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| 1 | Endosonography-guided cholangiopancreatography as a salvage drainage procedure for obstructed biliary and pancreatic ducts显示文摘Endoscopic ultrasound allows transmural access to the bile or pancreatic ducts and subsequent contrast injection to provide ductal drainage under fluoroscopy using endoscopic retrograde cholangiopancreatography (ERCP)-based techniques.Differing patient specifics and operator techniques result in six possible variant approaches to this procedure,known as endosonography-guided cholangiopancreatography(ESCP). ESCP has been in clinical use for a decade now,with over 300 cases reported.It has become established as a salvage procedure after failed ERCP in the palliation of malignant biliary obstruction.Its role in the management of clinically severe chronic/relapsing pancreatitis remains under scrutiny.This review aims to clarify the concepts underlying the use of ESCP and to provide technical tips and a detailed step-by-step procedural description. | Manuel Perez-Miranda Carlos de la Serna Pilar Diez-Redondo Juan J Vila | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，6： | 15 |
| 2 | Inflammatory status in human hepatic cirrhosis显示文摘This review focuses on new findings about the inflammatory status involved in the development of human liver cirrhosis induced by the two main causes, hepatitis C virus(HCV) infection and chronic alcohol abuse, avoiding results obtained from animal models. When liver is faced to a persistent and/or intense local damage the maintained inflammatory response gives rise to a progressive replacement of normal hepatic tissue by non-functional fibrotic scar. The imbalance between tissue regeneration and fibrosis will determine the outcome toward health recovery or hepatic cirrhosis. In all cases progression toward liver cirrhosis is caused by a dysregulation of mechanisms that govern the balance between activation/homeostasis of the immune system. Detecting differences between the inflammatory status in HCV-induced vs alcoholinduced cirrhosis could be useful to identify specific targets for preventive and therapeutic intervention in each case. Thus, although survival of patients with alcoholic cirrhosis seems to be similar to that of patients with HCV-related cirrhosis(HCV-C), there are important differences in the altered cellular and molecular mechanisms implicated in the progression toward human liver cirrhosis. The predominant features of HCV-C are more related with those that allow viral evasion of the immune defenses, especially although not exclusively, inhibition of interferons secretion, natural killer cells activation and T cell-mediated cytotoxicity. On the contrary, the inflammatory status of alcohol-induced cirrhosis is determined by the combined effect of direct hepatotoxicity of ethanol metabolites and increases of the intestinal permeability, allowing bacteria and bacterial products translocation, into the portal circulation, mesenteric lymph nodes and peritoneal cavity. This phenomenon generates a stronger pro-inflammatory response compared withHCV-related cirrhosis. Hence, therapeutic intervention in HCV-related cirrhosis must be mainly focused to counteract HCV-immune system evasion, while in the case of alcohol-induced cirrhosis it must try to break the inflammatory loop established at the gutmesenteric lymph nodes-peritoneal-systemic axis. | María Martínez-Esparza María Tristán-Manzano Antonio J Ruiz-Alcaraz Pilar García-Penarrubia | 2015 | World Journal of Gastroenterology2015，21，41： | 10 |
