 2005 | Stroke2005，36，10： | 1 |
| 5 | On the nature of hypertrophytic scars and keloids:A review显示文摘 | Frank B Paul HM Joost S | 1999 | Plast Reconstr Surg1999，104，： | 1 |
| 6 | Ambulatory Blood Pressure Changes After Renal Sympathetic Denervation in Patients With Resistant Hypertension显示文摘 | Felix Mahfoud Christian Ukena Roland E. Schmieder Bodo Cremers Lars C. Rump Oliver Vonend Joachim Weil Martin Schmidt Uta C. Hoppe Thomas Zeller Axel Bauer Christian Ott Erwin Blessing Paul A. Sobotka Henry Krum Markus Schlaich Murray Esler Michael B?hm | 2013 | Circulation2013，，2： | 1 |
| 7 | On the nature of hypertrophic scars and keloids:a review显示文摘 | Frank B Paul HM Joost S | 1999 | Plast Reconstr Surg1999，104，5： | 1 |
| 8 | The Role of Renal Denervation in the Treatment of Heart Failure显示文摘 | Paul A. Sobotka Henry Krum Michael B?hm Darrel P. Francis Markus P. Schlaich | 2012 | Current Cardiology Reports2012，，3： | 1 |
| 9 | Atorvastatin Upregulates Type III Nitric Oxide Synthase in Thrombocytes, Decreases Platelet Activation, and Protects From Cerebral Ischemia in Normocholesterolemic Mice显示文摘 | Ulrich Laufs Karen Gertz Paul Huang Georg Nickenig Michael B?hm Ulrich Dirnagl Matthias Endres | 2000 | Stroke: Journal of the American Heart Association2000，，10： | 1 |
| 10 | Renal Sympathetic Denervation for Treatment of Drug-Resistant Hypertension: One-Year Results From the Symplicity HTN-2 Randomized, Controlled Trial显示文摘 | Murray D. Esler Henry Krum Markus Schlaich Roland E. Schmieder Michael B?hm Paul A. Sobotka | 2012 | Circulation2012，，25： | 1 |
| 11 | Prospective, randomized trial comparing laparoscopic vs. conventional surgery for refractory ileocolic crohn?s disease显示文摘 | Jeffrey W. Milson Katherine A. Hammerhofer Bartholomaus B?hm Peter Marcello Paul Elson Victor W. Fazio | 2001 | Diseases of the Colon & Rectum2001，，： | 1 |
| 12 | Prcvalence of' depression and use of an tidepressant medication at 5-years poststroke in the North East Melbourne Stoke Incidence Study 显示文摘 | Paul SL Dewey HM Sturm JM | 2006 | Stroke2006，37，11： | 1 |
| 13 | Resistin promotes endothelial cell activation:further evidence of adipokine endothelial interaction1显示文摘 | Li MS Chao HM Paul WM | 2003 | Circulation2003，108，6： | 1 |
| 14 | Long-term outcome in the North East Melbourne Stroke Incidence Study:predictors of quality of life at 5 years after stroke显示文摘 | Paul SL Sturm JW Dewey HM | 2005 | Stroke2005，36，： | 1 |
| 15 | 2007 Focused update of the ACC/AHA 2004 guidelines for the manage- ment of patients with st-elevation myocardial infarction: a report of the American college of cardiology/American heart association task force on practice guidelines显示文摘 | Elliott MA Mary HM Paul WA | 2013 | Cir- culation2013，117，2： | 1 |
| 16 | On the nature of hypertrophic scars and keloids: a review显示文摘 | Frank B Paul HM Joost S | 1999 | Plast Reconstr Surg1999，104，5： | 1 |
| 17 | Bone tissue reconstruction using titanium mesh combined with rat bone marrow stromal cells显示文摘 | Van den Dolder J Edward F Paul HM | 2003 | Biomaterials2003，24，： | 1 |
| 18 | Prcvalence of depression and use of an tidepressant medication at 5-years poststroke in the North East Melbourne Stroke Incidence Study显示文摘 | Paul SL Dewey HM Sturm JW | 2006 | Stroke2006，37，11： | 1 |
| 19 | Ambulatory Blood Pressure Changes After Renal Sympathetic Denervation in Patients With Resistant Hypertension显示文摘 | Felix Mahfoud Christian Ukena Roland E. Schmieder Bodo Cremers Lars C. Rump Oliver Vonend Joachim Weil Martin Schmidt Uta C. Hoppe Thomas Zeller Axel Bauer Christian Ott Erwin Blessing Paul A. Sobotka Henry Krum Markus Schlaich Murray Esler Michael B?hm | 2013 | Circulation2013，，2： | 1 |
| 20 | Feasibility of catheter-based renal nerve ablation and effects on sympathetic nerve activity and blood pressure in patients with end-stage renal disease显示文摘 | Markus P. Schlaich Bradley Bart Dagmara Hering Anthony Walton Petra Marusic Felix Mahfoud Michael B?hm Elisabeth A. Lambert Henry Krum Paul A. Sobotka Roland E. Schmieder Carolina Ika-Sari Nina Eikelis Nora Straznicky Gavin W. Lambert Murray D. Esler | 2013 | International Journal of Cardiology2013，，： | 1 |
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