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| 1 | RANKL/RANK control Brca1 mutation-driven mammary tumors显示文摘 | Verena Sig Kwadwo Owusu-Boaitey Puma A Joshi Anoop Kavirayani Gerald Wimsberger Maria Novatchkova Ivona Kozieradzki Daniel Schramek Nnamdi Edokobi Jerome Hersl Aishia Sampson Ashley Odai-Afotey Conxi Lazaro Eva Gonzalez-Suarez Miguel A Pujaaa for CIMBA Holger Heyn Enrique Vidal Jennifer Cru. ickshank Hal Berman Renu Sarao Melita Tieevic Iris Uribesalgo Luigi Tortola Shuan Rao Yen Tan Georg Pfeiler Eva YHP Lee Zsuzsanna Bago-Horvath Lukas Kenner Helmuth Popper Christian Singer Rama Khokha LaundeRe P Jones Josef M Penninger | 2016 | Cell Research2016，26，7： | 3 |
| 2 | A vital sugar code for ricin toxicity显示文摘 | Jasmin Taubenschmld Johannes Stadlmann Markus Jost Tove Irene Klok.k Cory D Rillahan Andreas Leibbrandt Karl Mechtler James C Paulson Julian Jude Johannes Zuber Kirsten Sandvig Ulrich Elling Thorsten Marquardt Christian Thiel Christian Koerner Josef M Penninger | 2017 | Cell Research2017，27，11： | 2 |
| 3 | AIF-regulated oxidative phosphorylation supports lung cancer development显示文摘Cancer is a major and still increasing cause of death in humans. Most cancer cells have a fundamentally different metabolic profile from that of normal tissue. This shift away from mitochondrial ATP synthesis via oxidative phosphorylation towards a high rate of glycolysis, termed Warburg effect, has long been recognized as a paradigmatic hallmark of cancer, supporting the increased biosynthetic demands of tumor cells. Here we show that deletion of apoptosis-inducing factor (AIF) in a Kras^G12D-driven mouse lung cancer model resulted in a marked survival advantage, with delayed tumor onset and decreased malignant progression. Mechanistically, Aif deletion leads to oxidative phosphorylation (OXPHOS) deficiency and a switch in cellular metabolism towards glycolysis in non-transformed pneumocytes and at early stages of tumor development. Paradoxically, although Aif-deficient cells exhibited a metabolic Warburg profile, this bioenergetic change resulted in a growth disadvantage of Kras^G12D-driven as well as Kras wild-type lung cancer cells. Cell-autonomous re-expression of both wild-type and mutant AIF (displaying an intact mitochondrial, but abrogated apoptotic function) in Aif-knockout Kras^G12D mice restored OXPHOS and reduced animal survival to the same level as AIF wild-type mice. In patients with non-small cell lung cancer, high AIF expression was associated with poor prognosis. These data show that AIF-regulated mitochondrial respiration and OXPHOS drive the progression of lung cancer. | Shuan Rao Laura Mondragon Blanka Pranjic Toshikatsu Hanada Gautier Stoll Thomas Kocher Peng Zhang Alexander Jais Alexander Lercher Andreas Bergthaler Daniel Schramek Katharina Haigh Valentina Sica Marion Leduc Nazanine Modjtahedi Tsung-Pin Pai Masahiro Onji Iris Uribesalgo Reiko Hanada Ivona Kozieradzki Rubina Koglgruber Shane J. Cronin Zhigang She Franz Quehenberger Helmut Popper Lukas Kenner Jody J. Haigh Oliver Kepp Malgorzata Rak Kaican Cai Guido Kroemer Josef M. Penninger | 2019 | Cell Research2019，29，7： | 2 |
| 4 | Angiotensin-Converting Enzyme 2 Suppresses Pathological Hypertrophy, Myocardial Fibrosis, and Cardiac Dysfunction显示文摘 | JiuChang Zhong Ratnadeep Basu Danny Guo Fung L. Chow Simon Byrns Manfred Schuster Hans Loibner Xiu-hua Wang Josef M. Penninger Zamaneh Kassiri Gavin Y. Oudit | 2010 | Circulation2010，，7： | 2 |
| 5 | Mitogen-activated protein kinases in apoptosis regulation显示文摘 | Wada T Penninger JM | 2004 | Oncogene2004，23，16： | 1 |
| 6 | Regulation of peripheral T cell tolerance by the E3 ubiquitin ligase Cb1-b 显示文摘 | Loeser S Penninger JM | 2007 | Semin hnmunol2007，19，3： | 1 |
| 7 | Lymphopropliferative disorders with early lethality in mice deficient in CTLA-4 显示文摘 | Waterhouse P Penninger JM Timms E | 1995 | Science1995，270，5238： | 1 |
| 8 | Role of Rankl and Rankin bone loss and arthritis显示文摘 | Jones DH Kong YY Penninger JM | | 0，，2： | 1 |
| 9 | TNF Conference 2009:Beyond bones-RANKiyEANK in the immune system显示文摘 | Leibbrandt A Penninger JM | 2011 | Adv Exp Med Biol2011，691，： | 1 |
| 10 | CD45: New jobs for an old acquaintance 显示文摘 | Penninger JM Irie Sasaki J Sasaki T | 2001 | Nat Immunol2001，2，5： | 1 |
| 11 | Implicit uncertainty propagation for robust collaborative optimization显示文摘 | GU X Y RENAUD J E PENNINGER C L | 2006 | Journal of Mechanical Design2006，128，4： | 1 |
| 12 | Lymphoproliferative disorders with early lethality in micedeficient in Ctla--4显示文摘 | Waterhouse P Penninger JM Timms E Wakeham A Shahinian A Lee KP Thompson CB Griesser H Mak TW | 1995 | Science1995，270，： | 1 |
| 13 | Lymphoproliferative Disorders with Early Lethality in Mice Deficient in CTLA-4显示文摘 | WATERHOUSE P PENNINGER JM TIMMS E | 1995 | Science(S1095-9203)1995，270，5238： | 1 |
| 14 | Role of RANKL and RANKin bone loss and arthritis显示文摘 | Jones DH Kong YY Penninger JM | 2002 | Ann Rheum Dis2002，612，： | 1 |
| 15 | RANKL and RANK as novel therapeutic targets for arthritis显示文摘 | Nakashima T WadaT Penninger JM | | 0，，： | 1 |
| 16 | Cbl-b in T-cell activation 显示文摘 | Paolino M Penninger JM | 2010 | SeminImmunopathol2010，32，2： | 1 |
| 17 | Evidence for osteocyte regulation of bone homeostasis through RANKL expression显示文摘 | Nakashima T Hayashi M Fukunaga T Kurata K Oh-Hora M Feng J Q B onewald L F K odama T W utz A W agner E F Penninger JM Takayanagi H | | 0，，： | 1 |
| 18 | Susceptibility to myoear- ditis is dependent on the response of alphabeta T lymphocytes to cox- sackieviral infection 显示文摘 | Opavsky MA Penninger J Aitken K | 1999 | Circ Res1999，85，6： | 1 |
| 19 | Rank-l and rank:T cells,bone loss,and mammalian evolution显示文摘 | Theill LE Boyle WJ Penninger JM | | 0，，0： | 1 |
| 20 | Long-term impact of infantile short bowel syndrome on nutritional status and growth显示文摘 | Olieman JF Penning C Spoel M | | 0，，01： | 1 |
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