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| 1 | 亚太地区胃食管反流病的处理共识:更新版显示文摘背景与目的:自从2004年亚太地区胃食管反流病(GERD)共识发表以来,更多关于GERD流行病学和处理的文献资料相继出现。有必要对这些资料进行循证综述,对共识作出更新。方法:由多学科专家组应用德尔菲(Delphi)法制定共识条文,提呈相关资料,并对证据质量、推荐力度和共识水平进行分级。结果:亚洲GERD发生率日益增加。其危险因素包括老年、男性、种族、家族史、社会经济地位高、体重指数增加和吸烟。对于有典型症状而无报警症状的患者,对质子泵抑制剂(PPI)试验有症状应答具有诊断意义。如PPI试验失败,停止治疗后pH监测结果阴性可排除GERD。窄带成像、胶囊内镜检查和无线pH监测的作用尚未明确。亚洲诊断策略的制定须考虑到并存的胃癌和消化性溃疡。减轻体质量和抬高床头可改善反流症状。PPIs是最有效的内科治疗手段。对于非糜烂性反流病(NERD)患者,按需治疗较为适宜。有慢性咳嗽、喉炎和典型GERD症状的患者在排除非GERD病因后,应予PPI每天两次治疗。如有经验丰富的外科医师,GERD患者可行胃底折叠术。除临床试验外,GERD不应采用内镜治疗。结论:新的诊断方法和内镜治疗的作用有待进一步研究阐明。亚洲GERD诊断策略的制定须考虑到并存的胃癌和消化性溃疡。PPIs仍为治疗的基石。 | Kwong Ming Fock Nicholas J Talley Ronnie Fass Khean Lee Goh Peter Katelaris Richard Hunt Michio Hongo Tiing Leong Ang Gerald Holtmann Sanjay Nandurkar San Ren Lin Benjamin CY Wong Francis KL Chan Abdul Aziz Rani Young-Tae Bak Jose Sollano Khek Yu Ho Sathoporn Manatsathit 钱本余 | 2008 | 胃肠病学2008，13，7： | 21 |
| 2 | Peptic ulcer disease显示文摘 | Peter Malfertheiner Francis KL Chan Kenneth EL McColl | 2009 | The Lancet2009，，9699： | 4 |
| 3 | Peptic ulcer disease显示文摘 | Peter Malfertheiner Francis KL Chan Kenneth EL McColl | 2009 | The Lancet . 2009 (9699)2009，，9699： | 2 |
| 4 | Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling 显示文摘 | Sarkar SN Peters KL Elco CP | 2004 | Nat Struet Mol Biol2004，11，11： | 1 |
| 5 | Quantitative difl\lsion weighted imaging for differentiation of benign and malignant breast lesions: the influence of the choice of b-values 显示文摘 | Peters NH Vincken KL van den Bosch MA | 2010 | J Magn Reson Imaging2010，31，： | 1 |
| 6 | Osteopontin expression in ductal adenocarcinomas and undifferentiated carcinomas of the pancreas显示文摘 | Sedivy R Peters K Kl?ppel G | | 0，，1： | 1 |
| 7 | Ontogeny,differentiation and growth of the endocrine pancreas显示文摘 | Peters J Jürgensen A Klppel G | 2000 | Virchows Arch2000，436，6： | 1 |
| 8 | Fine root growth and demographic responses to nutrient patches in four old-field plant species显示文摘 | Gross KL Peters A Pregitzer KS | | 0，，： | 1 |
| 9 | 显示文摘 | Kenneth MM Peter FF Judith KL | 1994 | JAMA1994，271，： | 1 |
| 10 | Internal reforming of meth-ane in solid oxide fuel cell systems显示文摘 | Peters R Dahl R Klüttgen U | | 0，，： | 1 |
| 11 | Nasal intermittent positive- pressure ventilation offers no advantages over nasal continuous positive airway pressure in apnea of prematurity 显示文摘 | Ryan CA Finer NN Peters KL | 1989 | Am J Dis Child1989，143，10： | 1 |
| 12 | Quantitative diffusion weighted imaging for differentiation of benign and malig nant breast lesions: the influence of the choice of b values显示文摘 | Peters NH Vincken KL van den Bosch MA | 2010 | J Magn Reson Imaging2010，31，5： | 1 |
| 13 | MicroRNA-196a and -196b as Potential Biomarkers for the Early Detection of Familial Pancreatic Cancer显示文摘 | Emily P. Slater Konstantin Strauch Susanne Rospleszcz Annette Ramaswamy Irene Esposito Günter Kl?ppel Elvira Matth?i Kristin Heeger Volker Fendrich Peter Langer Detlef K. Bartsch | 2014 | Translational Oncology2014，，： | 1 |
| 14 | Peptic ulcer disease显示文摘 | Peter Malfertheiner Francis KL Chan Kenneth EL McColl | 2009 | The Lancet2009，，9699： | 1 |
| 15 | Placental volume, as measured by 3-dimensional sonography and levels of maternal plasma cell-free fetal DNA 显示文摘 | Wataganara T Metzenbauer M Peter I Johnson KL Bianchi DW | 2005 | Am J Obstet Gynecol2005，193，2： | 1 |
| 16 | Expression of stem cell markers and transcription factors during the remodeling of the rat pancreas after duct ligation显示文摘 | Katharina Peters Roswitha Panienka Jinming Li Günter Kl?ppel Rennian Wang | 2005 | Virchows Archiv2005，，1： | 1 |
| 17 | Dephosphorylation and Intracellular Redistribution of Ventricular Connexin43 During Electrical Uncoupling Induced by Ischemia显示文摘 | Michael A Beardslee Deborah L Lerner Peter N Tadros James G Laing Eric C Beyer Kathryn A Yamada André G Kléber Richard B Schuessler Jeffrey E Saffitz | 2000 | Circulation Research: Journal of the American Heart Association2000，，： | 1 |
| 18 | Study of the impact of oseltamivir on the risk for pneumonia and other outcomes of influenza,2000 -2005显示文摘 | Peters PH Moscona A Schulman KL ctal | 2008 | Medscape J Med2008，10，6： | 1 |
| 19 | Association of Low Striatal Dopamine D^sub 2^ Receptor Availability With Nicotine Dependence Similar to That Seen With Other Drugs of Abuse显示文摘 | Fehr Christoph Yakushev Igor Hohmann Nina Buchholz Hans-Georg Landvogt Christian Deckers Hanna Eberhardt Alexandra Kl?ger Marie Smolka Michael N Scheurich Armin Dielentheis Thomas Schmidt Lutz G R?sch Frank Bartenstein Peter Gründer Gerhard | 2008 | The American Journal of Psychiatry2008，，4： | 1 |
| 20 | IRF-3-dependent, NFkappa B- and JNK-independent activation of the 561 and IFN-beta genes in response to double-stranded RNA 显示文摘 | Peters KL Smith HL Stark GR | 2002 | Proc Natl Acad Sci USA2002，99，9： | 1 |
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