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| 1 | Leptin signaling and cancer chemoresistance:Perspectives显示文摘Obesity is a major health problem and currently is endemic around the world. Obesity is a risk factor for several different types of cancer, significantly promoting cancer incidence, progression, poor prognosis and resistance to anti-cancer therapies. The study of this resistance is critical as development of chemoresistance is a serious drawback for the successful and effective drug-based treatments of cancer. There is increasing evidence that augmented adiposity can impact on chemotherapeutic treatment of cancer and the development of resistance to these treatments, particularly through one of its signature mediators, the adipokine leptin. Leptin is a pro-inflammatory, pro-angiogenic and pro-tumorigenic adipokine that has been implicated in many cancers promoting processes such as angiogenesis, metastasis, tumorigenesis and survival/resistance to apoptosis. Several possible mechanisms that could potentially be developed by cancer cells to elicit drug resistance have been suggested in the literature. Here, we summarize and discuss the current state of the literature on the role of obesity and leptin on chemoresistance, particularly as it relates to breast and pancreatic cancers. We focus on the role of leptin and its significance in possibly driving these proposed chemoresistance mechanisms, and examine its effects on cancer cell survival signals and expansion of the cancer stem cell sub-populations. | Pierre V Candelaria Antonio Rampoldi Adriana Harbuzariu Ruben R Gonzalez-Perez | 2017 | World Journal of Clinical Oncology2017，8，2： | 6 |
| 2 | Ribavirin:Past,present and future显示文摘Before the advent of direct acting antiviral agents(DAAs) ribavirin, associated to pegylated-interferon played a crucial role in the treatment of chronic hepatitis C, preventing relapses and breakthroughs. In the present era of new potent DAAs, a place is still devoted to the drug. Ribavirin associated with sofosbuvir alone is efficient in the treatment of most cases of G2 infected patients. All options currently available for the last difficult-to-treat cirrhotic G3 patients contain ribavirin. Reducing treatment duration to 12 wk in G1 or G4 cirrhotic compensated patients is feasible thanks to ribavirin. Retreating patients with acquired anti NS5 A resistance-associated variants using ribavirin-based strategies could be useful. The addition of ribavirin with DAAs combinations however, leads to more frequent but mild adverse events especially in cirrhotic patients. Preliminary data with interferon-free second generation DAAs combinations without ribavirin suggest that future of the drug is jeopardized even in difficult-totreat patients: The optimization of ribavirin dosage according to an early monitoring of blood levels has been suggested to be relevant in double therapy with peginterferon or sofosbuvir but not with very potent combinations of more than two DAAs. | Véronique Loustaud-Ratti Marilyne Debette-Gratien Jérémie Jacques Sophie Alain Pierre Marquet DenisSautereau Annick Rousseau Paul Carrier | 2016 | World Journal of Hepatology2016，8，2： | 3 |
| 3 | HCV ‐associated B ‐cell non‐ H odgkin lymphomas and new direct antiviral agents显示文摘 | Paul Carrier Arnaud Jaccard Jérémie Jacques Tessa Tabouret Marilyne Debette‐Gratien Julie Abraham Laura Mesturoux Pierre Marquet Sophie Alain Denis Sautereau Marie Essig Véronique Loustaud‐Ratti | 2015 | Liver Int2015，，10： | 2 |
