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| 1 | Glucocorticosteroid therapy in inflammatory bowel diseases: From clinical practice to molecular biology显示文摘Inflammatory bowel diseases(IBDs),such as ulcerative colitis and Crohn's disease,are chronic pathologies associated with a deregulated immune response in the intestinal mucosa,and they are triggered by environmental factors in genetically susceptible individuals.Exogenous glucocorticoids(GCs)are widely used as anti-inflammatory therapy in IBDs.In the past,patients with moderate or severe states of inflammation received GCs as a first line therapy with an important effectiveness in terms of reduction of the disease activity and the induction of remission.However,this treatment often results in detrimental side effects.This downside drove the development of second generation GCs and more precise(non-systemic)drugdelivery methods.Recent clinical trials show that most of these new treatments have similar effectiveness to first generation GCs with fewer adverse effects.The remaining challenge in successful treatment of IBDs concerns the refractoriness and dependency that some patients encounter during GCs treatment.A deeper understanding of the molecular mechanisms underlying GC response is key to personalizing drug choice for IBDs patients to optimize their response to treatment.In this review,we examine the clinical characteristics of treatment with GCs,followed by an in depth analysis of the proposed molecular mechanisms involved in its resistance and dependence associated with IBDs.This thorough analysis of current clinical and biomedical literature may help guide physicians in determining a course of treatment for IBDs patients and identifies important areas needing further study. | Karen Dubois-Camacho Payton A Ottum Daniel Franco-Munoz Marjorie De la Fuente Alejandro Torres-Riquelme David Díaz-Jiménez Mauricio Olivares-Morales Gonzalo Astudillo Rodrigo Quera Marcela A Hermoso | 2017 | World Journal of Gastroenterology2017，23，36： | 6 |
| 2 | Estrogen receptor expression in chronic hepatitis C and hepatocellular carcinoma pathogenesis显示文摘AIM To investigate gender-specific liver estrogen receptor(ER) expression in normal subjects and patients with hepatitis C virus(HCV)-related cirrhosis and hepatocellular carcinoma(HCC).METHODS Liver tissues from normal donors and patients diagnosed with HCV-related cirrhosis and HCV-related HCC were obtained from the NIH Liver Tissue and Cell Distribution System. The expression of ER subtypes, ERα and ERβ, were evaluated by Western blotting and real-time RT-PCR. The subcellular distribution of ERα and ERβ was further determined in nuclear and cytoplasmic tissue lysates along with the expression ofinflammatory [activated NF-κB and IκB-kinase(IKK)] and oncogenic(cyclin D1) markers by Western blotting and immunohistochemistry. The expression of ERα and ERβ was correlated with the expression of activated NF-κB, activated IKK and cyclin D1 by Spearman's correlation. RESULTS Both ER subtypes were expressed in normal livers but male livers showed significantly higher expression of ERα than females(P < 0.05). We observed significantly higher m RNA expression of ERα in HCV-related HCC liver tissues as compared to normals(P < 0.05) and ERβ in livers of HCV-related cirrhosis and HCV-related HCC subjects(P < 0.05). At the protein level, there was a significantly higher expression of nuclear ERα in livers of HCV-related HCC patients and nuclear ERβ in HCV-related cirrhosis patients as compared to normals(P < 0.05). Furthermore, we observed a significantly higher expression of phosphorylated NF-κB and cyclin D1 in diseased livers(P < 0.05). There was a positive correlation between the expression of nuclear ER subtypes and nuclear cyclin D1 