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| 1 | New challenges in perioperative management of pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma(PDAC)is the fourth leading cause of cancer-related death in the industrialized world.Despite progress in the understanding of the molecular and genetic basis of this disease,the5-year survival rate has remained low and usually does not exceed 5%.Only 20%-25%of patients present with potentially resectable disease and surgery represents the only chance for a cure.After decades of gemcitabine hegemony and limited therapeutic options,more active chemotherapies are emerging in advanced PDAC,like 5-Fluorouracil,folinic acid,irinotecan and oxaliplatin and nab-paclitaxel plus gemcitabine,that have profoundly impacted therapeutic possibilities.PDAC is considered a systemic disease because of the high rate of relapse after curative surgery in patients with resectable disease at diagnosis.Neoadjuvant strategies in resectable,borderline resectable,or locally advanced pancreatic cancer may improve outcomes.Incorporation of tissue biomarker testing and imaging techniques into preoperative strategies should allow clinicians to identify patients who may ultimately achieve curative benefit from surgery.This review summarizes current knowledge of adjuvant and neoadjuvant treatment for PDAC and discusses the rationale for moving from adjuvant to preoperative and perioperative therapeutic strategies in the current era of more active chemotherapies and personalized medicine.We also discuss the integration of good specimen collection,tissue biomarkers,and imaging tools into newly designed preoperative and perioperative strategies. | Francesco Puleo Raphaёl Maréchal Pieter Demetter Maria-Antonietta Bali Annabelle Calomme Jean Closset Jean-Baptiste Bachet Jacques Deviere Jean-Luc Van Laethem | 2015 | World Journal of Gastroenterology2015，21，8： | 4 |
| 2 | TTF-1 positive small cell cancers:Don't think they're always primary pulmonary!显示文摘Thyroid transcription factor 1 (TTF-1) plays a key role in morphogenesis of the lungs and is expressed in up to 90% of pulmonary small cell carcinomas.This explains why this marker is frequently used in the search for the primary origin of metastatic endocrine tumours.Here we report on a TTF-1 expressing mixed endocrine-exocrine carcinoma of the common bile duct in a patient with pulmonary nodules that did not appear to be neoplastic.TTF-1 positivity in pulmonary and extrapulmonary neuroendocrine tumours is reviewed,and we conclude that TTF-1 expression in neuroendocrine tumours of the small-cell type are not uncommon at extrapulmonary locations.Therefore,immunohistochem-istry for TTF-1 in such tumours should be interpreted with caution. | Laurine Verset Marianna Arvanitakis Patricia Loi Jean Closset Myriam Delhaye Myriam Remmelink Pieter Demetter | 2011 | World Journal of Gastrointestinal Oncology2011，3，10： | 2 |
| 3 | Common polymorphism in the PNPLA3 /adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease显示文摘 | Eric Trépo Thierry Gustot Delphine Degré Arnaud Lemmers Laurine Verset Pieter Demetter Romy Ouziel Eric Quertinmont Vincent Vercruysse Leila Amininejad Pierre Deltenre Olivier Le Moine Jacques Devière Denis Franchimont Christophe Moreno | 2011 | Journal of Hepatology2011，，4： | 2 |
| 4 | Pancreatic neuroendocrine tumor: Added value of fusion of T2-weighted imaging and high b -value diffusion-weighted imaging for tumor detection显示文摘 | Renata Brenner Thierry Metens Maria Bali Pieter Demetter Celso Matos | 2012 | European Journal of Radiology2012，，5： | 1 |
| 5 | Expression of SGLT1, Bcl-2 and p53 in Primary Pancreatic Cancer Related to Survival显示文摘 | Veerle F. Casneuf Philippe Fonteyne Nancy Van Damme Pieter Demetter Patrick Pauwels Bernard de Hemptinne Martine De Vos Christophe Van de Wiele Marc Peeters | 2008 | Cancer Investigation2008，，8： | 1 |
| 6 | Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice显示文摘 | Takiishi Tatiana Korf Hannelie Van Belle Tom L Robert Sofie Grieco Fabio A Caluwaerts Silvia Galleri Letizia Spagnuolo Isabella Steidler Lothar Van Huynegem Karolien Demetter Pieter Wasserfall Olive Atkinson Mark A Dotta Francesco Rottiers | 2012 | EN2012，，5： | 1 |
| 7 | Neoadjuvant Chemoradiation Versus Hyperfractionated Accelerated Radiotherapy in Locally Advanced Rectal Cancer显示文摘 | Wim Ceelen MD Tom Boterberg MD PhD Piet Pattyn MD PhD Marc Eijkeren MD PhD Jean-Marc Gillardin MD Pieter Demetter MD PhD Peter Smeets MD Nancy Damme PhD Els Monsaert MD Marc Peeters MD PhD | 2007 | Annals of Surgical Oncology2007，，2： | 1 |
| 8 | Transient elastography using Fibroscan is the most reliable noninvasive method for the diagnosis of advanced fibrosis and cirrhosis in alcoholic liver disease显示文摘 | Michael Fernandez Eric Trépo Delphine Degré Thierry Gustot Laurine Verset Pieter Demetter Jacques Devière Michael Adler Christophe Moreno | 2015 | European Journal of Gastroenterology & Hepatology2015，，： | 1 |
| 9 | The interleukin‐17 pathway is involved in human alcoholic liver disease显示文摘 | Arnaud Lemmers Christophe Moreno Thierry Gustot Rapha?l Maréchal Delphine Degré Pieter Demetter Patricia de Nadai Albert Geerts Eric Quertinmont Vincent Vercruysse Olivier Le Moine Jacques Devière | 2009 | Hepatology2009，，2： | 1 |
| 10 | Limited influences of chemotherapy on healthy and metastatic liver parenchyma显示文摘AIM: To examine the expression of E-cadherin, β-catenin,γ-catenin, VEGF, and p53 in 39 patients with hepatic metastasis from colorectal cancer immunohistochemically.METHODS: The patients were divided into two groups:those (n = 16) who had no chemotherapy for at least 6 mo before the liver resections and those (n = 23)who were treated with chemotherapy before liver resections. A score from 0 to 3 was given for the number of positive cells and from 0 to 3 for the intensity of staining in these cells, in both healthy and metastatic liver parenchyma.RESULTS: No significant differences in the expression of E-cadherin, β- and γ-catenin, VEGF and p53, could be observed between patients who received and did not receive chemotherapy, in both normal and metastatic liver parenchyma.CONCLUSION: Despite the assumption that chemotherapy had an effect on liver metastasis, no influences were noticed immunohistochemically. | Nancy Van Damme Pieter Demetter Wouter De Bock Marianne Rottiers Marleen Praet Bernard de Hemptinne Marc Peeters | 2005 | World Journal of Gastroenterology2005，11，34： | 0 |
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