| 3 | Stem cell therapy in inflammatory bowel disease: A promising therapeutic strategy?显示文摘Inflammatory bowel diseases are inflammatory, chronic and progressive diseases of the intestinal tract for which no curative treatment is available. Research in other fields with stem cells of different sources and with immunoregulatory cells(regulatory T-lymphocytes and dendritic T-cells) opens up new expectations for their use in these diseases. The goal for stem cell-based therapy is to provide a permanent cure. To achieve this, it will be necessary to obtain a cellular product, original or genetically modified, that has a high migration capacity and homes into the intestine, has high survival after transplantation, regulates the immune reaction while not being visible to the patient's immune system, and repairs the injured tissue. | Ana I Flores Gonzalo J Gómez-Gómez ángeles Masedo-González M Pilar Martínez-Montiel | 2015 | World Journal of Stem Cells2015，7，2： | 7 |
| 4 | Chitosan and Chitosan/ethylene oxide-propylene oxide block copolymer nanoparticles as noval carriers for proteins and vaccines显示文摘 | PILAR C CARMEN R L JOSE LUIS V J | 1997 | Pharm Res1997，14，10： | 1 |
| 5 | Biomass gasification with air in fluidized bed: Reforming of the gas composition with commercial steam reforming catalysts 显示文摘 | Corella J Alberto O Pilar A | 1998 | Ind Eng Chem Res1998，37，12： | 1 |
| 6 | Effect of water activity and temperature on competing abilities of common postharvest citrus fungi 显示文摘 | Pilar P Usall J | 2004 | Int J Food Microbiol2004，90，： | 1 |
| 7 | Minimum and maximum velocities for fluidization for mixtures of agricultural and forest residues with second fluidized solid显示文摘 | Pilar Aznar M Gracia-Gorria F A Corella J | 1992 | International Chemical Engineering1992，32，： | 1 |
| 8 | Organizational Learning Capability: a Pro- posal of Measurement 显示文摘 | PILAR J | 2005 | Journal of Business Re- search2005，58，6： | 1 |
| 9 | Are non-linear C-H…O contacts hydrogen bonds or Van der Waals interactions?:Establishing the limits between hydrogen bonds and Van der Waals interactions显示文摘 | Juan J Novoa Pilar Lafuente Femando Mota | 1998 | Chem Phys Lett1998，290，46： | 1 |
| 10 | Cellular toxicity of inorganic nanopartieles: Common aspects and guidelines for improved nanotoxicity evaluation显示文摘 | Stefaan J S Pilar R G | 2011 | Nano Today2011，6，5： | 1 |
| 11 | Antioxidant and antimicrobial activities of tea in- fusions显示文摘 | M Pilar Almajano Rosa Carbe J Angel Lepez Jimenez | 2008 | Food Chemistry2008，108，1： | 1 |
| 12 | Postharvest changes in broccoli and let-tuce during storage in argon,helium,and nitrogen atmospherescontaining 2%oxygent显示文摘 | Pilar J Saltveit M E | 2002 | Postharvest Biology and Technology2002，，26： | 1 |
| 13 | Antioxidant and antimicrobial activities of tea infusions显示文摘 | Pilar Almajano M Rosa Carbo J Angel Lopez Jimenez | 2008 | Food Chemistry2008，108，1： | 1 |
| 14 | Seasonal carbon storage and growth in Mediterranean tree seedlings under different water conditions显示文摘 | Virginia S Pilar C Richard J | | Tree Physiology0，29，： | 1 |
| 15 | Osmoregulatory action of PRL, GH, and cortisol in the gihhead sea bream 显示文摘 | MANCERA M J CARRION R L MARTIN-DEL- PILAR M D R | 2002 | General and Comparative Endocrinology2002，129，2： | 1 |
| 16 | Organizational learning capability: a proposal of measurement 显示文摘 | Pilar J G Jose C L Ramo V C | 2005 | Journal of Business Research2005，58，6： | 1 |
| 17 | Application of a headspace mass spectrometry system to the differentiation and classification of wines according to their origin variety and ageing显示文摘 | Pilar M Busto O Guasch J | 2004 | Journal of Chromatography A2004，1057，： | 1 |
| 18 | Application of a headspace mass spectrometry system to the differentiation and classification of wines according to their origin,variety and ageing显示文摘 | Pilar Mart'l M Busto O Guasch J | 2004 | Journal of Chromatography A2004，1057，： | 1 |
| 19 | Effect of pH ad the presence of NaCl on some hydration properties of collagenous material from trout muscle and skin显示文摘 | Pilar M Francisco J C Javier B | 1991 | J Sci Food Agric1991，54，： | 1 |
| 20 | Viability PCR, a Culture-Independent Method for Rapid and Selective Quantification of Viable Legionella pneumophila Cells in Environmental Water Samples显示文摘 | Pilar D V Lydie S Delattre J M | 2010 | Applied and Environmental Microbiology2010，6，15： | 1 |
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