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| 1 | Effect of Helicobacter pylori on gastric epithelial cells显示文摘The gastrointestinal epithelium has cells with features that make them a powerful line of defense in innate mucosal immunity. Features that allow gastrointestinal epithelial cells to contribute in innate defense include cell barrier integrity, cell turnover, autophagy, and innate immune responses. Helicobacter pylori(H. pylori) is a spiral shape gram negative bacterium that selectively colonizes the gastric epithelium of more than half of the world's population. The infection invariably becomes persistent due to highly specialized mechanisms that facilitate H. pylori 's avoidance of this initial line of host defense as well as adaptive immune mechanisms. The host response is thus unsuccessful in clearing the infection and as a result becomes established as a persistent infection promoting chronic inflammation. In some individuals the associated inflammation contributes to ulcerogenesis or neoplasia. H. pylori has an array of different strategies to interact intimately with epithelial cells and manipulate their cellular processes and functions. Among the multiple aspects that H. pylori affects in gastric epithelial cells are their distribution of epithelial junctions, DNA damage, apoptosis, proliferation, stimulation of cytokine production, and cell transformation. Some of these processes are initiated as a result of the activation of signaling mechanisms activated on binding of H. pylori to cell surface receptors or via soluble virulence factors that gain access to the epithelium. The multiple responses by the epithelium to the infection contribute to pathogenesis associated with H. pylori. | Shatha Alzahrani Taslima T Lina Jazmin Gonzalez Irina V Pinchuk Ellen J Beswick Victor E Reyes | 2014 | World Journal of Gastroenterology2014，20，36： | 15 |
| 2 | Immune evasion strategies used by Helicobacter pylori显示文摘Helicobacter pylori(H. pylori) is perhaps the most ubiquitous and successful human pathogen, since it colonizes the stomach of more than half of humankind. Infection with this bacterium is commonly acquired during childhood. Once infected, people carry the bacteria for decades or even for life, if not treated. Persistent infection with this pathogen causes gastritis, peptic ulcer disease and is also strongly associated with the development of gastric cancer. Despite induction of innate and adaptive immune responses in the infected individual, the host is unable to clear the bacteria. One widely accepted hallmark of H. pylori is that it successfully and stealthily evades host defense mechanisms. Though the gastric mucosa is well protected against infection, H. pylori is able to reside under the mucus, attach to gastric epithelial cells and cause persistent infection by evading immune responses mediated by host. In this review, we discuss how H. pylori avoids innate and acquired immune response elements, uses gastric epithelial cells as mediators to manipulate host T cell responses and uses virulence factors to avoid adaptive immune responses by T cells to establish a persistent infection. We also discuss in this review how the genetic diversity of this pathogen helps for its survival. | Taslima T Lina Shatha Alzahrani Jazmin Gonzalez Irina V Pinchuk Ellen J Beswick Victor E Reyes | 2014 | World Journal of Gastroenterology2014，20，36： | 7 |
| 3 | The use of poly(styrene-block-isobutyleneblock-styrene)as a microshunt to treat glaucoma显示文摘The InnFocus MicroShuntVR is a minimally invasive glaucoma drainage microtube used to shunt aqueous humor from the anterior chamber of the eye to a flap formed under the conjunctiva and Tenon’s capsule.The safety and clinical performance of this device approaches that of trabeculectomy with mitomycin C,the current‘gold standard’treatment for advanced glaucoma.The invention of a new biomaterial called poly(styrene-block-isobutylene-block-styrene)or‘SIBS’is the enabling factor which led to the success of this product.SIBS is ultrastable with virtually no foreign body reaction in the body,which manifests as clinically insignificant inflammation and capsule formation in the eye.The lack of capsule formation enables unobstructed flow through the 70 mm lumen tube and the achievement of controlled low intraocular pressure,which is important for the management of glaucoma.This article summarizes the integration of SIBS into a glaucoma drainage device and confirms its functionality with clinical success over a 2-year period. | Leonard Pinchuk Isabelle Riss Juan F.Batlle Yasushi P.Kato John B.Martin Esdras Arrieta Paul Palmberg Richard K.Parrish Bruce A.Weber Yongmoon Kwon Jean-Marie Parel | 2016 | Regenerative Biomaterials2016，3，2： | 5 |
