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| 1 | CD4+ T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C virus-coinfected patients显示文摘AIM To characterize peripheral blood natural killer(NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus(HIV)/hepatitis C virus(HCV) coinfected patients.METHODS Peripheral mononuclear cells from 24 HIV/HCV(HBVnegative) coinfected and 5 HIV/HCV/HBV seronegative individuals were evaluated. HIV/HCV coinfected patients were divided in to groups: G1, patients with METAVIR F0-F2 and G2, patients with METAVIR F3-F4. NK surface cell staining was performed with: AntiCD3(APC/Cy7), anti-CD56(PE/Cy5), anti-CD57(APC), anti-CD25(PE), anti-CD69(FITC), anti-NKp30(PE), antiNKp46(PE/Cy7), anti-NKG2D(APC), anti-DNAM(FITC); anti-CD62L(PE/Cy7), anti-CCR7(PE), anti-TRAIL(PE), anti-Fas L(PE), anti CD94(FITC). Flow cytometry data acquisition was performed on BD FACSCanto, analyzed using Flow Jo software. Frequency of fluorescence was analyzed for all single markers. Clinical records were reviewed, and epidemiological and clinical data were obtained.RESULTS Samples from 11 patients were included in G1 and from 13 in G2. All patients were on ARV, with undetectable HIV viral load. Liver fibrosis was evaluated by transient elastography in 90% of the patients and with biopsy in 10% of the patients. Mean HCV viral load was(6.18 ± 0.7 log10). Even though, no major significant differences were observed between G1 and G2 regarding NK surface markers, it was found that patients with higher liver fibrosis presented statistically lower percentage of NK cells than individual with low to mild fibrosis and healthy controls(G2: 5.4% ± 2.3%, G1: 12.6% ± 8.2%, P = 0.002 and healthy controls 12.2% ± 2.7%, P = 0.008). It was also found that individuals with higher liver fibrosis presented lower CD4 LT count than those from G1(G2: 521 ± 312 cells/μL, G1: 770 ± 205 cells/μL; P = 0.035).CONCLUSION Higher levels of liver fibrosis were associated with lower percentage of NK cells and LTCD4+ count; and they may serve as noninvasive biomarkers of liver damage. | Natalia Laufer Diego Ojeda María Laura Polo Ana Martinez Héctor Pérez Gabriela Turk Pedro Cahn Norberto Walter Zwirner Jorge Quarleri | 2017 | World Journal of Hepatology2017，9，25： | 2 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Commercialization of transgenic plants potential ecological risks显示文摘 | SNOW A A PEDRO M P | 1997 | Bioscience1997，47，： | 1 |
| 4 | Gpu based real- lime inslrument tracking with three-dimensional ultrasound显示文摘 | Novotny P M Stoll J A Pedro E Nido J D | 2007 | Medical Image Analysis2007，11，5： | 1 |
| 5 | An expeditious method for the determination of organochlorine pesticides residues in estuarine sediments using microwave assisted pre-extraction and automated headspace solid-phase microextraction coupled to gas chromatography-mass spectrometry 显示文摘 | Pedro N C Pedro N R Filipe A Rafael E Maria C P Teresa M V | 2008 | Talanta2008，76，5： | 1 |
| 6 | 查看详情显示文摘 | Pedro A P Nascenie | | 0，，： | 1 |
| 7 | Determination of shelf-life of homogenized apple-based beikost storage at different temperatures using Weibull hazard model显示文摘 | Palazón M A Pérez-Conesa D Pedro A | 2009 | LWT-Food Science and Technology2009，42，1： | 1 |
| 8 | Osteoinduc- tion in human fat-derived stem cells by recombinant human bone morphogenetic protein-2 produced in Escherichia coli 显示文摘 | BESSA P C PEDRO A J KLOSCH B | 2008 | Biotechnol Lett2008，30，1： | 1 |
| 9 | Effects of biosolarization as methylbromide alternative for Meloidogynei ncognitacontrol on quality of soil underpepper显示文摘 | Margarita R Pedro F P Jose A | 2008 | Biology and Fertility of Soils2008，45，1： | 1 |
| 10 | Bronchial artery ebmolization in the management of hemotysis:technical aspects and long term results显示文摘 | Uflacker R Kaemmer A Pedro D P | 1985 | Radiology1985，157，： | 1 |
| 11 | Brugada Phenocopy: New Terminology and Proposed Classification显示文摘 | Adrian Baranchuk Timothy Nguyen Min Hyung Ryu Francisco Femenía Wojciech Zareba Arthur A.M. Wilde Wataru Shimizu Pedro Brugada Andrés R. Pérez‐Riera | 2012 | Annals of Noninvasive Electrocardiology2012，，4： | 1 |
| 12 | Acute and chronic hemodynamic changes after propranolol in patients with cirrhosis under primary and secondary prophylaxis of variceal bleeding: a pilot study显示文摘 | Enrique de-Madaria José María Palazón Flavia Tamara Hernández José Sánchez-Paya Pedro Zapater Javier Irurzun Francisco de Espa?a Sonia Pascual José Such Laura Sempere Fernando Carnicer Antonio García-Herola Jaime Valverde Miguel Pérez-Mateo | 2010 | European Journal of Gastroenterology & Hepatology2010，，5： | 1 |
| 13 | Fatty acid esters of triterpenes from Erythroxylum passerinum显示文摘 | MARIZETH L B JORGE M D PEDRO A P P | 2002 | J Braz Chem Soc2002，13，5： | 1 |
| 14 | Effects of biosolarization as methyl bromide alternative for Meloidogyne incognita control on quality of soil under pepper显示文摘 | Margarita R Pedro F P Jose A | 2008 | Biology and Fertility of Soils2008，45，1： | 1 |
| 15 | SEROPREVALENCE OF HUMAN TOXOCARIASIS IN ANDEAN COMMUNITIES FROM THE NORTHEAST OF LIMA, PERU显示文摘 | Espinoza Yrma A Huapaya Pedro E Roldán William H Jiménez Susana Abanto Enma P Rojas Carlos A Cavero Yuri A Gutiérrez César A | 2010 | Revista do Instituto de Medicina Tropical de S茫o Paulo2010，，1： | 1 |
| 16 | Lignans and a neolignan from Virola oleifera leaves显示文摘 | Anna Maria A P F Lauro E S B Pedro H F | 1993 | Phytochemistry1993，32，6： | 1 |
| 17 | Peptidoglycan struc- ture of Salmonella typhimurium growing within cultured mammalian cells 显示文摘 | Quintela J C de Pedro M A Zollner P | 1997 | Mol Microbiol1997，23，4： | 1 |
| 18 | Synthesis and characterization of hyperbranched alkyd resins based on tall oil fatty acids显示文摘 | EDWIN A MURILLO PEDRO P | | 0，，： | 1 |
| 19 | Cavernomas in children with brain tumors: a late complication of radiotherapy 显示文摘 | Martínez-Lage J F de la Fuente I Ros de San Pedro J Fuster J L Pérez-Espejo M A Herrero M T | 2008 | Neurocirugia (Astur)2008，19，： | 1 |
| 20 | Design,synthesis and application of fluorescent 2,1,3-benzothiadiazole-triazole-linked biologically active lapachone derivatives显示文摘 | DA CRUZ EDUARDO H G CARVALHO PEDRO H P R CORRêA JOSéR | 2014 | New J Chem2014，38，： | 1 |
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