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| 1 | The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease显示文摘 | Marno C. Ryan Catherine Itsiopoulos Tania Thodis Glenn Ward Nicholas Trost Sophie Hofferberth Kerin O’Dea Paul V. Desmond Nathan A. Johnson Andrew M. Wilson | 2013 | Journal of Hepatology2013，，1： | 6 |
| 2 | 老年人处方遗漏筛查工具第2版(中文版)显示文摘近年来我国老年人口数量迅速增加,2013年老年人口突破2亿大关。老年人常伴有多种疾病且同时服用多种药物,容易出现药物相互作用和药物不良反应,所以老年人用药问题是医务人员关注的重点。老年人不适当用药问题主要包括两个方面:老年人需要避免使用的药物和老年人需要使用而未使用的药物。 | Denis O'Mahony David O'Sullivan Stephen Byrne Marie Noelle O'Connor Cristin Ryan Paul Gallagher 侯凯旋 邢晓璇 闫素英 | 2017 | 药物不良反应杂志2017，19，5： | 4 |
| 3 | Alcohol Consumption Decreases Rat Hepatic Creatine Biosynthesis Via Altered Guanidinoacetate Methyltransferase Activity显示文摘 | Kusum K. Kharbanda Sandra L. Todero Jordan C. Moats Ryan M. Harris Natalia A. Osna Paul G. Thomes Dean J. Tuma | 2014 | Alcohol Clin Exp Res2014，，3： | 2 |
| 4 | Is Ulnar Nerve Transposition Beneficial During Open Reduction Internal Fixation of Distal Humerus Fractures?显示文摘 | Ryan C Chen David J Harris Stephane Leduc Joseph J Borrelli Paul Tornetta William M Ricci | 2010 | Journal of Orthopaedic Trauma2010，，7： | 2 |
| 5 | Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically显示文摘 | Tracy L. Putoczki Stefan Thiem Andrea Loving Rita A. Busuttil Nicholas J. Wilson Paul K. Ziegler Paul Nguyen Adele Preaudet Ryan Farid Kirsten Edwards Yeliz Boglev Rodney B. Luwor Andrew Jarnicki David Horst Alex Boussioutas Joan K. Heath Oliver M. Sieber | 2013 | Cancer Cell2013，，： | 2 |
| 6 | Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses显示文摘His-tRNA synthetase (HARS) is targeted by autoantibodies in chronic and acute inflammatory anti-Jo-1-positive antisynthetase syndrome. The extensive activation and migration of immune cells into lung and muscle are associated with interstitial lung disease, myositis, and morbidity. It is unknown whether the sequestration of HARS is an epiphenomenon or plays a causal role in the disease. Here, we show that HARS circulates in healthy individuals, but it is largely undetectable in the serum of anti-Jo-1-positive antisynthetase syndrome patients. In cultured primary human skeletal muscle myoblasts (HSkMC), HARS is released in increasing amounts during their differentiation into myotubes. We further show that HARS regulates immune cell engagement and inhibits CD4+ and CD8+ T-cell activation. In mouse and rodent models of acute inflammatory diseases, HARS administration downregulates immune activation. In contrast, neutralization of extracellular HARS by high-titer antibody responses during tissue injury increases susceptibility to immune attack, similar to what is seen in humans with anti-Jo-1-positive disease. Collectively, these data suggest that extracellular HARS is homeostatic in normal subjects, and its sequestration contributes to the morbidity of the anti-Jo-1-positive antisynthetase syndrome. | Ryan AAdams Cátia Fernandes-Cerqueira Antonella Notarnicola Elisabeth Mertsching Zhiwen Xu Wing-Sze Lo Kathleen Ogilvie Kyle PChiang Jeanette Ampudia Sanna Rosengren Andrea Cubitt David JKing John DMendlein Xiang-Lei Yang Leslie ANangle Ingrid ELundberg Per-Johan Jakobsson Paul Schimmel | 2021 | Cellular & Molecular Immunology2021，18，6： | 2 |
