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| 1 | clusterProfiler 4.0:A universal enrichment tool for interpreting omics data显示文摘Functional enrichment analysis is pivotal for interpreting highthroughput omics data in life science.It is crucial for this type of tool to use the latest annotation databases for as many organisms as possible.To meet these requirements,we present here an updated version of our popular Bioconductor package,clusterProfiler 4.0.This package has been enhanced considerably compared with its original version published 9 years ago.The new version provides a universal interface for functional enrichment analysis in thousands of organisms based on internally supported ontologies and pathways as well as annotation data provided by users or derived from online databases.It also extends the dplyr and ggplot2 packages to offer tidy interfaces for data operation and visualization.Other new features include gene set enrichment analysis and comparison of enrichment results from multiple gene lists.We anticipate that clusterProfiler 4.0 will be applied to a wide range of scenarios across diverse organisms. | Tianzhi Wu Erqiang Hu Shuangbin Xu Meijun Chen Pingfan Guo Zehan Dai Tingze Feng Lang Zhou Wenli Tang Li Zhan Xiaocong Fu Shanshan Liu Xiaochen Bo Guangchuang Yu | 2021 | The Innovation2021，2，3： | 40 |
| 2 | Detection of micrometastasis in peripheral blood by multi-sampling in patients with colorectal cancer显示文摘AIM: To evaluate the reverse transcriptase-PCR assay and multiple sampling for detection of cytokeratin-positive cells in peripheral blood of colorectal carcinoma patients and to investigate the clinical significance of micrometastasis in peripheral blood.METHODS: The expression of CK20 mRNA by RT-PCR was investigated in bone marrow, portal vein and peripheral blood in 58 colorectal cancer patients and 12 controls without known cancer. The peripheral blood was sampled twice at intervals of 3 d before operation. All the patients were followed up for one year.RESULTS: There was no positive expression of CK20mRNA in 12 volunteers. The positive expression of CK20mRNA was 77.6% (45/58) in bone marrow, and that in portal vein was 74.1% (43/58) of colorectal carcinoma patients.The positive expression of CK20mRNA cells in peripheral blood rose from 44.8% (26/58) to 69.0% (40/58) (P<0.01).The total positivity of CK20mRNA expression in peripheral blood was similar to the positivity of CK20mRNA in bone marrow and portal vein. The positive rates became higher in later clinical stages than in early stages. The CK20mRNA positive patients had a higher relapse rate within one year than the CK20mRNA negative patients.CONCLUSION: Multiple blood sampling can increase the detection of tumor cells in peripheral blood by RT-PCR for CK20mRNA in colorectal carcinoma patients and it is as sensitive and specific as that of bone marrow and portal vein. This technique may be reliable and convenient to diagnose micrometastasis of colorectal carcinoma and has an important significance in determining the prognosis of cancer patients. | Xi-WeiZhang Hong-YuYang PingFan LiYang Guo-YuChen | 2005 | World Journal of Gastroenterology2005，11，3： | 25 |
| 3 | Hypothesis review:The direct interaction of food nanoparticles with the lymphatic system显示文摘Besides digestion and assimilation,there are other modes of direct interaction between food and human body.As it is known,the mucosal layer of the digestive tract interfaces with food after the digestion process.It has been demonstrated to uptake the micro-and nanoparticles via mucosa-associated lymphatic tissues(MALT).On the other hand,food is a typical polydisperse system and contains micro-and nanoparticles with different sizes and properties.Accordingly,it is hypothesized that food nanoparticles can directly interact with MALT and more specifically with the support of the preliminary experimental data from our research,that antioxidant nanoparticles can interact with the lymphatic vessels.This kind of interaction would be of great physiological importance.The confirmation of the hypothesis will establish a significant and novel approach to understand food system and provide answers to currently incomprehensible phenomena such as the biological functions of phytochemicals with low bioavailability.©2012 Production and hosting by Elsevier B.V.on behalf of Beijing Academy of Food Sciences. | Wei Lu Jingke Guo Jianwu Zhou Lijing Ke Shutao Liu Guanzhen Gao Huiqin Wang Wei Ding Pingfan Rao | 2012 | Food Science and Human Wellness2012，1，1： | 5 |
| 4 | How China Could Contribute to a Benign Global Rebalancing?显示文摘我们中国能贡献的学习表演一有序全球用政策的一个包裹重新平衡刺激它的国内消费。这些政策包括对 RMB,由在教育上增加开销的财政刺激,护理,社会安全网络和贫穷的进步欣赏减小,减少不平等并且加强工资收入的收入政策,和改进金融效率并且减轻金融限制的金融系统的改革。由实现如此的政策,中国的外部剩余能被缩小,它的国内不平衡改善了。过分地高的积蓄率能被降低,家庭消费的份额增加了,尽管 GDP 生长将稍微节制。 | Pingfan Hong Rob Vos Keping Yao | 2008 | China & World Economy2008，16，5： | 4 |
