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| 1 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 2 | OsSRK1,an Atypical S-Receptor-Like Kinase Positively Regulates Leaf Width and Salt Tolerance in Rice显示文摘Receptor-like kinases(RLKs)are important for plant growth,development and defense responses.The S-receptor protein kinases(SRKs),which represent an RLK subfamily,control the selfincompatibility among Brassica species.However,little information is available regarding SRK functions in rice.We identified a gene OsSRK1 encoding an atypical SRK.The transcript of OsSRK1 was induced by abscisic acid(ABA),salt and polyethylene glycol.OsSRK1 localized to the plasma membrane and cytoplasm.Leaf width was increased in OsSRK1-overexpression(OsSRK1-OX)transgenic rice plants,likely because of an increase in cell number per leaf.Furthermore,the expression levels of OsCYCA3-1 and OsCYCD2-1,which encode positive regulators of cell division,were up-regulated in leaf primordium of OsSRK1-OX rice plants relative to those in wild type.Meanwhile,the expression level of OsKRP1,which encodes cell cycle inhibitor,was down-regulated in the OsSRK1-OX plants.Therefore,it is deduced that OsSRK1 regulates leaf width by promoting cell division in the leaf primordium.Additionally,OsSRK1-OX plants exhibited enhanced ABA sensitivity and salt tolerance compared with wild type.These results suggest that OsSRK1 plays important roles in leaf development and salt responses in rice. | ZHOU Jinjun JU Peina ZHANG Fang ZHENG Chongke BAI Bo LI Yaping WANG Haifeng CHEN Fan XIE Xianzhi | 2020 | Rice science2020，27，2： | 2 |
| 3 | A chromosome-level genome assembly reveals that a bipartite gene cluster formed via an inverted duplication controls monoterpenoid biosynthesis in Schizonepeta tenuifolia显示文摘Biosynthetic gene clusters(BGCs)are regions of a genome where genes involved in a biosynthetic pathway are in proximity.The origin and evolution of plant BGCs as well as their role in specialized metabolism remain largely unclear.In this study,we have assembled a chromosome-scale genome of Japanese catnip(Schizonepeta tenuifolia)and discovered a BGC that contains multiple copies of genes involved in four adjacent steps in the biosynthesis of p-menthane monoterpenoids.This BGC has an unprecedented bipartite structure,with mirrored biosynthetic regions separated by 260 kilobases.This bipartite BGC includes identical copies of a gene encoding an old yellow enzyme,a type of flavin-dependent reductase.In vitro assays and virus-induced gene silencing revealed that this gene encodes the missing isopiperitenone reductase.This enzyme evolved from a completely different enzyme family to isopiperitenone reductase from closely related Mentha spp.,indicating convergent evolution of this pathway step.Phylogenomic analysis revealed that this bipartite BGC has emerged uniquely in the S.tenuifolia lineage and through insertion of pathway genes into a region rich in monoterpene synthases.The cluster gained its bipartite structure via an inverted duplication.The discovered bipartite BGC for p-menthane biosynthesis in S.tenuifolia has similarities to the recently described duplicated p-menthane biosynthesis gene pairs in the Mentha longifolia genome,providing an example of the convergent evolution of gene order.This work expands our understanding of plant BGCs with respect to both form and evolution,and highlights the power of BGCs for gene discovery in plant biosynthetic pathways. | Chanchan Liu Samuel J.Smit Jingjie Dang Peina Zhou Grant T.Godden Zheng Jiang Wukun Liu Licheng Liui Wei Lin Jinao Duan Qinan Wu Benjamin R.Lichman | 2023 | Molecular Plant2023，16，3： | 2 |
