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| 1 | Impaired swallowing mechanics of post radiation therapy head and neck cancer patients: A retrospective videofluoroscopic study显示文摘AIM: To determine swallowing outcomes and hyolaryngeal mechanics associated with post radiation therapy head and neck cancer(rt HNC) patients using videofluoroscopic swallow studies. METHODS: In this retrospective cohort study, video-fluoroscopic images of rt HNC patients(n = 21) were compared with age and gender matched controls(n = 21). Penetration-aspiration of the bolus and bolus residue were measured as swallowing outcome variables. Timing and displacement measurements of the anterior and posterior muscular slings elevating the hyolaryngeal complex were acquired. Coordinate data of anatomical landmarks mapping the action of the anterior muscles(suprahyoid muscles) and posterior muscles(long pharyngeal muscles) were used to calculate the distance measurements, and slice numbers were used to calculate time intervals. Canonical variate analysis with post-hoc discriminant function analysis was performed on coordinate data to determine multivariate mechanics of swallowing associated with treatment. Pharyngeal constriction ratio(PCR) was also measured to determine if weak pharyngeal constriction is associated with post radiation therapy.RESULTS: The rt HNC group was characterized by poor swallowing outcomes compared to the control group in regards to: Penetration-aspiration scale(P < 0.0001), normalized residue ratio scale(NRRS) for the valleculae(P = 0.002) and NRRS for the piriform sinuses(P = 0.003). Timing and distance measurements of the anterior muscular sling were not significantly different in the two groups, whereas for the PMS time of displacement was abbreviated(P = 0.002) and distance of excursion was reduced(P = 0.02) in the rt HNC group. A canonical variate analysis shows a significant reduction in pharyngeal mechanics in the rt HNC group(P < 0.0001). The PCR was significantly higher in the test group than the control group(P = 0.0001) indicating reduced efficiency in pharyngeal clearance. CONCLUSION: Using videofluoroscopy, this study shows rt HNC patients have worse swallowing outcomes associated with reduced hyolaryngeal mechanics and pharyngeal constriction compared with controls. | William G Pearson Jr Alisa A Davidoff Zachary M Smith Dorothy E Adams Susan E Langmore | 2016 | World Journal of Radiology2016，8，2： | 2 |
| 2 | NOD2 and ATG16L1 polymorphisms affect monocyte responses in Crohn's disease显示文摘AIM:To assess whether polymorphisms in NOD2 and ATG16L1 affect cytokine responses and mycobacterium avium subspecies paratuberculosis (MAP) survival in monocytes from Crohn's disease (CD) patients.METHODS:Monocytes were isolated from peripheral blood of CD patients of known genotype for common single nucleotide polymorphisms of NOD2 and ATG16L1.Monocytes were challenged with MAP and bacterial persistence assessed at subsequent time-points.Cytokine responses were assayed using a Milliplex multi-analyte profiling assay for 13 cytokines.RESULTS:Monocytes heterozygous for a NOD2 polymorphism (R702W,P268S,or 1007fs) were more permissive for growth of MAP (P=0.045) than those without.There was no effect of NOD2 genotype on subsequent cytokine expression.The T300A polymorphism ofATG16L1 did not affect growth of MAP in our model (P=0.175),but did increase expression of cytokines interleukin (IL)-10 (P=0.047) and IL-6 (P=0.019).CONCLUSION:CD-associated polymorphisms affected the elimination of MAP fromex vivo monocytes (NOD2),or expression of certain cytokines (ATG16L1),implying independent but contributory roles in the pathogenesis of CD. | Dylan M Glubb Richard B Gearry Murray L Barclay Rebecca L Roberts John Pearson Jacqui I Keenan Judy McKenzie Robert W Bentley | 2011 | World Journal of Gastroenterology2011，17，23： | 2 |
| 3 | Evidence for two rhabdoviruses in taro ( Colocasia esculenta) in the Pacific region显示文摘 | Pearson M N Jackson G V H Saelea J | 1999 | Austral Plant Pathol1999，28，3： | 2 |
| 4 | Active control of helicopter vibration 显示文摘 | Pearson J T Goodall R M Lyndon I | 1994 | Computing & Control Engineering Journal1994，5，6： | 1 |
| 5 | Concrete penetration by eroding projectiles: experiments and analysis 显示文摘 | Gold V M Vrasis G C Pearson J C | 1996 | Journal of Engineering Mechanics1996，122，2： | 1 |
| 6 | -MSH inhibits inflammatory signaling in Schwann cells显示文摘 | Teare Katrina A Pearson Richard G Shakesheff Kevin M | 2004 | NeuroReport2004，15，3： | 1 |
| 7 | The role of the purchasing function: toward team participation显示文摘 | Pearson J N | 1994 | International Journal of Distribution of Purchasing a nd Materials Management1994，29，3： | 1 |
| 8 | Potential of somatic cell concentration in milk as a sire selection criterion to reduce mastitis in dairy cattle 显示文摘 | Coffey E M Vinson W E Pearson R E | 1986 | J Dairy Sci1986，69，： | 1 |
| 9 | 显示文摘 | Bellows DS Howell M Pearson C | 2002 | J Virol2002，76，5： | 1 |
| 10 | Natural gas hydrate deposits: a review of in-situ properties显示文摘 | Pearson C F Halleck P M McGuire P L | 1983 | Journal of geophysical research1983，87，： | 1 |
| 11 | Detection of pollution effects on marine macrobenthos further evaluation of the species abundance biomass method显示文摘 | WARWICK R M PEARSON T H ROSWAHYUMI | 1987 | Marine Biology1987，95，： | 1 |
| 12 | Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients 显示文摘 | Lamont J M McManamy C S Pearson A D | 2004 | Clin Cancer Res2004，10，： | 1 |
| 13 | A phase I study of docetaxel as a radio-sensitizer for locally advanced squamous cell cervical cancer显示文摘 | Alvarez E A Wolfson A H Pearson J M | 2009 | Gynecol Oncol2009，113，2： | 1 |
| 14 | Role of a doxorubi- cin-containing regimen in relapsed and resistant lymphomas: an 8-year follow-up study of EPOCH 显示文摘 | Gutierrez M Chabner BA Pearson D | 2000 | J CIin Oncol2000，18，21： | 1 |
| 15 | The Janus Face of Business Associations in China: Socialist Corporatism in Foreign Enterprises 显示文摘 | PEARSON M M | 1994 | The Australian Journal of Chinese Affairs1994，31，： | 1 |
| 16 | Predicting species distributions from small numbers of occurrence re- cords:A test case using cryptic geckos in Madagascar 显示文摘 | Pearson R G Raxworthy C J Nakamura M | 2007 | Journal of Biogeography2007，34，1： | 1 |
| 17 | Oil distribution in fried potatoes monitored by infrared microspectroscopy显示文摘 | Bouchon P Hollins P Pearson M | 2001 | Journal of Food Science2001，66，7： | 1 |
| 18 | Phrenic nerve neurotization utilizing the spinal accessory nerve:technical note with potential application in patients with high cervical quadriplegia显示文摘 | Tubbs RS Pearson B Loukas M | 2008 | Childs Nerv Syst2008，24，11： | 1 |
| 19 | The involvement of cell-to-cell signals in the development of a bacterial biofilm显示文摘 | DAVIES D G PARSEK M R PEARSON J P | 1998 | Science1998，280，5361： | 1 |
| 20 | Transform coding of images using interleaved blocks 显示文摘 | Pearson D E Whybray M W | 1984 | Communications Radar and Signal Processing of IEE Proceedings1984，131，5： | 1 |
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