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| 1 | Low-dose tacrolimus ameliorates liver inflammation and fibrosis in steroid refractory autoimmune hepatitis显示文摘AIM: To determine the eff icacy of tacrolimus on clinical status, histopathological status and biochemical markers in patients with steroid refractory autoimmune hepatitis (AIH). METHODS: Retrospectively, clinical parameters, biochemistry and histology were obtained from patient records. RESULTS: Nine patients [8 females/1 male, median age 32 (range 16-64) years] were identified to have received tacrolimus for a median duration of 18 (12-37) mo. Before initiation of tacrolimus treatment the patients were maintained on a prednisolone dose of 20 mg daily (range 20-80 mg/d), which was tapered to 7.5 (5-12.5) mg/d (P = 0.004). Alanine aminotransferase and immunoglobulin-G concentrations decreased from 154 (100-475) to 47(22-61) U/L (P = 0.007), and from 16 (10-30.2) to 14.5 (8.4-20) g/L (P = 0.032), respectively. All patients showed improvement of the liver inflammatory activity, as determined by the Ishak score (P = 0.016), while the degree of f ibrosis tended to decrease (P = 0.049). CONCLUSION: The use of low dose tacrolimus can lead to biochemical and histologic improvement of inflammation with no progression of the stage of f ibrosis in patients with steroid refractory AIH. Low dose tacrolimus therapy also allows substantial reduction of prednisone dose. | Fin Stolze Larsen Ben Vainer Martin Eefsen Peter Nissen Bjerring Bent Adel Hansen | 2007 | World Journal of Gastroenterology2007，13，23： | 15 |
| 2 | Role of contrast enhanced ultrasonography in the assessment of hepatic metastases:A review显示文摘Contrast enhanced ultrasonography(CEUS) has improved both the detection and characterization of foca liver lesions.It is now possible to evaluate in real time the perfusion of focal liver lesions in the arterial,porta and late contrast phases,and thus to characterize focal liver lesions with high diagnostic accuracy.As a result,CEUS has taken a central diagnostic role in the evaluation of focal liver lesions that are indeterminate upon computed tomography(CT) and magnetic resonance imaging.The combined use of second generation contrast agents and low mechanica index techniques is essential for the detection of liver metastases,and it now allows the examination of the entire liver in both the portal and late phases. Several studies have shown that using CEUS instead of conventional ultrasonography without contrast agents significantly improves sensitivity in detection of liver metastases.Furthermore,the detection rate with CEUS seems to be similar to that of CT.This review describes the clinical role of CEUS in detecting liver metastases,including details about examination techniques,features of metastases observed with CEUS,and clinical results and guidelines. | Lars Peter Skovgaard Larsen | 2010 | World Journal of Hepatology2010，2，1： | 10 |
| 3 | How should liver hypertrophy be stimulated?A comparison of upfront associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)and portal vein embolization(PVE)with rescue possibility显示文摘Background:The role of associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)in comparison to portal vein embolization(PVE)is debated.The aim of this study was to compare successful resection rates(RR)with upfront ALPPS vs.PVE with rescue ALPPS on demand and to compare the hypertrophy of the liver between ALPPS and PVE plus subsequent rescue ALPPS.Methods:A retrospective analysis of all patients treated with PVE for colorectal liver metastasis(CRLM)or ALPPS(any diagnosis,rescue ALPPS included)at five Scandinavian university hospitals during the years 2013-2016 was conducted.A Chi-square test and a Mann-Whitney U test were used to assess the difference between the groups.A successful RR was defined as liver resection without a 90-day mortality.Results:A total of 189 patients were included.Successful RR was in 84.5%of the patients with ALPPS upfront and in 73.3%of the patients with PVE and rescue ALPPS on demand(P=0.080).The hypertrophy of the future liver remnants(FLRs)with ALPPS upfront was 71%(48-97%)compared to 96%(82-113%)after PVE and rescue ALPPS(P=0.010).Conclusions:Upfront ALPPS offers a somewhat higher successful RR than PVE with rescue ALPPS on demand.The sequential combination of PVE and ALPPS leads to a higher overall degree of hypertrophy than upfront ALPPS. | Ernesto Sparrelid Kristina Hasselgren Bård Ingvald Røsok Peter Nørgaard Larsen Nicolai Aagaard Schultz Ulrik Carling Eva Fallentin Stefan Gilg Per Sandström Gert Lindell Bergthor Björnsson | 2021 | Hepatobiliary Surgery and Nutrition2021，10，1： | 2 |