| 4 | Template-directed synthesis of nitrogen- and sulfur- codoped carbon nanowire aerogels with enhanced electrocatalytic performance for oxygen reduction显示文摘做的 Heteroatom,精确作文控制,和合理形态学设计是为在燃料房间为氧减小反应(ORR ) 生产新奇 nanocatalysts 的有效策略。此处,综合的一条划算的途径用一个难 templating 方法的 nitrogen-codoped 和 sulfur-codoped 碳 nanowire aerogels 被建议。aerogels 在碱的答案为 ORR 用热水的处理和碳化展览的联合准备了好催化活动。在在氮和硫先锋之间的最佳的退火温度和集体比率,结果的 aerogels 表演可比较的 electrocatalytic 活动到为 ORR 的商业 Pt/C 催化剂的。重要地,优化催化剂为甲醇转线路效果显示出更好长期的稳定性和令人满意的忍耐。这些 codoped aerogels 被期望在燃料房间有潜在的应用。 | Shaofang Fu Chengzhou Zhu Junhua Song Mark H. Engelhard Xiaolin Li Peina Zhang Haibing Xia Dan Du Yuehe Lin | 2017 | Nano Research2017，10，6： | 1 |
| 5 | A multivariate kolmogorov-Smirnov test of goodness of fit显示文摘 | JUSTEL A PEINA D ZAMAR R | 1997 | Statistics&Probability Letters1997，，35： | 1 |
| 6 | Inhibition effect of secondary metabolites accumulated in a pervaporation membrane bioreactor on ethanol fermentation of Saccharomyces cerevisiae显示文摘 | Senqing Fan Zeyi Xiao Xiaoyu Tang Chunyan Chen Yan Zhang Qing Deng Peina Yao Weijia Li | 2014 | Bioresource Technology2014，，： | 1 |
| 7 | Effect ofphosphorus on biodiesel production from Scenedesmusobliquus under nitrogen-deficiency stress 显示文摘 | Chu Feifei Chu Peina Shen Xiaofei | 2014 | Bioresource Technology2014，152，： | 1 |
| 8 | Phosphorus playsan important role in enhancing biodiesel productivity ofChlorella vulgaris under nitrogen deficiency 显示文摘 | Chu Feifei Chu Peina Cai Peijie | 2013 | Bioresource Technology2013，134，： | 1 |
| 9 | Dose finding study of oral PSC 833 combined with weekly intravenous etoposide in children with relapsed or refractory solid tumours显示文摘 | Peina F Pinkertonb R Berthaudc P | 2007 | Eur J Cancer2007，43，14： | 1 |
| 10 | An im- proved Bayesian structural EM algorithm for learning Bayesian networks for clustering 显示文摘 | PEINA J M LOZANO J A LARRAENAGA P | 2000 | Pattern Recognition Letters2000，21，： | 1 |
| 11 | A Model for Electrochemical Proton-transfer Reactions显示文摘 | Schmickler W | 1998 | Chemical Physics1998，228，： | 1 |
| 12 | Discovery and clinical applica- tions of bone morphogenetic proteins 显示文摘 | Vukicevi S Stavljeni A Peina M | 1995 | Eur J Clin Chem Clin Biechem1995，33，10： | 1 |
| 13 | Conductive PS inverse opals for regulating proliferation and differentiation of neural stem cells显示文摘The development of neural tissue engineering has brought new hope to the treatment of spinal cord injury(SCI).Up to date,various scaffolds have been developed to induce the oriented growth and arrangement of nerves to facilitate the repair after injury.In this work,a conductive and anisotropic inverse opal substrate was presented by modifying polystyrene(PS)inverse opal films with carbon nanotubes and then stretching them to varying degrees.The film had good biocompatibility,and neural stem cells(NSCs)grown on the film displayed good orientation along the stretching direction.In addition,benefiting from the conductivity and anisotropy of the film,NSCs differentiated into neurons significantly.These results suggest that the conductive and anisotropic PS inverse opal substrates possess value in nerve tissue engineering regeneration. | Yangnan Hu Han Zhang Hao Wei Menghui Liao Xiaoyan Chen Jiayue Xing Lian Duan Cuntu Cheng Weicheng Lu Xuechun Yang Peina Wu Huan Wang Jingdun Xie Renjie Chai | 2023 | Engineered Regeneration2023，4，2： | 0 |
