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| 1 | The MicroRNA miR-139 Suppresses Metastasis and Progression of Hepatocellular Carcinoma by Down-regulating Rho-Kinase 2显示文摘 | Carmen Chak–Lui Wong Chun–Ming Wong Edmund Kwok–Kwun Tung Sandy Leung–Kuen Au Joyce Man–Fong Lee Ronnie Tung–Ping Poon Kwan Man Irene Oi–Lin Ng | 2011 | Gastroenterology2011，，1： | 1 |
| 2 | Photo-functionalized TiO_(2) nanotubes decorated with multifunctional Ag nanoparticles for enhanced vascular biocompatibility显示文摘Titanium dioxide(TiO2)has a long history of application in blood contact materials,but it often suffers from insufficient anticoagulant properties.Recently,we have revealed the photocatalytic effect of TiO2 also induces anticoagulant properties.However,for long-term vascular implant devices such as vascular stents,besides anticoagulation,also anti-inflammatory,anti-hyperplastic properties,and the ability to support endothelial repair,are desired.To meet these requirements,here,we immobilized silver nanoparticles(AgNPs)on the surface of TiO2 nanotubes(TiO2-NTs)to obtain a composite material with enhanced photo-induced anticoagulant property and improvement of the other requested properties.The photo-functionalized TiO2-NTs showed protein-fouling resistance,causing the anticoagulant property and the ability to suppress cell adhesion.The immobilized AgNPs increased the photocatalytic activity of TiO2-NTs to enhances its photo-induced anticoagulant property.The AgNP density was optimized to endow the TiO2-NTs with anti-inflammatory property,a strong inhibitory effect on smooth muscle cells(SMCs),and low toxicity to endothelial cells(ECs).The in vivo test indicated that the photofunctionalized composite material achieved outstanding biocompatibility in vasculature via the synergy of photo-functionalized TiO2-NTs and the multifunctional AgNPs,and therefore has enormous potential in the field of cardiovascular implant devices.Our research could be a useful reference for further designing of multifunctional TiO2 materials with high vascular biocompatibility. | Jiang Chen Sheng Dai Luying Liu Manfred F.Maitz Yuzhen Liao Jiawei Cui Ansha Zhao Ping Yang Nan Huang Yunbing Wang | 2021 | Bioactive Materials2021，6，1： | 1 |
| 3 | Scientific objectives of the Hot Universe Baryon Surveyor(HUBS) mission显示文摘The Hot Universe Baryon Surveyor(HUBS) is a proposed space-based X-ray telescope for detecting X-ray emissions from the hot gas content in our universe. With its unprecedented spatially-resolved high-resolution spectroscopy and large field of view,the HUBS mission will be uniquely qualified to measure the physical and chemical properties of the hot gas in the interstellar medium, the circumgalactic medium, the intergalactic medium, and the intracluster medium. These measurements will be valuable for two key scientific goals of HUBS, namely to unravel the AGN and stellar feedback physics that governs the formation and evolution of galaxies, and to probe the baryon budget and multi-phase states from galactic to cosmological scales. In addition to these two goals, the HUBS mission will also help us solve some problems in the fields of galaxy clusters, AGNs, difuse X-ray backgrounds, supernova remnants, and compact objects. This paper discusses the perspective of advancing these fields using the HUBS telescope. | Joel Bregman Renyue Cen Yang Chen Wei Cui Taotao Fang Fulai Guo Edmund Hodges-Kluck Rui Huang Luis C.Ho Li Ji Suoqing Ji Xi Kang Xiaoyu Lai Hui Li Jiangtao Li Miao Li Xiangdong Li Yuan Li Zhaosheng Li Guiyun Liang Helei Liu Wenhao Liu Fangjun Lu Junjie Mao Gabriele Ponti Zhijie Qu Chenxi Shan Lijing Shao Fangzheng Shi Xinwen Shu Lei Sun Mouyuan Sun Hao Tong Junfeng Wang Junxian Wang Q.Daniel Wang Song Wang Tinggui Wang Weiyang Wang Zhongxiang Wang Dandan Xu Haiguang Xu Heng Xu Renxin Xu Xiaojie Xu Yongquan Xue Hang Yang Feng Yuan Shuinai Zhang Yuning Zhang Zhongli Zhang Yuanyuan Zhao Enping Zhou Ping Zhou | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，9： | 1 |
| 4 | 油气藏井间监测新技术及其应用显示文摘目前,井间监测技术正朝着将地层测量从近井区域推向储层深处这一方向发展。油气藏管理人员可以利用根据测量结果获得的层析成像来监测地层深处流体的流动情况。 | Zaki A.Al-Ali Muhammad H.Al-Buali Saleh AIRuwaili Shouxiang Mark Ma Alherto F.Marsala David Alumbaugh Luis DePavia Cyrille Levesque Ajay Nalonnil Ping Zhang Colin Hulme Michael Wilt | 2010 | 国外测井技术2010，，3： | 1 |
| 5 | Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression显示文摘 | Patrick Kwan Wai Sang Poon Ho-Keung Ng David E. Kang Virginia Wong Ping Wing Ng Colin H.T. Lui Ngai Chuen Sin Ka S. Wong Larry Baum | 2008 | Pharmacogenetics and Genomics2008，，11： | 1 |
| 6 | Completely Generalized Strongly Set-valued Nonlinear Quasi-complementarity Problems显示文摘In this paper,we study a class of completely generalized strongly set-valued nonlinearquasi-complementarity problems and discuss the existence of solutions for this kind of quasi-complementariy problems without compactness and the convergence of iterative sequencesgenerated by the algorithms. | Dingpin Wu Zhi Ping Lui | 1998 | 宜宾学院学报1998，，2： | 0 |
| 7 | Very large hidden genetic diversity in one single tumor:evidence fortumors-in-tumor显示文摘Despite the concern of within-tumor genetic diversity,this diversity is in fact limited by the kinship among cells in the tumor.Indeed,genomic studies have amply supported the’Nowell dogma’whereby cells of the same tumor descend from a single progenitor cell.In parallel,genomic data also suggest that the diversity could be>10-fold larger if tumor cells are of multiple origins.We develop an evolutionary hypothesis that a single tumor may often harbor multiple cell clones of independent origins,but only one would be large enough to be detected.To test the hypothesis,we search for independent tumors within a larger one(or tumors-in-tumor).Very high density sampling was done on two cases of colon tumors.Case 1 indeed has 13 independent clones of disparate sizes,many having heavy mutation burdens and potentially highly tumorigenic.In Case 2,despite a very intensive search,only two small independent clones could be found.The two cases show very similar movements and metastasis of the dominant clone.Cells initially move actively in the expanding tumor but become nearly immobile in late stages.In conclusion,tumors-in-tumor are plausible but could be very demanding to find.Despite their small sizes,they can enhance the within-tumor diversity by orders of magnitude.Such increases may contribute to the missing genetic diversity associated with the resistance to cancer therapy. | Bingjie Chen Xianrui Wu Yongsen Ruan Yulin Zhang Qichun Cai Luis Zapata Chung-I Wu Ping Lan Haijun Wen | 2022 | National Science Review2022，9，12： | 0 |
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