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| 1 | Apelin-13 as a novel target for intervention in secondary injury after traumatic brain injury显示文摘The adipocytokine,apelin-13,is an abundantly expressed peptide in the nervous system.Apelin-13 protects the brain against ischemia/reperfusion injury and attenuates traumatic brain injury by suppressing autophagy.However,secondary apelin-13 effects on traumatic brain injury-induced neural cell death and blood-brain barrier integrity are still not clear.Here,we found that apelin-13 significantly decreases cerebral water content,mitigates blood-brain barrier destruction,reduces aquaporin-4 expression,diminishes caspase-3 and Bax expression in the cerebral cortex and hippocampus,and reduces apoptosis.These results show that apelin-13 attenuates secondary injury after traumatic brain injury and exerts a neuroprotective effect. | Hai-jun Bao Hai-yang Qiu Jin-xia Kuai Cheng-jie Song Shao-xian Wang Chao-qun Wang Hua-bin Peng Wen-can Han Yong-ping Wu | 2016 | Neural Regeneration Research2016，11，7： | 5 |
| 2 | Lamin-like Proteins Negatively Regulate Plant Immunity through NAC WITH TRANSMEMBRANE MOTIF1-LIKE9 and NONEXPRESSOR OF PR 3ENES1 in Arabidopsis thaliana显示文摘 | Tongtong Guo Xuegao Mao Hui Zhang Yu Zhang Mengdi Fu Zhenfei Sun Peng Kuai Yonggen Lou Yuda Fang | 2017 | Molecular Plant2017，10，10： | 3 |
| 3 | Study of preferred background luminance in watching computer screen in children显示文摘 | Shen Yang Kuai Shuguang Zhou Weixi Peng Sheng Tian Mi Liu Kangjun Zhou Xingtao | 2014 | Chinese Medical Journal2014，，11： | 1 |
| 4 | Detail correction for Gross classification of esophageal atresia based on 434 cases in China显示文摘To the Editor:Esophageal atresia(EA)is the most common congenital abnormality of the esophagus.In 70%to 90%of those born with EA,a tracheoesophageal fistula(TEF)co-occurs.Since Vogt[1]recognized and classified the types of anomalies in 1929,many other classification systems have been proposed,including the Ladd,Gross,Swenson,and Kluth classification systems.[2]However,the Gross classification of anatomical patterns of EA/TEF proposed in 1953 is one of the most widely accepted and used classification systems[3]and has been cited in Pediatric Surgery.[4]While surgical and imaging techniques have evolved considerably over recent decades,434 consecutive cases of EA/TEF in China were reviewed.Through closely examining the imaging studies and the pathoanatomical configurations of these patients,we identified certain'defects'and details in the illustrations that need modification. | Shen Yang Ruizhe Yang Xiaofan Ma Shuangfeng Yang Yun Peng Qiang Tao Kuai Chen Junfeng Tao Yanan Zhang Jingbin Du Jinshi Huang Xiaoxia Peng | 2022 | Chinese Medical Journal2022，，4： | 1 |
| 5 | Crystal structures of RNA-dependent RNA polymerases from Jingmen tick virus and Alongshan virus显示文摘Jingmenviruses are a group of flavi-like viruses with segmented genome and have been found in various types of hosts,including humans,cattle,monkeys,bats,rodents,sheep,ticks,mosquitoes and nematodes.Jingmenviruses,including the Jingmen tick virus(JMTV)and Alongshan virus(ALSV),have been associated with febrile illness and flu-like symptoms in humans.Viral polymerase plays critical roles in genome replication and transcription and is an ideal target for antiviral drugs.Here,we determined the crystal structures of RNA-dependent RNA polymerase(RdRp)domains of JMTV and ALSV at 2.6Åand 3.2Åresolutions,respectively.The overall structures of JMTV and ALSV RdRp domains are similar to those from the typical unsegmented viruses in Flaviviridae family,especially the Flavivirus genus.JMTV and ALSV RdRps can be divided into three subdomains and the catalytical Motif A-G are conserved like the typical flaviviruses,whereas the zinc-binding pockets are absent from the JMTV and ALSV RdRps.The 50-ends of jingmenvirus genomes are varied in length and sequence,and a highly conserved 8-nucleotide element located on the tip of stem loop A was identified and shown to be required for binding with RdRp and performing de novo replication activity.These findings provide important structural insights into RdRp of segmented flavivirus and reveal the key region of virus genome responsible for replication initiation,which would promote molecular understanding of segmented flavivirus replication and the structure-based design of antiviral drugs against flaviviruses. | Zhenyang Liu Qi Peng Pu Han Lu Kuai Jianxun Qi Yi Shi | 2024 | hLife2024，2，1： | 0 |
| 6 | Lung imaging characteristics in a patient infected with Elizabethkingia miricola following cerebral hemorrhage surgery: A case report显示文摘BACKGROUND Elizabethkingia miricola is a non-fermenting gram-negative bacterium,which was first isolated from the condensate of the Russian peace space station in 2003.Most studies on this bacterium have been carried out in the laboratory,and clinical case studies are rare.To date,a total of 6 clinical cases have been reported worldwide.CASE SUMMARY We present the first case of postoperative pulmonary infection in a patient with intracerebral hemorrhage due to Elizabethkingia miricola.The imaging character-istics of pulmonary infection were identified and the formulation and selection of the clinical treatment plan for this patient are discussed.CONCLUSION Elizabethkingia miricola infection is rare.When pulmonary infection occurs,computed tomography imaging may show diffuse distribution of a ground glass density shadow in both lungs,the air containing bronchial sign in local areas,thickening of bronchial vascular bundle,and pleural effusion. | Ping-Qiang Qi Yi-Jun Zeng Wei Peng Juan Kuai | 2024 | World Journal of Clinical Cases2024，12，1： | 0 |
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