| 14 | Ferrodifferentiation regulates neurodevelopment via ROS generation显示文摘Iron is important for life,and iron deficiency impairs development,but whether the iron level regulates neural differentiation remains elusive.In this study,with iron-regulatory proteins(IRPs)knockout embryonic stem cells(ESCs)that showed severe iron deficiency,we found that the Pax6-and Sox2-positive neuronal precursor cells and Tuj1 fibers in IRP1^(-/-)IRP2^(-/-)ESCs were significantly decreased after inducing neural differentiation.Consistently,in vivo study showed that the knockdown of IRP1 in IRP2^(-/-)fetal mice remarkably affected the differentiation of neuronal precursors and the migration of neurons.These findings suggest that low intracellular iron status significantly inhibits neurodifferentiation.When supplementing IRP1^(-/-)IRP2^(-/-)ESCs with iron,these ESCs could differentiate normally.Further investigations revealed that the underlying mechanism was associated with an increase in reactive oxygen species(ROS)production caused by the substantially low level of iron and the downregulation of iron-sulfur cluster protein ISCU,which,in turn,affected the proliferation and differentiation of stem cells.Thus,the appropriate amount of iron is crucial for maintaining normal neural differentiation that is termed ferrodifferentiation. | Shiyang Chang Peina Wang Yingying Han Qiang Ma Zeyuan Liu Suijuan Zhong Yufeng Lu Ruiguo Chen Le Sun Qian Wu Guofen Gao Xiaoqun Wang Yan-Zhong Chang | 2023 | Science China(Life Sciences)2023，66，8： | 0 |
| 15 | Improving hard metal implant and soft tissue integration by modulating the“inflammatory-fibrous complex”response显示文摘Soft tissue integration is one major difficulty in the wide applications of metal materials in soft tissue-related areas.The inevitable inflammatory response and subsequent fibrous reaction toward the metal implant is one key response for metal implant-soft tissue integration.It is of great importance to modulate this inflammatory-fibrous response,which is mainly mediated by the multidirectional interaction between fibroblasts and macrophages.In this study,macrophages are induced to generate M1 and M2 macrophage immune microenvironments.Their cytokine profiles have been proven to have potentially multi-regulatory effects on fibroblasts.The multi-reparative effects of soft tissue cells(human gingival fibroblasts)cultured on metal material(titanium alloy disks)in M1 and M2 immune microenvironments are then dissected.Fibroblasts in the M1 immune microenvironment tend to aggravate the inflammatory response in a pro-inflammatory positive feedback loop,while M2 immune microenvironment enhances multiple functions of fibroblasts in soft tissue integration,including soft tissue regeneration,cell adhesion on materials,and contraction to immobilize soft tissue.Enlighted by the close interaction between macrophages and fibroblasts,we propose the concept of an“inflammatory-fibrous complex”to disclose possible methods of precisely and effectively modulating inflammatory and fibrous responses,thus advancing the development of metal soft tissue materials. | Peina Huang Jieyun Xu Lv Xie Guangqi Gao Shoucheng Chen Zhuohong Gong Xiaomei Lao Zhengjie Shan Jiamin Shi Zhaocai Zhou Zhuofan Chen Yang Cao Yan Wang Zetao Chen | 2023 | Bioactive Materials2023，，2： | 0 |
| 16 | 陈惇(英文)显示文摘Born on 21st,Sep.1934,Dun Chen came from Huchou City,Zhejiang province.He was admitted into Beijing Normal University in 1952.In March 1956,he graduated from the university ahead of time and stayed there as a teacher | Peina ZHUANG | 2015 | Comparative Literature:East & West2015，，2： | 0 |
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