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| 1 | Cyclosporine versus tacrolimus in patients with HCV infection after liver transplantation:Effects on virus replication and recurrent hepatitis显示文摘瞄准:决定 calcineurin 禁止者, cyclosporine 和 tacrolimus 的效果,在丙肝上,在病人的周期性的丙肝的病毒(HCV ) 复制和活动张贴肝移植。方法:在我们的中心为在 1999 和 2003 之间的联系 HCV 的肝肝硬化收到了肝移植的 107 个病人的一个队的数据回顾地被分析。浆液 HCV-RNA 的水平和周期性的肝炎的活动在作为主要抑制免疫力的代理人和没在移植以后在开始的 12 瞬间以内导致胆汁的复杂并发症的不那样类似的抑制免疫力的政体收到了 cyclosporine 或 tacrolimus 的 47 个病人之间被比较。结果:HCV-RNA 在移植以后在 3 瞬间以内增加了,但是 cyclosporine 组和 tacrolimus 组之间的差别是不足道的(在 12 瞬间的 P=0.49 ) 。另外,由浆液 transaminases 决定了的周期性的肝炎并且门发炎和纤维变性的组织学的分级没在 12 瞬间(P=0.34 ) 以后显示出有效差量。结论:一个主要抑制免疫力的代理人不在肝移植以后在感染 HCV 的病人影响周期性的肝炎的正式就职或严厉的 Cyclosporine 或 tacrolimus。 | Philip Hilgard Alisan Kahraman Nils Lehmann Cornelia Seltmann Susanne Beckebaum R Stefan Ross Hideo A Baba Massimo Malago Christoph E Broelsch Guido Gerken | 2006 | World Journal of Gastroenterology2006，12，5： | 235 |
| 2 | Phytochemical analysis,hepatoprotective and antioxidant activity of Alchornea cordifolia methanol leaf extract on carbon tetrachloride-induced hepatic damage in rats显示文摘Objective:To investigate the hepatoprotective and antioxidant activities of Alchornea cordifolia (A.cordifolia) leaf extract.Methods:Various solvent fractions of the methanol extract of the leaf of the plant.4.cordifolia Mull.Arg(Fam:Euphorbiaceae) were evaluated for hepatoprotective activity by carbon tetrachloride-induced liver damage in rats.The degree of protection was measured by using biochemical parameters such as serum glutamate oxalate transaminase(SGOT/ AST),serum glutamate pyruvate transaminase(SCPT/ALT),alkaline phosphatase(ALP) and total bilirubin.The in vitro antioxidant activity of the extract was also evaluated by the I,I-diphenyl 2-picrylhydrazyl(DPPH) free radical scavenging assay.The extract was subjected to preliminary phytoehemical screening.Results:The ethyl acetate and chloroform fractions,at a dose of 300 mg/kg,produced significant(P<0.05) hepatoprolection by decreasing the activities of the serum enzymes and bilirubin while there were marked scavenging of the DPPH free radicals by the fractions.The effects were comparable to those of the standard drugs used for the respective experiments,silymarin and ascorbic acid.Alkaloids,flavonoids,saponins and tannins were delected in the phylochemical screening.Conclusion:From this study,it was concluded that the plant of A.cordifolia possesses hepatoprotective as well as antioxidant activities and these activities reside mainly in the ethyl acetate and acetone fractions of methanol leaf extract. | Patience O Osadebe Festus BC Okoye Philip F Uzor Nneka R Nnamani Ijeoma E Adiele Nkemakonam C Obiano | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，4： | 2 |
| 3 | Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trial显示文摘 | S Vincent Rajkumar Susanna Jacobus Natalie S Callander Rafael Fonseca David H Vesole Michael E Williams Rafat Abonour David S Siegel Michael Katz Philip R Greipp | 2010 | Lancet Oncology2010，，1： | 2 |
| 4 | Competing risks survival analysis applied to data from the Australian Orthopaedic Association National Joint Replacement Registry显示文摘 | Marianne H G Philip R Stephen E G | 2010 | Acta Orthopaedica2010，8，5： | 1 |