| 4 | Differences in gene expression profiles of diabetic and nondiabetic patients undergoing cardiopulmonary bypass and cardioplegic arrest显示文摘 | Pierre V Marc R Tanveer A K | 2004 | Circulation2004，110，2： | 1 |
| 5 | Pseudothrombocytopenia: a labora- tory artifact with potentially serious consequences 显示文摘 | Payne B A Pierre R V | 1984 | Mayo Clin Proc1984，59，2： | 1 |
| 6 | Streamwise-travelling waves of spanwise wall velocity for turbulent drag reduction显示文摘 | Maurizio Q Pierre R Claudio V | 2009 | Journal of Fluid Mechanics2009，627，： | 1 |
| 7 | Seasonally resolved nutrient export fluxes and filtering capacties in a macrtidal estuary 显示文摘 | Sandra A Pierre R Jean Piere V | 2009 | Journal of Marine Systems2009，78，： | 1 |
| 8 | Enhancing the performance of exterior waterborne coatings for wood by inorganic nanosized UV Absorbers 显示文摘 | Mirela V C Bernard R Pierre B | 2010 | Progress in Organic Coatings2010，69，4： | 1 |
| 9 | Linear waveguides in photonic-crystal slabs显示文摘 | STEVEN G J PIERRE R V SHANHUI F | 2000 | Physical Review B2000，62，12： | 1 |
| 10 | A recurrent deletion of DPY19L2 causes infertility in man by blocking sperm head elongation and acrosome forma- tion显示文摘 | Harbuz R Zouari R Pierre V | 2011 | Am J Hum Genet2011，88，3： | 1 |
| 11 | Glucotoxicity inhibits late steps of insulin exocytosis显示文摘 | Mathilde D Pierre V Benoit R | 2007 | Endocrinology2007，148，4： | 1 |
| 12 | Surface complexation effects on phosphate adsorption to ferric iron oxyhydroxides along pH and salinity gradients in estuaries and coastal aquifers 显示文摘 | Claudette S Philippe V C Pierre R | 2008 | Geochimica et Cosmochimica Acta2008，72，14： | 1 |
| 13 | Tracheal relaxation of five Ivorian anti-asthmatic plants: Role of epithelium and K + channels in the effect of the aqueous-alcoholic extract of Dichrostachys cinerea root bark显示文摘 | Geneviève Irié-N'guessan Pierre Champy Gisèle Kouakou-Siransy Armand Koffi Brou Jér?me Kablan Véronique Leblais | 2011 | Journal of Ethnopharmacology2011，，2： | 1 |
| 14 | Subcutaneous Ustekinumab Provides Clinical Benefit for Two-Thirds of Patients With Crohn’s Disease Refractory to Anti–Tumor Necrosis Factor Agents显示文摘 | Pauline Wils Yoram Bouhnik Pierre Michetti Bernard Flourie Hedia Brixi Anne Bourrier Matthieu Allez Bernard Duclos Jean-Charles Grimaud Anthony Buisson Aurélien Amiot Mathurin Fumery Xavier Roblin Laurent Peyrin-Biroulet Jér?me Filippi Guillaume Bouguen V | 2016 | Clinical Gastroenterology and Hepatology2016，，2： | 1 |
| 15 | Removal of PCBs from waste water using fly ash显示文摘 | Hendrik N Murielle R Pierre L Paul V M Will Y V | 2003 | Chemosphere2003，53，6： | 1 |
| 16 | Multiple myeloma and acute myelomonocytic leukemia显示文摘 | KYLE R A PIERRE R V BAYRD E D | | 0，，21： | 1 |
| 17 | β1 integrin/Fak/Src signaling in intestinal epithelial crypt cell survival: integration of complex regulatory mechanisms显示文摘 | Véronique Bouchard Charlène Harnois Marie-Josée Demers Sonya Thibodeau Vincent Laquerre Rémy Gauthier Anne Vézina Dominique No?l Naoya Fujita Takashi Tsuruo Mélina Arguin Pierre H. Vachon | 2008 | Apoptosis2008，，4： | 1 |
| 18 | Identification of new non- coding RNAs in Listeria monocytogenes and prediction of mRNA targets显示文摘 | Pierre M Francis R Massimo V | 2007 | Nucleic Acids Research2007，35，3： | 1 |
| 19 | Multiple myeloma and acute leukemia associated with alkylating agents显示文摘 | KYLE R A PIERRE R V BAYRD E D | | 0，，1： | 1 |
| 20 | Selection for nutrients by red deer hinds feeding on a mixed forest edge显示文摘 | Hélène V T Pierre C R Nicolas M | 2008 | Acta Oecol2008，156，： | 1 |
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