and a negative correlation between cytoplasmic ER subtypes and cytoplasmic phosphorylated IKK in HCV-related HCC livers. These findings suggest that dysregulated expression of ER subtypes following chronic HCVinfection may contribute to the progression of HCVrelated cirrhosis to HCV-related HCC.CONCLUSION Gender differences were observed in ERα expression in normal livers. Alterations in ER subtype expression observed in diseased livers may influence genderrelated disparity in HCV-related pathogenesis. | Janaki K Iyer Mamta Kalra Anil Kaul Mark E Payton Rashmi Kaul | 2017 | World Journal of Gastroenterology2017，23，37： | 5 |
| 3 | On the formation and growth of intermetallic phases during interdiffusion between low-carbon steel and aluminum alloys显示文摘 | H. Springer A. Kostka E.J. Payton D. Raabe A. Kaysser-Pyzalla G. Eggeler | 2010 | Acta Materialia2010，，4： | 2 |
| 4 | Urinary tract obstruction:optimizing removal of ureteral stents显示文摘 | Payton S | 2011 | Nat Rev Urol2011，8，10： | 1 |
| 5 | Maintenance of meiotic arrest in bovine oocytes using the S-enantiomer of roscovitine:effects on maturation,fertilization and subsequent embryo development in vitro显示文摘 | Coy P Romar R Payton R R | | 0，，01： | 1 |
| 6 | Enhanced photochemical light utilization and decreased chilling induced photo inhibition of photosystem Ⅱ in cotton over expressing genes encoding chloroplast-targeted anti oxidant enzymes显示文摘 | Komyeyev D Logan BA Payton P | | 0，，： | 1 |
| 7 | Induction of tumorigen-esis and metastasis by the murine orthologue of tumor protein D52 显示文摘 | Lewis J D Payton L A Whitford J G | 2007 | Mol Cancer Res2007，5，2： | 1 |
| 8 | Privacy of Medical Re-cords :IT implications of HIPAA 显示文摘 | Baumer D Earp J B Payton F C | 2000 | ACM SIGCAS Com-puters and Society2000，30，4： | 1 |
| 9 | Influence of place attachment and trust on civic action: a study at Sherburne National Wildlife Refuge显示文摘 | Payton M A Fulton D C Anderson D H | 2005 | Society & Natural Resources2005，18，6： | 1 |
| 10 | Fractal dimension and lacunarity determined with X-ray computed tomography 显示文摘 | Gantzer C J Payton R L | 1996 | Soil Sci Soc Am J1996，60，： | 1 |
| 11 | The COOH terminus of arylamine N-acetyltransferase from Salmonella typhimurium controls enzymic activity显示文摘 | Mushtaq A Payton M Sim E | 2002 | J Biol Chem2002，277，12： | 1 |
| 12 | Acute ischemic stroke and hyperglyeemia显示文摘 | Clark ME Payton JE Pittiglio LI | 2014 | Crit Care Nurs Q2014，37，18： | 1 |
| 13 | Combined surgical approach to esthesioneuro- epithelioma显示文摘 | Doyle P Payton H | 1971 | Trans Pa Acad Opbthalmol Otolaryngol1971，75，： | 1 |
| 14 | On the formation andgrowth of intermetallic phases during interdiffusion betweenlow-carbon steel and aluminum alloys 显示文摘 | SPRINGER H KOSTKA A PAYTON E J RAABE D KAYSSER-PYZALLA A EGGELER G | 2011 | Acta Materialia2011，59，4： | 1 |
| 15 | Discovery and evaluation of dual CDK1 and CDK2 inhibitors显示文摘 | Chung G Yakowec P | 2006 | Mol Cancer Ther2006，5，3： | 1 |
| 16 | Material recovery and re-use technologies for the paper industry显示文摘 | Phipps J S Skuse D R Payton D C | 1999 | Paper Technology1999，40，1： | 1 |
| 17 | Multiple bumps seen on the heels 显示文摘 | Payton L | 2007 | JAAPA2007，20，7： | 1 |
| 18 | Induction of tumorigen- esis and metastasis by the murine orthologue of tumor protein D52 显示文摘 | Lewis J D Payton L A Whitford J G | 2007 | Mol Cancer Res2007，5，2： | 1 |
| 19 | ESTs, cDNA microarrays, and gene expression profiling: tools for dissecting plant physiology and development 显示文摘 | ALBA R FEI Z PAYTON P | 2004 | Plant J2004，39，： | 1 |
| 20 | Round bale silage storage losses of ryegrass and legume-grass forages显示文摘 | Huhnke R L Muck R E Payton M E | 1997 | Applied Engineering in Agriculture1997，13，4： | 1 |
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