| 5 | Gene modification of primary tumor cells for active immunotherapy of human breast and ovarian cancer 显示文摘 | Clary B Brunette E | 1996 | Clin Cancer Res1996，2，1： | 1 |
| 6 | Maximum andminimum temperature trends for the globe显示文摘 | David R E Briony H Philip D J | 1997 | Science1997，277，5324： | 1 |
| 7 | q-Profile Measurement in Tokomaks Using Fueling Pellets显示文摘 | Durst R D Philips P E Rowan W L | | 0，，： | 1 |
| 8 | Sap-flux-scaled transpiration responses to light, vapor pressure deficit, and leaf area reduction in a flooded Taxodium distichum forest显示文摘 | Oren R Philips N Ewers B E | 1999 | Tree Physiology1999，19，6： | 1 |
| 9 | Activated Kras, but not Hras or Nras, may initiate tumors of endodermal origin via stem cell expansion显示文摘 | Nlan M P Quatela S E Philips M R | 2008 | Mol Cell Biol2008，28，8： | 1 |
| 10 | Separation of functionalities in pyrolytic tar by gel permeation chromatography-gas chromatography显示文摘 | SHEU Y-H E PHILIP C V ANTHONY R G | 1984 | J Chromatogr Sci1984，22，1： | 1 |
| 11 | EVALUATING HIGH-RESOLUTION PRECIPITATION PRODUCTS显示文摘 | Turk F Joseph Arkin Philip Ebert Elizabeth E Sapiano Mathew R P | 2008 | Bulletin of the American Meteorological Society2008，，12： | 1 |
| 12 | Viral load of human papillomavirus and risk of CIN3 or cervical cancer显示文摘 | Attila T Lorincz Philip E Castle Mark E Sherman David R Scott Andrew G Glass Sholom Wacholder Brenda B Rush Patti E Gravitt John E Schussler Mark Schiffman | 2002 | The Lancet . 2002 (9328)2002，，9328： | 1 |
| 13 | Evolution of CAM and C^sub 4^carbon-concentrating mechanisms显示文摘 | Jon E K Philip W R | 2003 | International Jounal of Plant Science2003，164，3： | 1 |
| 14 | Prevention of aflatoxieosis by addition of hydrated sodium calcium aluminositicate to the diets of growing barrows显示文摘 | Harvey R B Kubena L F Philips T D Huff W E Corrier D E | 1989 | Am J Vet Res1989，50，： | 1 |
| 15 | The D ?0 D ? 0 threshold resonance显示文摘 | Frank E Close Philip R Page | 2003 | Physics Letters B2003，，1： | 1 |
| 16 | Ray tracing analysis of the transmission performance of curved FSS显示文摘 | Parker E A Langley R J | 1995 | Microwaves Antennas and Propagation IEE Proceedings1995，142，3： | 1 |
| 17 | Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite显示文摘 | Abdul R Maher Sayqa Arif Melanie Madhani Khalid Abozguia Ibrar Ahmed Bernadette O Fernandez Martin Feelisch AG O’Sullivan Arthur Christopoulos Aaron L Sverdlov Doan Ngo Rustem Dautov Philip E James John D Horowitz Michael P Frenneaux | 2013 | Br J Pharmacol2013，，3： | 1 |
| 18 | Effect of peanut tannin extracts on growth of Aspergillus parasticus and aflatoxin production 显示文摘 | Pettit R E Sarr B A Philips T D | 1990 | Mycopathologia1990，110，3： | 1 |
| 19 | Biochemistry and cell biology of mammalian scavenger receptors 显示文摘 | Jane E M Philip R T Shervanthi H V | 2005 | Atherosclerosis2005，182，1： | 1 |
| 20 | Active FSS in an experimental horn antenna switchable between two beam widths显示文摘 | PHILIPS B PARKER E A LANGLEY R J | 1955 | Electronics Letters1955，31，1： | 1 |
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