| 4 | Hydraulic roughness of ice covers显示文摘 | LARSEN PETER A | 1997 | Journal of Hydraulic Division ASCE1997，99，1： | 1 |
| 5 | Brain expression of the water channels Aquaporin-1 and -4 in mice with acute liver injury, hyperammonemia and brain edema显示文摘 | Martin Eefsen Peter Jelnes Lars E. Schmidt Ben Vainer Hanne Cathrine Bisgaard Fin S. Larsen | 2010 | Metabolic Brain Disease2010，，3： | 1 |
| 6 | Extracellular matrix dynamics in development and regenerative medicine 显示文摘 | Daley WP Peters SB Larsen M | 2008 | J Cell Sci2008，121，3： | 1 |
| 7 | Scientists perspectives concerning the effects of university patenting on the conduct of academic research in the life sciences显示文摘 | LEE Davis MARIA Larsen PETER Lotz | 2011 | Journal of technology transfers2011，36，1： | 1 |
| 8 | The value of contrast enhanced ultrasonography in detection of liver metastases from colorectal cancer: A prospective double-blinded study显示文摘 | Lars Peter Skovgaard Larsen Mona Rosenkilde Henrik Christensen Niels Bang Lars Bolvig Thomas Christiansen S?ren Laurberg | 2006 | European Journal of Radiology2006，，2： | 1 |
| 9 | Hydraulic roughness of ice covers 显示文摘 | Larsen Peter A | 1973 | Journal of the Hydraulics Division ASCE1973，99，1： | 1 |
| 10 | Co- firing coal and straw in a 150MWe power boiler显示文摘 | Kate Wieck-Hansen Peter Overgaard Ole Hede Larsen | 2000 | Biomass and Bioenergy2000，19，6： | 1 |
| 11 | Characterization of hERG1a and hERG1b potassium channels—a possible role for hERG1b in the I Kr current显示文摘 | Anders Peter Larsen S?ren-Peter Olesen Morten Grunnet Thomas Jespersen | 2008 | Pflügers Archiv - European Journal of Physiology2008，，6： | 1 |
| 12 | Modelling solid-convective flash pyrolysis of straw and wood in the pyrolysis centrifuge reactor 显示文摘 | Niels Bech Morten Boberg Larsen Peter Arendt Jensen | 2009 | Biomass and Bioenergy2009，33，： | 1 |
| 13 | Thyroid Nodule Size and Prediction of Cancer显示文摘 | Sophia C. Kamran Ellen Marqusee Mathew I. Kim Mary C. Frates Julie Ritner Hope Peters Carol B. Benson Peter M. Doubilet Edmund S. Cibas Justine Barletta Nancy Cho Atul Gawande Daniel Ruan Francis D. Moore Karla Pou P. Reed Larsen Erik K. Alexander | 2013 | The Journal of Clinical Endocrinology & Metabolism2013，，2： | 1 |
| 14 | A Positive Diagnostic Strategy Is Noninferior to a Strategy of Exclusion for Patients With Irritable Bowel Syndrome显示文摘 | Luise M. Begtrup Anne Line Engsbro Jens Kjeldsen Pia V. Larsen Ove Schaffalitzky de Muckadell Peter Bytzer Dorte E. Jarb?l | 2013 | Clinical Gastroenterology and Hepatology2013，，8： | 1 |
| 15 | The effect of cooking temperature on mechanical properties of whole meat, single muscle fibres and perimysial connective tissue显示文摘 | Mette Christensen Peter P. Purslow Lone M. Larsen | 2000 | Meat Science2000，，3： | 1 |
| 16 | Idiopathic extensive peliosis hepatis treated with liver transplantation显示文摘 | Masanobu Hyodo Anne Mellon Mogensen Peter N?rgaard Larsen Andre Wettergren Allan Rasmussen Preben Kirkegaard Yoshikazu Yasuda Hideo Nagai | 2004 | Journal of Hepato - Biliary - Pancreatic Surgery2004，，5： | 1 |
| 17 | U.S. ECONOMIC SENSITIVITY TO WEATHER VARIABILITY显示文摘 | Lazo Jeffrey K Lawson Megan Larsen Peter H Waldman Donald M | 2011 | Bulletin of the American Meteorological Society2011，，6： | 1 |
| 18 | Extracellular matrix dynamics in development and regenerative medicine 显示文摘 | WP Daley SB Peters M Larsen J | 2008 | Cell Sci2008，121，3： | 1 |
| 19 | Blood-brain barrier permeability to ammonia in liver failure:a critical reappraisal显示文摘 | Peter O Larsen FS | 2004 | Neurochemistry International2004，44，4： | 1 |
| 20 | A systematic vascular malformastions of ten mandible显示文摘 | Peter E larsen and La Hi J | 1993 | J Oral Maxillofac surg1993，51，： | 1 |
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