| 7 | A MyD88-dependent IFNyR-CCR2 signaling circuit is required for mobilization of monocytes and host defense against systemic bacterial challenge显示文摘 | Eric M Pietras Lloyd S Miller Carl T Johnson Ryan M O'Connell Paul W Dempsey Genhong Cheng | 2011 | Cell Research2011，21，7： | 2 |
| 8 | IL-4 regulates growth and differentiation by distinct mechanisms显示文摘 | Keegan AD Ryan JJ Paul WE | 1996 | The Immunologist1996，4，： | 1 |
| 9 | THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions显示文摘 | Keats Nelms Achsah D. Keegan José Zamorano John J. Ryan William E. Paul | 1999 | Annual Review of Immunology1999，，： | 1 |
| 10 | Avoiding Seeking Help in the Classroom: Who and Why?显示文摘 | Allison M. Ryan Paul R. Pintrich Carol Midgley | 2001 | Educational Psychology Review2001，，2： | 1 |
| 11 | Statistical methods in developmental toxicology显示文摘 | Paul J Catalano Louise M Ryan | 1994 | Handbook of Statistics1994，，： | 1 |
| 12 | The kinetics and mechanisms of the complex formation and antioxidant behaviour of the polyphenols EGCg and ECG with iron(III)显示文摘 | Paul Ryan Michael J. Hynes | 2006 | Journal of Inorganic Biochemistry2006，，4： | 1 |
| 13 | Nest construction by a ground-nesting bird represents a potential trade-off between egg crypticity and thermoregulation显示文摘 | Paul M. Mayer Levica M. Smith Robert G. Ford Dustin C. Watterson Marshall D. McCutchen Mark R. Ryan | 2009 | Oecologia2009，，4： | 1 |
| 14 | A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen显示文摘 | Xiao-Jun Ma Zuncai Wang Paula D Ryan Steven J Isakoff Anne Barmettler Andrew Fuller Beth Muir Gayatry Mohapatra Ranelle Salunga J.Todd Tuggle Yen Tran Diem Tran Ana Tassin Paul Amon Wilson Wang Wei Wang Edward Enright Kimberly Stecker Eden Estepa-Sabal Ba | 2004 | Cancer Cell2004，，6： | 1 |
| 15 | No increase in the expression of key unfolded protein response genes in HCV genotype 3 patients with severe steatosis显示文摘 | Mario Congiu Marno C. Ryan Paul V. Desmond | 2011 | Virus Research2011，，1： | 1 |
| 16 | Immunocolloidal Targeting of the Endocytotic Siglec-7 Receptor Using Peripheral Attachment of Siglec-7 Antibodies to Poly(Lactide-co-Glycolide) Nanoparticles显示文摘 | Christopher J. Scott Waleed M. Marouf Derek J. Quinn Richard J. Buick Selinda J. Orr Ryan F. Donnelly Paul A. McCarron | 2008 | Pharmaceutical Research2008，，1： | 1 |
| 17 | Apprenticeship in the British 'Training Market' 显示文摘 | Ryan Paul Unwin Loma | 2001 | National Insti- tute Economic Review2001，178，1： | 1 |
| 18 | Traumatic abdominal hernia with presternal herniation显示文摘 | Paul B Sandy W Ryan J | 2009 | Can J Surg2009，52，5： | 1 |
| 19 | The institutional requirements of apprenticeship:evi- dence from smaller EU countries 显示文摘 | Ryan Paul | 2001 | Intemational Journal of Training and Development2001，4，1： | 1 |
| 20 | Programming infant gut microbiota: influence of dietary and environmental factors显示文摘 | Tatiana Milena Marques Rebecca Wall R Paul Ross Gerald F Fitzgerald C Anthony Ryan Catherine Stanton | 2010 | Current Opinion in Biotechnology2010，，2： | 1 |
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