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| 1 | Management of digestive bleeding related to portal hypertension in cirrhotic patients:A French multicenter cross-sectional practice survey显示文摘AIM: To investigate the conformity of management practices of gastrointestinal hemorrhage in cirrhotic patients with relevant guidelines. METHODS: A questionnaire on the management of digestive bleeding was completed for all consecutive cirrhotic patients admitted to 31 French hospitals. RESULTS: One hundred and twenty-six bleeding events were recorded. It was the first bleeding episode in 79 patients (63%), of whom 40 (51%) had a prior diagnosis of cirrhosis and 25 (32%) had previously undergone an endoscopy. The bleeding episode was a recurrence in 46 patients (37%). The median time between onset and admission was 4 h, but exceeded 12 h in 42% of cases. There was an agreement between centers forearly vasoactive drug administration (87% of cases), association with ligation (42%) more often than sclerosis (21%) at initial endoscopy, and antibiotic prophylaxis (64%). By contrast, prescription of beta-blockade alone or in combination (0 to 100%, P = 0.003) for secondary prophylaxis and lactulose (26% to 86%, P = 0.04), differed among centers. CONCLUSION: In French hospitals, management of bleeding related to portal hypertension in cirrhotic patients is generally in keeping with the consensus. Broad variability still remains concerning beta-blockade use for secondary prophylaxis. Screening for esophageal varices, the use of antibiotic prophylaxis and patients information need to be improved. | Pierre Ingrand Jérme Gournay Pierre Bernard Frédéric Oberti Brigitte Bernard-Chabert Arnault Pauwels Philippe Renard Eric Bartoli Jean-Franois Cadranel Jean-Claude Barbare Isabelle Ingrand Michel Beauchant | 2006 | World Journal of Gastroenterology2006，12，48： | 4 |
| 2 | Ribavirin:Past,present and future显示文摘Before the advent of direct acting antiviral agents(DAAs) ribavirin, associated to pegylated-interferon played a crucial role in the treatment of chronic hepatitis C, preventing relapses and breakthroughs. In the present era of new potent DAAs, a place is still devoted to the drug. Ribavirin associated with sofosbuvir alone is efficient in the treatment of most cases of G2 infected patients. All options currently available for the last difficult-to-treat cirrhotic G3 patients contain ribavirin. Reducing treatment duration to 12 wk in G1 or G4 cirrhotic compensated patients is feasible thanks to ribavirin. Retreating patients with acquired anti NS5 A resistance-associated variants using ribavirin-based strategies could be useful. The addition of ribavirin with DAAs combinations however, leads to more frequent but mild adverse events especially in cirrhotic patients. Preliminary data with interferon-free second generation DAAs combinations without ribavirin suggest that future of the drug is jeopardized even in difficult-totreat patients: The optimization of ribavirin dosage according to an early monitoring of blood levels has been suggested to be relevant in double therapy with peginterferon or sofosbuvir but not with very potent combinations of more than two DAAs. | Véronique Loustaud-Ratti Marilyne Debette-Gratien Jérémie Jacques Sophie Alain Pierre Marquet DenisSautereau Annick Rousseau Paul Carrier | 2016 | World Journal of Hepatology2016，8，2： | 3 |
| 3 | Role of endoscopic ultrasound in the molecular diagnosis of pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma remains one of the most deadly types of tumor. Endoscopic ultrasoundguided fine-needle aspiration(EUS-FNA) is a safe, cost-effective, and accurate technique for evaluating and staging pancreatic tumors. However, EUS-FNA may be inconclusive or doubtful in up to 20% of cases. This review underlines the clinical interest of the molecular analysis of samples obtained by EUS-FNA in assessing diagnosis or prognosis of pancreatic cancer, especially in locally advanced tumors. On EUS-FNA materials DNA, mRNA and miRNA can be extracted, amplified, quantified and subjected to methylation assay. Kras mutation assay, improves diagnosis of pancreatic cancer. When facing to clinical and radiological presentations of pseudo-tumorous chronic pancreatitis, wildtype Kras is evocative of benignity. Conversely, in front of a pancreatic mass suspected of malignancy, a mutated Kras is highly evocative of pancreatic adenocarci-noma. This strategy can reduce false-negative diagnoses, avoids the delay of making decisions and reduces loss of surgical resectability. Similar approaches are conducted using analysis of miRNA expression as well as Mucin or markers of invasion(S100P, S100A6, PLAT or PLAU). Beyond the diagnosis approach, the prediction of response to treatment can be also investigated form biomarkers expression within EUS-FNA materials. | Barbara Bournet Marion Gayral Jérme Torrisani Janick Selves Pierre Cordelier Louis Buscail | 2014 | World Journal of Gastroenterology2014，20，31： | 3 |