| 5 | China's Economic Prospects and Sino-US Economic Relations显示文摘A better comprehension of the mixed sentiment in the rest of world towards the rapid rise of the Chinese economy will depend on the understanding of some key features of the Chinese economy, such as those associated with its size, structure and institution. To further sustain its high growth, China is facing more challenges than it has encountered in the past 2 decades, including a gamut of material constraints. Although polices and technological progress might alleviate many of these constraints, the ultimate solution will still lie in continued institutional reform. China’s recent move towards a more flexible exchange rate regime is in line with its broad reform and in accordance with the progress of its development. However, such a move will have limited immediate effects on the prodigious US trade deficit, which itself is a problem rooted in the flawed international reserve system, far beyond a Sino–US trade issue. | Pingfan Hong | 2006 | China & World Economy2006，14，2： | 4 |
| 6 | An experiment study of lee vortex with large topography forcing显示文摘This paper, relates the lee vortex which is trig- gered when the rotating and stratified flow passes over the large obstacle by using towing tank and based on the simi- larity. The results show that Froude number Fr is the most important parameter, and, in the rotating case, the lee vortex is easily triggered, because the rotating may, on one hand, lead to downward flow, on the other hand, induce lee vortex through generating geostrophic vorticity. Even in the non-rotating case, the lee vortex can be still formed, as long as both Froude number Fr and stratification parameter N are appropriate. For the formation mechanism of the lee vortex, there are obvious differences in the rotating case compared with the non-rotating case. In the non-rotating case, the tilting term of the perturbation vorticity is a domi- nant factor of inducing the lee vortex. However, in the rotat- ing case, effect and the convergence of perturbation vorticity are dominant factors. | GAOShouting PINGFan | 2005 | Chinese Science Bulletin2005，50，3： | 3 |
| 7 | Improved peroxidase-mimic property: Sustainable, high- efficiency interfacial catalysis with H2O2 on the surface of vesicles of hexavanadate-organic hybrid surfactants显示文摘 | Kun Chen Aruuhan Bayaguud Hui Li Yang Chu Haochen Zhang Hongli Jia Baofang Zhang Zicheng Xiao Pingfan Wu Tianbo Liu Yongge wei | 2018 | Nano Research2018，11，3： | 2 |
| 8 | Dye-sensitized solar cells based on anatase TiO 2 /multi-walled carbon nanotubes composite nanofibers photoanode显示文摘 | Pingfan Du Lixin Song Jie Xiong Ni Li Lijun Wang Zhenqiang Xi Naiyan Wang Linhui Gao Hongliang Zhu | 2013 | Electrochimica Acta2013，，： | 1 |
| 9 | Information measure for performance of image fusion 显示文摘 | Qu Guihong ZHANG Dali VAN Pingfan | 2002 | Elec- tronics Letters2002，38，7： | 1 |
| 10 | Information Measure for Performance of Image Fusion显示文摘 | QU GUIHONG ZHANG DALI YAN PINGFAN | 2002 | Electronics Letters2002，38，7： | 1 |
| 11 | Information Measure forPerformance of Image Fusion显示文摘 | Qu Guihong Zhang Dali Yan Pingfan | 2002 | Electronics Letters2002，38，7： | 1 |
| 12 | Information measure for performance of image fusion 显示文摘 | Qu Guihong Zhang Dali Yan Pingfan | 2002 | Electronics Letters2002，38，7： | 1 |
| 13 | Information measure for performance of image fusion 显示文摘 | Qu Guihong Zhang Dali Yan Pingfan | 2002 | Electronics Letters2002，38，7： | 1 |
| 14 | Information Measure for Performance of Image Fusion 显示文摘 | QU Quihong ZHANG Dali YAN Pingfan | 2002 | IEEE E-lectronics Letters2002，7，38： | 1 |
| 15 | Information Measure for Performance of Image Fusion显示文摘 | Qu Guihong Zhang Dali Yan Pingfan | 2002 | Electronics Letters2002，38，7： | 1 |
| 16 | Information measure for performance of image fusion显示文摘 | Qu Guihong Zhang Dali Yan Pingfan | 2002 | Electronics Letters2002，37，7： | 1 |
| 17 | Information measure for performance of image fusion显示文摘 | QU Guihong ZHANG Dali YANG Pingfan | 2002 | Electronics Letters2002，38，7： | 1 |
| 18 | Information Measure for Performance of Image Fusion显示文摘 | Guihong Q Dali Z Pingfan Y | 2002 | Electronics Letters2002，38，7： | 1 |
| 19 | A Genetic Algorithm of Solving Jop-Shop Scheduling Problem显示文摘 | Yan Pingfan | 1995 | Chinese Journal of Electronics1995，4，1： | 1 |
| 20 | lnfbrmation measure for per- formance of image fusion 显示文摘 | QU Guihong ZHANG Dali YAN Pingfan | 2002 | Electronics Letters2002，38，7： | 1 |
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