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| 1 | Occurrence of bisphenol A in surface and drinking waters and its physicochemical removal technologies显示文摘Bisphenol A (BPA ) ,内分泌的破坏混合物,在环境和有害效果由于它的宽出现引起了宽公共担心。BPA 与最大的集中在许多表面水和喝的水里被检测了直到十 | Liping LIANG Jing ZHANG Pian FENG Cong LI Yuying HUANG Bingzhi DONG Lina LI Xiaohong GUAN | 2015 | Frontiers of Environmental Science & Engineering2015，9，1： | 5 |
| 2 | Weak magnetic field accelerates chromate removal by zero-valent iron显示文摘Weak magnetic field(WMF) was employed to improve the removal of Cr(VI) by zero-valent iron(ZVI) for the first time. The removal rate of Cr(VI) was elevated by a factor of 1.12–5.89 due to the application of a WMF, and the WMF-induced improvement was more remarkable at higher Cr(VI) concentration and higher p H. Fe2+was not detected until Cr(VI) was exhausted, and there was a positive correlation between the WMF-induced promotion factor of Cr(VI) removal rate and that of Fe2+release rate in the absence of Cr(VI) at pH 4.0–5.5. These phenomena imply that ZVI corrosion with Fe2+release was the limiting step in the process of Cr(VI) removal. The superimposed WMF had negligible influence on the apparent activation energy of Cr(VI) removal by ZVI, indicating that WMF accelerated Cr(VI)removal by ZVI but did not change the mechanism. The passive layer formed with WMF was much more porous than without WMF, thereby facilitating mass transport. Therefore,WMF could accelerate ZVI corrosion and alleviate the detrimental effects of the passive layer, resulting in more rapid removal of Cr(VI) by ZVI. Exploiting the magnetic memory of ZVI, a two-stage process consisting of a small reactor with WMF for ZVI magnetization and a large reactor for removing contaminants by magnetized ZVI can be employed as a new method of ZVI-mediated remediation. | Pian Feng Xiaohong Guan Yuankui Sun Wonyong Choi Hejie Qin Jianmin Wang Junlian Qiao Lina Li | 2015 | Journal of Environmental Sciences2015，27，5： | 2 |
| 3 | Conformal piezoelectric energy harvesting and storage from motions of the heart, lung,and diaphragm显示文摘 | Dagdeviren C Yang B D Su Y Tran P L Joe P An- derson E Xia J Doraiswamy V Dehdashti B Feng X Lu B Poston R Khalpey Z Ghaffari R Huang Y Sle- pian M Rogers J A | 2014 | Proceedings of the National Academy of Sciences2014，111，5： | 1 |
| 4 | Current development of bicyclic peptides显示文摘Bicyclic peptides,a class of polypeptides with two loops within their structure,have emerged as powerful tools in the development of new peptide drugs.They have the potential to bind to challenged drug targets,with antibody-like affinity and selectivity.Meanwhile,bicyclic peptides possess small molecule-like access to chemical synthesis,which is conducive to large-scale synthesis and screening.In the last five years,bicyclic peptide technology has been increasingly developed,and researchers have carried out a variety of studies to elucidate the potential functions of bicyclic peptides.With the continuous development of synthetic methods and the advances of new technology to build bicyclic peptide libraries,bicyclic peptides are now becoming widely used in the development of new drugs for various diseases.This perspective provides an overview of the structure types,synthesis and applications of bicyclic peptides in current drug development,and our own views on future challenges of bicyclic peptides. | Dazhi Feng Lihua Liu Yuqi Shi Pian Du Shengtao Xu Zheying Zhu Jinyi Xu Hong Yao | 2023 | Chinese Chemical Letters2023，34，6： | 0 |
| 5 | Identification of HMGCR as the anticancer target of physapubenolide against melanoma cells by in silico target prediction显示文摘Physapubenolide(PB),a withanolide-type compound extracted from the traditional herb Physalis minima L.,has been demonstrated to exert remarkable cytotoxicity against cancer cells;however,its molecular mechanisms are still unclear.In this study,we demonstrated that PB inhibited cell proliferation and migration in melanoma cells by inducing cell apoptosis.The anticancer activity of PB was further verified in a melanoma xenograft model.To explore the mechanism underlying the anticancer effects of PB,we carried out an in silico target prediction study,which combined three approaches(chemical similarity searching,quantitative structure-activity relationship(QSAR),and molecular docking)to identify the targets of PB,and found that PB likely targets 3-hydroxy-methylglutaryl CoA reductase(HMGCR),the rate-limiting enzyme of the mevalonate pathway,which promotes cancer cell proliferation,migration,and metastasis.We further demonstrated that PB interacted with HMGCR,decreased its protein expression and inhibited the HMGCR/YAP pathway in melanoma cells.In addition,we found that PB could restore vemurafenib sensitivity in vemurafenib-resistant A-375 cells,which was correlated with the downregulation of HMGCR.In conclusion,we demonstrate that PB elicits anticancer action and enhances sensitivity to vemurafenib by targeting HMGCR. | Hai-yan Wang Pian Yu Xi-sha Chen Hui Wei Shi-jie Cao Meng Zhang Yi Zhang Yong-guang Tao Dong-sheng Cao Feng Qiu Yan Cheng | 2022 | Acta Pharmacologica Sinica2022，43，6： | 0 |
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