| 4 | HCV ‐associated B ‐cell non‐ H odgkin lymphomas and new direct antiviral agents显示文摘 | Paul Carrier Arnaud Jaccard Jérémie Jacques Tessa Tabouret Marilyne Debette‐Gratien Julie Abraham Laura Mesturoux Pierre Marquet Sophie Alain Denis Sautereau Marie Essig Véronique Loustaud‐Ratti | 2015 | Liver Int2015，，10： | 2 |
| 5 | Photonic Crystals: Putting a New Twist on Light显示文摘 | Villeneuve Pierre R Shanhui Fan | 1997 | Nature1997，383，： | 1 |
| 6 | Ce 3d XPS study of composite Cex Mn1-xO2-ywet oxidation catalysts显示文摘 | LARACHI R PIERRE J ADNOT A BERNIS A | 2002 | Appl Surf Sci2002，195，14： | 1 |
| 7 | Sulfur Equilibria Between Gases and Slags Containing FeO 显示文摘 | Pierre G R S Chipman J | 1956 | J Met1956，，10： | 1 |
| 8 | MicroRNA-21 Is Induced Early in Pancreatic Ductal Adenocarcinoma Precursor Lesions显示文摘 | du Rieu Ma?l Chalret Torrisani Jér?me Selves Janick Al Saati Talal Souque Anny Dufresne Marlène Tsongalis Gregory J Suriawinata Arief A Carrére Nicolas Buscail Louis Cordelier Pierre | 2010 | Clinical Chemistry2010，，： | 1 |
| 9 | Photonic crystals:Putting a new twist on light显示文摘 | Joannopoulos J D Pierre R Villeneuve Fan Shanhui | 1997 | Nature1997，386，6621： | 1 |
| 10 | Use of ARMA block processing for estimating stationary low-frequency electromechanical modes of power systems显示文摘 | Wies R W Pierre J W Trudnowski D J | 2003 | IEEE Trans on Power Systems2003，18，1： | 1 |
| 11 | Quadrature receiver mismatch calibration 显示文摘 | Green R A Anderson-Sprecher R Pierre J W | 1999 | IEEE Trans on Signal Processing1999，47，11： | 1 |
| 12 | Use of ARMA block processing for estimating stationary low-frequency electromechanical modes of power systems显示文摘 | WIES R W PIERRE J W TRUNDNOWSKI D J | 2003 | IEEE Trans on Power Systems2003，18，1： | 1 |
| 13 | Use of ARMAblockprocessingforestimatingstationarylow-frequency electromechan-ical modes of power systems显示文摘 | WIES R W PIERRE J W TRUDNOWSKI D J | 2003 | IEEE Trans on Power Systems2003，18，1： | 1 |
| 14 | Arthroscopy of the elbow 显示文摘 | Andrews J R Pierre P K Carson W G | 1986 | Clin Sports Med1986，5，： | 1 |
| 15 | Dissociated pulmonary vein arrhythmia: Incidence and characteristics显示文摘 | Weerasooriya R Pierre J Scavee C | 2003 | JCE2003，14，： | 1 |
| 16 | Experimental investigation on the dynamic behavior of flexible conductors between substation equipment during an earthquake 显示文摘 | Dastous J-B Pierre J R | 1996 | IEEE Transactions on Power Delivery1996，，： | 1 |
| 17 | Surviving hypoxia without really dying显示文摘 | Boutilier R G Pierre S J | 2000 | Comp Bioehem Physiol A Mol Integr Physiol2000，126，4： | 1 |
| 18 | Click and bioorthogonal hyaluronic acid hydrogels as an ultra-tunable platform for the investigation of cell-material interactions显示文摘The cellular microenvironment plays a major role in the biological functions of cells.Thus,biomaterials,especially hydrogels,which can be design to mimic the cellular microenvironment,are being increasingly used for cell encapsulation,delivery,and 3D culture,with the hope of controlling cell functions.Yet,much remains to be understood about the effects of cell-material interactions,and advanced synthetic strategies need to be developed to independently control the mechanical and biochemical properties of hydrogels.To address this challenge,we designed a new hyaluronic acid(HA)-based hydrogel platform using a click and bioorthogonal strain-promoted azide-alkyne cycloaddition(SPAAC)reaction.This approach facilitates the synthesis of hydrogels that are easy to synthesize and sterilize,have minimal swelling,are stable long term,and are cytocompatible.It provides bioorthogonal HA gels over an uncommonly large range of stiffness(0.5-45 kPa),all forming within 1-15 min.More importantly,our approach offers a versatile one-pot procedure to independently tune the hydrogel composition(e.g.,polymer and adhesive peptides).Using this platform,we investigate the independent effects of polymer type,stiffness,and adhesion on the secretory properties of human adipose-derived stromal cells(hASCs)and demonstrate that HA can enhance the secretion of immunomodulatory factors by hASCs. | Nathan Lagneau Pierre Tournier Boris Halgand François Loll Yves Maugars Jérôme Guicheux Catherine Le Visage Vianney Delplace | 2023 | Bioactive Materials2023，，6： | 1 |
| 19 | Old iron, young copper: from Mars to Venus显示文摘 | CRICHT()N R R PIERRE J L | 2001 | BioMetals2001，14，2： | 1 |
| 20 | Homoeysteinein Dueessynthessota Serineel astanarterial smoothmuse cells from utiorgandonors 显示文摘 | Dominique J R Pierre H R Eugenio R | 1997 | Cardiovaseular Research1997，，： | 1 |
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