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| 1 | Brain stem cells as the cell of origin in glioma显示文摘Glioma incidence rates in the United States are near 20000 new cases per year, with a median survival time of 14.6 mo for high-grade gliomas due to limited therapeutic options. The origins of these tumors and their many subtypes remain a matter of investigation. Evidence from mouse models of glioma and human clinical data have provided clues about the cell types and initiating oncogenic mutations that drive gliomagenesis, a topic we review here. There has been mixed evidence as to whether or not the cells of origin are neural stem cells, progenitor cells or differentiated progeny. Many of the existing murine models target cell populations defined by lineage-specific promoters or employ lineagetracing methods to track the potential cells of origin. Our ability to target specific cell populations will likely increase concurrently with the knowledge gleaned from an understanding of neurogenesis in the adult brain. The cell of origin is one variable in tumorigenesis, as oncogenes or tumor suppressor genes may differentially transform the neuroglial cell types. Knowledge of key driver mutations and susceptible cell types will allow us to understand cancer biology from a developmental standpoint and enable early interventional strategies and biomarker discovery. | Aram S Modrek N Sumru Bayin Dimitris G Placantonakis | 2014 | World Journal of Stem Cells2014，6，1： | 12 |
| 2 | Glioblastoma stem cells:Molecular characteristics and therapeutic implications显示文摘Glioblastoma Multiforme(GBM)is a grade IV astrocytoma,with a median survival of 14.6 mo.Within GBM,stem-like cells,namely glioblastoma stem cells(GSCs),have the ability to self-renew,differentiate into distinct lineages within the tumor and initiate tumor xenografts in immunocompromised animal models.More importantly,GSCs utilize cell-autonomous and tumor microenvironment-mediated mechanisms to overcome current therapeutic approaches.They are,therefore,very important therapeutic targets.Although the functional criteria defining GSCs are well defined,their molecular characteristics,the mechanisms whereby they establish the cellular hierarchy within tumors,and their contribution to tumor heterogeneity are not well understood.This review is aimed at summarizing current findings about GSCs and their therapeutic importance from a molecular and cellular point of view.A better characterization of GSCs is crucial for designing effective GSCtargeted therapies. | Nermin Sumru Bayin Aram Sandaldjian Modrek Dimitris George Placantonakis | 2014 | World Journal of Stem Cells2014，6，2： | 3 |
| 3 | Intrathecal fluorescein in endoscopic skull base surgery 显示文摘 | Tabaee A Placantonakis DG Schwartz TH | 2007 | Otolaryngol Head Neck Surg2007，137，2： | 1 |
| 4 | Why do Purkinje cells die so easily after global brain ischemia? Aldolase C, EAAT4, and the cerebellar contribution to posthypoxic myoclonus 显示文摘 | Welsh JP Yuen G Placantonakis DG | 2002 | Adv Neurol2002，89，： | 1 |
| 5 | Safety of low-dose intrathecal fluoreseein in endoscopic cranial base sur- gery显示文摘 | Placantonakis DG Tabaee A Anand VK | 2007 | Neurosurgery2007，61，3： | 1 |
| 6 | The serotonin hypothesis of myoclonus from the perspective of neuronal rhythmicity显示文摘 | Welsh JP Placantonakis DG Warsetsky SI | | 0，，： | 1 |
| 7 | Why do Purkinje cells die so easily after global brain ischemia?Aldolase C,EAAT4,and the cerebellar contribution to posthypoxic myoclonus显示文摘 | Welsh JP Yuen G Placantonakis DG | 2002 | Adv Neurol2002，89，： | 1 |
| 8 | BAC Transgenesis in human embryonic stem cells as a novel tool to define the human neural lineage 显示文摘 | Placantonakis Dimitris G Tomishima | 2009 | Stem Cells2009，27，3： | 1 |
| 9 | Transsphenoidal resection of sellar tumors using high-field intraoperative magnetic reso- nance imaging显示文摘 | SZERLIP N J ZHANG Y C PLACANTONAKIS D G | 2011 | Skull Base2011，21，： | 1 |
| 10 | Posterior stabilization strategies following resection of cervicothoracic junction tumors:review of 90 consecutive cases显示文摘 | Placantonakis DG Laufer I Wang JC | 2008 | Neurosurg Spine2008，9，2： | 1 |
| 11 | Localization in epilepsy 显示文摘 | Placantonakis D G Schwartz T H | 2009 | Neurol Clin2009，27，4： | 1 |
| 12 | Transsphenoidal resection of sellar tumors using high-field intraoperative magnetic resonance imaging显示文摘 | Szerlip NJ Zhang YC Placantonakis DG | | 0，，04： | 1 |
| 13 | Intrathecal fluorescein in endoscopic skull base surgery显示文摘 | Abtin Tabaee Dimitris G. Placantonakis Theodore H. Schwartz Vijay K. Anand | 2007 | Otolaryngology - Head and Neck Surgery2007，，2： | 1 |
| 14 | The serotoninhypothesis of myoclonus from the perspective of neuronal rhythmicity显示文摘 | Welsh JP Placantonakis DG Warsetsky SI | 2002 | Adv Neurol2002，89，： | 1 |
| 15 | Intrathecal fluorescein in endoscopic skull base surgery 显示文摘 | Tabaee A Placantonakis DG Schwartz TH | 2007 | Otolaryngol Head Neck Surg2007，137，2： | 1 |
| 16 | Bilateral intracranial electrodes for lateralizing intractable epilepsy: efficacy, risk, and outcome 显示文摘 | Placantonakis DG Shariff S Lafaille F et ol | 2010 | Neurosurgery2010，66，2： | 1 |
| 17 | Transsphe- noidal resection of sellar tumors using high-field intraoperative magnetic resonance imaging 显示文摘 | Szerlip NJ Zhang YC Placantonakis DG | 2011 | Skull Base2011，21，4： | 1 |
| 18 | Why do Purkinje cells die so easily after global brain ischemia? Aldolase C,EAAT4,and the cerebellar contribution to posthypoxic myoclonus显示文摘 | Welsh JP Yuen G Placantonakis DG | | 0，，： | 1 |
| 19 | The serotonin hypothesis of myoclonus from the perspective of neuronal rhythmicity显示文摘 | Welsh JP Placantonakis DG Warsetsky SI | 2002 | Adv Neurol2002，89，： | 1 |
| 20 | The serotonin hypothesis of myoclonus from the perspective of neuronal rhythmicity显示文摘 | Welsh JP Placantonakis DG Warsetsky SI | 2002 | Adv Neurol2002，89，： | 1 |
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