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| 1 | Safety of immediate endoscopic sphincterotomy in acutesuppurative cholangitis caused by choledocholithiasis显示文摘AIM: To examine the safety of immediate endoscopic sphincterotomy(EST) in patients with acute suppurative cholangitis(ASC) caused by choledocholithiasis, as compared with elective EST.METHODS: Patients with ASC due to choledocholithiasis were allocated to two groups: Those who underwent EST immediately and those who underwent EBD followed by EST 1 wk later because they were under anticoagulant therapy, had a coagulopathy(international normalized ratio > 1.3, partial thromboplastin time greater than twice that of control), or had a platelet count < 50000 × 103/μL. One of four trainees [200-400 cases of endoscopic retrograde cholangiopancreatography(ERCP)] supervised by a specialist(> 10000 cases of ERCP) performed the procedures. The success and complication rates associated with EST in each group were examined.RESULTS: Of the 87 patients with ASC, 59 were in the immediate EST group and 28 in the elective EST group. EST was successful in all patients in both groups. There were no complications associated with EST in either group of patients, although white blood cell count, C-reactiveprotein, total bilirubin, and serum concentrations of liver enzymes just before EST were significantly higher in the immediate EST group than in the elective EST group.CONCLUSION: Immediate EST can be as safe as elective EST for patients with ASC associated with choledocholithiasis provided they are not under anticoagulant therapy, or do not have a coagulopathy or a platelet count < 50000 × 103/μL. Moreover, the procedure was safely performed by a trainee under the supervision of an experienced specialist. | Tomoyasu Ito Jin Kan Sai Hironao Okubo Hiroaki Saito Shigeto Ishii Ryo Kanazawa Ko Tomishima SumioWatanabe Shuichiro Shiina | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，3： | 10 |
| 2 | FK463, a novel water-soluble echinocandin lipopeptide: synthesis and antifungal activity 显示文摘 | Tomishima M Ohki H Yamada A | 1999 | J Antibiot ( Tokyo)1999，52，7： | 1 |
| 3 | Virus-assisted mapping of neural inputs to a feeding center in the hypothalamus显示文摘 | DEFALCO J TOMISHIMA M LIU H | 2001 | Science2001，291，5513： | 1 |
| 4 | FK463, a novel water- soluble echinocandin lipopeptide: synthesis and antifungal activity 显示文摘 | Tomishima M Ohki H Yanada A | 1999 | JAntibiot(Tokyo)1999，52，7： | 1 |
| 5 | Therapeutic cloning in individual parkinsonian mice显示文摘 | Tabar V Tomishima M Panagiotakos G | 2008 | Nat Med2008，14，4： | 1 |
| 6 | FK463,a novel water-soluble echinocandin lipopeptide:synthesis and antifungal activity显示文摘 | TOMISHIMA M OHKI H YAMADA A | 1999 | J Antibiot(Tokyo)1999，52，7： | 1 |
| 7 | BAC Transgenesis in human embryonic stem cells as a novel tool to define the human neural lineage 显示文摘 | Placantonakis Dimitris G Tomishima | 2009 | Stem Cells2009，27，3： | 1 |
| 8 | A conserved alpha-herpesvirus protein necessary for axonal localization of viral membrane proteins显示文摘 | Tomishima M J Enquist L W | 2001 | J Cell Biol2001，154，4： | 1 |
| 9 | Virus-assisted mapping of neural inputs to a feeding center in the hypothalamus 显示文摘 | DeFalco J Tomishima MJ Liu H | 2001 | Science2001，291，5513： | 1 |
| 10 | Derivation of neural crest ceUs from human pluripotent stem cells 显示文摘 | Lee G Chambers SM Tomishima MJ | 2010 | Nat Protoc2010，5，： | 1 |
| 11 | FK463,a novel water-soluble Echinocandon lipopeptide:synthesis and antifungal activity显示文摘 | Ohki H Yamada A | 1999 | J Antibiot1999，52，7： | 1 |
| 12 | Derivation of neural crest cells from human pluripotent stem cells显示文摘 | LEE G CHAMBERS S M TOMISHIMA M J | 2010 | Nat Protoc2010，5，4： | 1 |
| 13 | Monte Carlo solutions of Sehrodinger's equation for H2^+ ion in strong magnetic fields( Ⅱ ) 显示文摘 | OZAKI J TOMISHIMA Y | 1983 | J Phys Soc Jpn1983，52，： | 1 |
| 14 | Therapeutic cloning in individual parkinsonian mice显示文摘 | Tabar V Tomishima M Panagiotakos G | 2008 | Nat Med2008，14，4： | 1 |
| 15 | Derivation of neural crest cells from human pluripotent stem cells 显示文摘 | Lee G Chambers SM Tomishima M J | 2010 | Nat Protoc2010，5，4： | 1 |
| 16 | Efficient Derivation of Functional Floor Plate Tissue from Human Embryonic Stem Cells显示文摘 | Christopher A. Fasano Stuart M. Chambers Gabsang Lee Mark J. Tomishima Lorenz Studer | 2010 | Cell Stem Cell2010，，4： | 1 |
| 17 | Derivation of neural crest cells from human pluripotent stem cells显示文摘 | Lee G Chambers SM Tomishima MJ | | 0，，04： | 1 |
| 18 | Therapeutic cloning in individual parkinsonian mice显示文摘 | Tabar V Tomishima M Panagiotakos G | 2008 | Nat Med2008，14，4： | 1 |
| 19 | Derivation of neural crest cells from human pluripotent stem cells 显示文摘 | Lee G Chambers SM Tomishima MJ | 2010 | Nat Protoc2010，5，4： | 1 |
| 20 | Therapeutic cloning in individual parkinsonian mice 显示文摘 | TABAR V TOMISHIMA M PANAGIOTAKOS G | 2008 | Nat Med2008，14，4： | 1 |
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