| 4 | Ab externo implantation of the MicroShunt, a poly (styrene-block-isobutylene-blockstyrene) surgical device for the treatment of primary open-angle glaucoma: a review显示文摘Trabeculectomy remains the‘gold standard’intraocular pressure(IOP)-lowering procedure for moderate-to-severe glaucoma;however,this approach is associated with the need for substantial post-operative management.Microinvasive glaucoma surgery(MIGS)procedures aim to reduce the need for intra-and post-operative management and provide a less invasive means of lowering IOP.Generally,MIGS procedures are associated with only modest reductions in IOP and are targeted at patients with mild-to-moderate glaucoma,highlighting an unmet need for a less invasive treatment of advanced and refractory glaucoma.The PRESERFLO®MicroShunt(formerly known as InnFocus MicroShunt)is an 8.5 mm-long(outer diameter 350μm;internal lumen diameter 70μm)glaucoma drainage device made from a highly biocompatible,bioinert material called poly(styrene-block-isobutylene-blockstyrene),or SIBS.The lumen size is sufficiently small that at normal aqueous flow hypotony is avoided,but large enough to avoid being blocked by sloughed cells or pigment.The MicroShunt achieves the desired pressure range in the eye by draining aqueous humor from the anterior chamber to a bleb formed under the conjunctiva and Tenon’s capsule.The device is implanted ab externo with intraoperative Mitomycin C via a minimally invasive(relative to incisional surgery)surgical procedure,enabling precise control of placement without the need for gonioscopy,suture tension control,or suture lysis.The implantation procedure can be performed in combination with cataract surgery or as a standalone procedure.The MicroShunt received ConformitéEuropéenne(CE)marking in 2012 and is intended for the reduction of IOP in eyes of patients with primary open-angle glaucoma in which IOP remains uncontrolled while on maximum tolerated medical therapy and/or in which glaucoma progression warrants surgery.Three clinical studies assessing the long-term safety and efficacy of the MicroShunt have been completed;a Phase 3 multicenter,randomized clinical study comparing the MicroShunt to primary trabeculectomy is underway.In preliminary studies,the MicroShunt effectively reduced IOP and use of glaucoma medications up to 3 years after implantation,with an acceptable safety profile.This article summarizes current literature on the unique properties of the MicroShunt,the preliminary efficacy and safety findings,and discusses its potential use as an alternative to trabeculectomy for glaucoma surgery. | Omar Sadruddin Leonard Pinchuk Raymund Angeles Paul Palmberg | 2019 | Eye and Vision2019，6，1： | 2 |
| 5 | Modeling of biological processes using self-cycling fermentation and genetic algorithms显示文摘 | Pinchuk R J Brown W A Hughes S M | 2000 | Biotechnoi Bioeng2000，，67： | 1 |
| 6 | In vitro anti-Helicobacter pylori activity of the probiotic strain Bacillus显示文摘 | Pinchuk IV Bressollier P Verneuil B | 2001 | Antimicrob Agents Chemother2001，45，11： | 1 |
| 7 | Bovine monocytes induce im- munoglobulin production in peripheral blood B lymphocytes显示文摘 | KRUGER E F BOYD B L PINCHUK L M | 2003 | Develop- mental & Comparative Immunology2003，27，10： | 1 |
| 8 | Expression d the progamed death ligand 1, B7-H1, on gastric epithelial cells after Helicobacter pylori exposure promotes development of CIM +CIY25 + Foxp3 + regulatory T cells显示文摘 | Beswick EJ Pinchuk IV Das S | 2007 | Infect Immun2007，75，9： | 1 |
| 9 | Flavonoids induce apoptosis in human leukemia U937 cells through caspase-and caspase-calpain-dependent pathways显示文摘 | Monasterio A Urdaci MC Pinchuk Ⅳ | | 0，，： | 1 |
| 10 | Helicobaeter pylori Ca- gA-dependent macrophage migration inhibitory factor produced by gastric epithelial cells binds to CD74 and stimulates procarcino- genie events 显示文摘 | Beswick E J Pinchuk IV Suarez G | 2006 | J Immunol2006，176，11： | 1 |
| 11 | Medical applications of poly(styrene-block-isobutylene-block-styrene) ( 'SIBS' )显示文摘 | Pinchuk L Wilson G J Barry J J | 2008 | Biomaterial2008，29，： | 1 |
| 12 | Optical bistability in nonlinear composites with coated ellipsoidal nanparticles显示文摘 | Anatoliy Pinchuk | 2003 | J Phys D:Appl Phys2003，36，： | 1 |
| 13 | Evalution of an integrated orbitaltissue expander in an anophthalmic feline model显示文摘 | TSE D T PINCHUK L DAVIS S el al | | 0，，： | 1 |
| 14 | Evaluation of antioxidants: Scope, limitations and relevance of assays显示文摘 | I. Pinchuk H. Shoval Y. Dotan D. Lichtenberg | 2012 | Chemistry and Physics of Lipids2012，，6： | 1 |
| 15 | Seasonal changes in the diet composition and prey selection of walleye pollock ( Theragra chalcogramma ) in the northern Gulf of Alaska 显示文摘 | Adams C F Pinchuk A I Coyle K O | 2007 | Fisheries Research2007，84，3： | 1 |
| 16 | Mesenchymal cells of the intestinal lamina propria 显示文摘 | Powell DW Pinchuk IV Saada JI | 2011 | Annu Rev Physiol2011，73，： | 1 |
| 17 | Implant ruptures after augmentation mammoplasty显示文摘 | Pinchuk V Tymofii O Tkach O | 2013 | Aesthetic Plast Surg2013，37，1： | 1 |
| 18 | Helicobacter pylori CagA-dependent macrophage migration inhibitory factor produced by gastric epithelial cells binds to CD74 and stimulates procarcinogenic events 显示文摘 | Beswick EJ Pinchuk IV Suarez G | 2006 | J Immunol2006，176，11： | 1 |
| 19 | In vitro atrazine exposure affects the phenotypic and functional maturation of dendritic cells 显示文摘 | Pinchuk LM Lee SR Filipov NM | 2007 | Toxicol Appl Pharmacol2007，223，3： | 1 |
| 20 | Functional CD40 ligand expressed by human blood dendritic cells is up-regulated by CD40 ligation显示文摘 | Pinchuk LM Klaus SJ Magaletti DM | 1996 | J Immunol1996，157，： | 1 |
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